Chinese Journal of Lasers, Volume. 51, Issue 9, 0907017(2024)

Identification and Risk Assessment of Atherosclerotic Plaques Based on IVOCT

Zejun Han1, Xingkang Lin1, Yaoyang Qiu1, Xiao Zhang1, Lei Gao2、**, and Qin Li1、*
Author Affiliations
  • 1School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China
  • 2The Sixth Medical Center of PLA General Hospital, Beijing 100048, China
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    Figures & Tables(11)
    Automatic identification and risk assessment process of vulnerable plaque. (a) Plaque identification; (b) risk assessment; (c) model testing
    Vulnerable plaque detection network. (a) Feature extraction module; (b) region extraction module; (c) secondary detection module; (d) A-Scan classification module
    Network structure of DeepLabV3+
    Calculation process of fiber cap thickness of vulnerable plaque. (a) Crop result after removing catheter noise by combining vulnerable plaque location information; (b) alignment result of vascular lumen (upper surface); (c) result of noise removal by 5×5 Gaussian filter; (d) calculating segmentation brightness threshold and delineating pixel points exceeding brightness threshold as fiber cap region with fiber cap boundary shown by white line
    Network structure for predicting superficial plaque microcalcification and macrophage infiltration
    Random cyclic shift. (a) Implementation process when area marked by solid line is cropped and spliced to left; (b) two cyclic shift instances, with initial image on left and result of cyclic shift on right
    Positioning and risk assessment results (green mark is actual border, blue mark is Baseline prediction result, and red mark is final prediction result). (a) Polar map positioning; (b) cartesian map positioning; (c) DeepLabV3+ segmentation result; (d) angle of lesion accumulation; (e) confusion matrix of macrophage infiltration; (f) confusion matrix of superficial microcalcification
    • Table 1. High-risk factors and IVOCT image characteristics of vulnerable plaques

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      Table 1. High-risk factors and IVOCT image characteristics of vulnerable plaques

      Risk factor of plaque ruptureHigh risk factorImage characteristic
      Plaque external stressStenosis vascularLumen stenosis
      Plaque mechanical strengthThin fiber capCap thickness ≤65 μm
      Large necrotic coreLesion accumulation angle ≥90°
      Superficial microcalcificationSuperficial calcified nodules and bright spots
      Inflammatory response(macrophage infiltration)Alternating light and dark stripes
    • Table 2. Network performance comparison after introducing each improvement

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      Table 2. Network performance comparison after introducing each improvement

      NetworkmAPmAP50RecallDiceFrame rate /(frame/s)
      Baseline0.4620.7170.8610.89052.0
      Baseline + cyclic shift0.4820.7160.8950.89551.9
      Baseline+(XW)encoding0.4650.7280.8530.88256.7
      Baseline + split branch0.4700.7200.8840.89338.5

      Baseline + cyclic shift +

      XW)encoding

      0.4950.7330.8910.90156.7

      Baseline+cyclic shift+

      XW)encoding+split branch

      0.5030.7440.9120.90541.2
    • Table 3. Performance comparison with existing methods

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      Table 3. Performance comparison with existing methods

      NetworkRecallDice
      WSD0.8840.830
      SRCNN0.9000.887
      Our method0.9120.905
    • Table 4. Subdataset sample distribution for assessing superficial microcalcification and macrophage infiltration

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      Table 4. Subdataset sample distribution for assessing superficial microcalcification and macrophage infiltration

      SampleNumberLabel
      Training setTest setTotal
      Only superficial microcalcification sample8822110[0,1]
      Only macrophage infiltration sample671784[1,0]
      Double positive sample25732[1,1]
      Negative sample11228140[0,0]
      Total sample29274366
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    Zejun Han, Xingkang Lin, Yaoyang Qiu, Xiao Zhang, Lei Gao, Qin Li. Identification and Risk Assessment of Atherosclerotic Plaques Based on IVOCT[J]. Chinese Journal of Lasers, 2024, 51(9): 0907017

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    Paper Information

    Category: biomedical photonics and laser medicine

    Received: Nov. 29, 2023

    Accepted: Jan. 15, 2024

    Published Online: Apr. 26, 2024

    The Author Email: Gao Lei (nkgaolei2010@126.com), Li Qin (liqin@bit.edu.cn)

    DOI:10.3788/CJL231452

    CSTR:32183.14.CJL231452

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