Chinese Journal of Lasers, Volume. 49, Issue 5, 0507102(2022)
Recent Progress in Near-Infrared-Ⅱ Fluorescence Imaging Probes for Fluorescence Surgical Navigation
Figures & Tables(10)
![Chemical structural formula and spectral characteristics of ICG: (a) chemical structural formula of ICG; (b) excitation and NIR-Ⅰ emission spectra of ICG[36]; (c) NIR-Ⅱ emission spectrum of ICG [42]. NIR-Ⅰ and NIR-Ⅱ in vivo imaging of ICG[42]: (d) mouse brain vascular imaging; (e) mouse leg vascular imaging. (f)(h) in vivo imaging of IR-12N3 as a navigation probe[43]: (f) mouse leg lymph nodes imaging; (g) mouse lumbar lymph node imaging; (h) tumor imaging](/Images/icon/loading.gif){kind=icon}
Fig. 3. Chemical structural formula and spectral characteristics of ICG: (a) chemical structural formula of ICG; (b) excitation and NIR-Ⅰ emission spectra of ICG[36]; (c) NIR-Ⅱ emission spectrum of ICG [42]. NIR-Ⅰ and NIR-Ⅱ in vivo imaging of ICG[42]: (d) mouse brain vascular imaging; (e) mouse leg vascular imaging. (f)(h) in vivo imaging of IR-12N3 as a navigation probe[43]: (f) mouse leg lymph nodes imaging; (g) mouse lumbar lymph node imaging; (h) tumor imaging
Fig. 4. NIR-Ⅱ fluorescence surgical navigation of ICG: (a) tumor resection guided by ICG NIR-Ⅱ fluorescence surgical navigation in mouse breast cancer model[50]; in human trials, (b) signal-to-noise ratio of ICG NIR-Ⅱ imaging is higher than that of NIR-Ⅰ imaging, (c) liver cancer resection under ICG NIR-Ⅱ fluorescence surgical navigation[33]. NIR-Ⅱ cyanine dyes with fluorescence surgical navigation potential for NIR-Ⅱ imaging: (d) comparison of imaging effects of FD-1080 under excitation of different wavelengths[51]; (e) NIR-Ⅱ imaging of cyanine dye Flav derivative[52]
Fig. 5. D-A type organic small molecule probe with the potential of fluorescence surgical navigation. (a)(b) D-π-A-π-D type organic small molecule probe and its fluorescence emission spectrum[53]; (c) NIR-Ⅱ fluorescence imaging of small molecule probe CH1055 in brain glioma model[54]; (d) NIR-Ⅱ fluorescence in vivo imaging of organic small molecule probe FM1210 in mouse[56]
Fig. 6. Polymer nanoprobes for NIR-Ⅱ fluorescence imaging. (a) Structures of NIR-Ⅱ polymers P1, P2, and P3[62]; (b) fluorescence emission spectra of nanoprobes P1-Pdots, P2-Pdots, and P3-Pdots assembled with polymers P1, P2, and P3[62]; (c) NIR-Ⅱ fluorescence blood vessels imaging of P1-Pdots[62]; (d) NIR-Ⅱ fluorescence tumor imaging of LNIR-Ⅱ nanoprobe L1057[63]
Fig. 7. Application of AIE fluorescent nanoprobe. NIR-Ⅱ fluorescence imaging of AIE fluorescent nanoprobe SA-TTB-PEG1000 for mouse (a) and New Zealand rabbit (b) [70]; AIE nanoprobe OTPA-BBT for NIR-Ⅱ transcranial blood vessel fluorescence imaging in non-human primates (c) and NIR-Ⅱb gastrointestinal tract fluorescence imaging (d) [72]
Fig. 9. Rare earth nanoprobes for NIR-Ⅱ imaging. (a)(b) DCNPs-L1-FSHβ/ DCNPs-L2-FSHβ for NIR-Ⅱ imaging in ovarian cancer metastasis model[86]; (c) DCNPs-L1-FSHβ/ DCNPs-L2-FSHβfor fluorescence surgical navigation effect display[86]; (d) NPs@Lips for intestinal NIR-Ⅱb imaging[88]；(e) NPs@Lips for intraoperative multispectral imaging of intestinal vessels[88]
Table 1. Fluorescence surgical navigation system[27]
View tableTable 1. Fluorescence surgical navigation system[27]
Imaging system Manufacturer Main application Excitation Field of view Resolution Working distance /mm Color video Clinical status SPY Novodaq Technologies，Mississauga，Canada Intraoperative fluorescence imaging 820 nm laser 190 mm×127 mm Not specified 300 No Food and Drug Administration (FDA) approved Artemis O2view，Marken, the Netherlands Stereoscopic fluorescence imaging 4001000 nm laser 22.5 mm×22.5 mm at 50 mm distance 659 pixel×494 pixel ≥50 Yes FDA approved Fluobeam Fluoptics，Grenoble，France Handheld fluorescence imaging 690 or 780 nm laser 128 mm×94 mm 640 pixel×480 pixel 150 No Clinical trial FLARE Frangioni Laboratory，Boston，USA Intraoperative fluorescence imaging 670 or 760 nm LED 150 mm×113 mm 1280 pixel×1024 × 450 Yes Clinical trial GXMI Navigator Institute of Automation，Beijing，China Intraoperative fluorescence imaging 760 nm LED 250 mm×250 mm 2456 pixel×2048 pixel >300 Yes Clinical trial
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Zuwu Wei, Sen Yang, Ming Wu, Xiaolong Liu. Recent Progress in Near-Infrared-Ⅱ Fluorescence Imaging Probes for Fluorescence Surgical Navigation[J]. Chinese Journal of Lasers, 2022, 49(5): 0507102
Paper Information
Received: Dec. 1, 2021
Accepted: Jan. 14, 2022
Published Online: Mar. 9, 2022
The Author Email: Liu Xiaolong (xiaoloong.liu@gmail.com)
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