Journal of Inorganic Materials, Volume. 40, Issue 2, 145(2025)

Research Progress of Optical Bioimaging Technology Assisted by Upconversion Fluorescence Probes in Tumor Imaging

Tuxun HAIREGU1, Le GUO2, Jiayi DING2, Jiaqi ZHOU1, Xueliang ZHANG1, and Alifu NUERNISHA1、*
Author Affiliations
  • 11. School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi 830011, China
  • 22. School of Public Health, Xinjiang Medical University, Urumqi 830011, China
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    Figures & Tables(16)
    Upconversion nanoparticles (UCNPs) assisted multimodal imaging
    Composition, upconversion luminescence (UCL) emissions and fluorescent energy-level diagrams of the UCNPs[31-32]
    Preparation methods of UCNPs
    Modification methods of UCNPs
    Images of PEI/NaYF4 nanoparticles for human ovarian carcinoma cells and human colon adenocarcinoma cells[44]
    STExD (stimulated-emission induced excitation depletion) imaging of immunolabelled subcellular filaments[50]
    UCNPs containing lanthanide elements Yb (a) and Lu (b) used as CT imaging contrast agents[56-57]
    Application of UCNPs in UCL/MRI dual-modality imaging[66]
    Preparation and UCL/MRI application of NaYF4: Yb/Er@NaGdF4@metal-organic frameworks (MOFs) @doxorubicin (DOX)[67]
    Preparation of Lip-FNPs-Gd nanocomposite and its application in T1-T2 MRI/UCL dual-modality imaging[68]
    MOF@UCNP formed by combination of dual photosensitizers chlorin e6 (Ce6) and rose Bengal (RB) used for MRI/UCL dual-mode imaging[69]
    Application of MUCNPs@BPNs-Ce6 in T1- and T2-weighted MRI[72]
    Schematic illustration of therapy strategy of NaYF4: Yb, Er@mSiO2@Ce6&α-ketoglutaric acid&GOx@mMnO2@HA (UCAGMH) nanoplatforms for breast tumors[73]
    FYH-PDA-DOX nanoparticles used for photothermal therapy (PTT)-chemo-immunotherapy with multimodality UCL/CT/MRI guidance[77]
    Preparation (up row) and application of MRI, UCL and PET imaging (low row) in mice carrying three gene breast cancer of RBC-UCNPs nanoparticles[79]
    • Table 1. Comparison of clinical imaging modalities used in nanotheranostice[6]

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      Table 1. Comparison of clinical imaging modalities used in nanotheranostice[6]

      ModalityAdvantageLimitationDetection
      MRIHigh spatial resolution, high tissuepenetration depthRelatively low sensitivity, high cost,long imaging time, quantificationMagnetic field
      CTHigh spatial resolutionHigh costX ray
      PETUnlimited tissue penetration, highsensitivity, quantificationHigh costγ ray
      SPECTUnlimited tissue penetration, highsensitivity, quantificationLow spatial resolutionγ ray
      PAIHigh spatial resolution, unlimited tissue penetrationLow sensitivity, low tissuepenetrationUltrasonic signal
      Fluorescence imagingHigh sensitivity, multicolor imagingLow tissue penetration, low spatialresolutionFluorescence
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    Tuxun HAIREGU, Le GUO, Jiayi DING, Jiaqi ZHOU, Xueliang ZHANG, Alifu NUERNISHA. Research Progress of Optical Bioimaging Technology Assisted by Upconversion Fluorescence Probes in Tumor Imaging[J]. Journal of Inorganic Materials, 2025, 40(2): 145

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    Paper Information

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    Received: Jan. 31, 2024

    Accepted: --

    Published Online: Apr. 24, 2025

    The Author Email: Alifu NUERNISHA (nens_xjmu@126.com)

    DOI:10.15541/jim20240058

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