[1] SOKOLOVA V, EPPLE M. Biological and medical applications of calcium phosphate nanoparticles[J]. Chemistry - A European Journal, 7471(2021).

[2] LI B, XU W F, LIAO X L. Research progress in calcium phosphate microspheres for bone defect repair[J]. Journal of Inorganic Materials, 1009(2014).

[3] CHEN X, LI H Z, MA Y H et al. Calcium phosphate-based nanomaterials: preparation, multifunction, and application for bone tissue engineering[J]. Molecules, 4790(2023).

[4] NIE L, HOU M J, WANG T W et al. Nanostructured selenium- doped biphasic calcium phosphate with in situ incorporation of silver for antibacterial applications[J]. Scientific Reports, 13738(2020).

[6] CHEN F, HUANG P, ZHU Y J et al. Multifunctional Eu³⁺/Gd³⁺ dual-doped calcium phosphate vesicle-like nanospheres for sustained drug release and imaging[J]. Biomaterials, 6447(2012).

[7] LI C Y, DING Z Y, HAN Y C. In vitro antibacterial and osteogenic properties of manganese doped nano hydroxyapatite[J]. Journal of Inorganic Materials, 313(2024).

[8] LI C Y, DING Z Y, HAN Y C. Mn-doped nano-hydroxyapatites as theranostic agents with tumor pH-amplified MRI-signal capabilities for guiding photothermal therapy[J]. International Journal of Nanomedicine, 6101(2023).

[9] JACOBS A, RENAUDIN G, CHARBONNEL N et al. Copper- doped biphasic calcium phosphate powders: dopant release, cytotoxicity and antibacterial properties[J]. Materials, 2393(2021).

[10] ZHAO R B, REN X Y, XIE C G et al. Towards understanding the distribution and tumor targeting of sericin regulated spherical calcium phosphate nanoparticles[J]. Microscopy Research and Technique, 321(2017).

[11] KOLLENDA S A, KLOSE J, KNUSCHKE T et al. In vivo biodistribution of calcium phosphate nanoparticles after intravascular, intramuscular, intratumoral, and soft tissue administration in mice investigated by small animal PET/CT[J]. Acta Biomaterialia, 244(2020).

[12] ADAMIANO A, IAFISCO M, SANDRI M et al. On the use of superparamagnetic hydroxyapatite nanoparticles as an agent for magnetic and nuclear in vivo imaging[J]. Acta Biomaterialia, 458(2018).

[13] ÁLAMO P, PALLARÈS V, CÉSPEDES M V et al. Fluorescent dye labeling changes the biodistribution of tumor-targeted nanoparticles[J]. Pharmaceutics, 1004(2020).

[14] ALTINOǦLU E I, RUSSIN T J, KAISER J M et al. Near-infrared emitting fluorophore-doped calcium phosphate nanoparticles for in vivo imaging of human breast cancer[J]. ACS Nano, 2075(2008).

[15] LLOP J, GÓMEZ-VALLEJO V, GIBSON N. Quantitative determination of the biodistribution of nanoparticles: could radiolabeling be the answer?[J]. Nanomedicine, 1035(2013).

[16] JEONG H J, LEE B C, AHN B C et al. Development of drugs and technology for radiation theragnosis[J]. Nuclear Engineering and Technology, 597(2016).

[17] LI P Z, WANG D D, HU J et al. The role of imaging in targeted delivery of nanomedicine for cancer therapy[J]. Advanced Drug Delivery Reviews, 114447(2022).

[18] WANG T T, ZHANG D, SUN D et al. Current status of in vivo bioanalysis of nano drug delivery systems[J]. Journal of Pharmaceutical Analysis, 221(2020).

[19] XIE Y F, PERERA T S H, LI F et al. Quantitative detection method of hydroxyapatite nanoparticles based on Eu³⁺ fluorescent labeling in vitro and in vivo[J]. ACS Applied Materials & Interfaces, 23819(2015).

[20] HAN Y C[J].

[21] DING Z Y, XING Q G, FAN Y R et al. Polyacrylic acid complexes to mineralize ultrasmall europium-doped calcium phosphate nanodots for fluorescent bioimaging[J]. Materials & Design, 111008(2022).

[22] LE A D, WEARING H J, LI D S. Streamlining physiologically- based pharmacokinetic model design for intravenous delivery of nanoparticle drugs[J]. CPT: Pharmacometrics & Systems Pharmacology, 409(2022).

[23] DENG L J, LIU H, MA Y S et al. Endocytosis mechanism in physiologically-based pharmacokinetic modeling of nanoparticles[J]. Toxicology and Applied Pharmacology, 114765(2019).

[24] LI M, ZOU P, TYNER K et al. Physiologically based pharmacokinetic (PBPK) modeling of pharmaceutical nanoparticles[J]. The AAPS Journal, 26(2017).

[25] CHENG Y H, HE C L, RIVIERE J E et al. Meta-analysis of nanoparticle delivery to tumors using a physiologically based pharmacokinetic modeling and simulation approach[J]. ACS Nano, 3075(2020).

[26] ZHANG S Q, MA X Y, SHA D Y et al. A novel strategy for tumor therapy: targeted, PAA-functionalized nano-hydroxyapatite nanomedicine[J]. Journal of Materials Chemistry B, 9589(2020).

[27] CHENG X, XU Y R, ZHANG Y et al. Glucose-targeted hydroxyapatite/indocyanine green hybrid nanoparticles for collaborative tumor therapy[J]. ACS Applied Materials & Interfaces, 37665(2021).

[28] BERNIER A, TOBIAS T, NGUYEN H et al. Vascular and blood compatibility of engineered cationic cellulose nanocrystals in cell-based assays[J]. Nanomaterials, 2072(2021).

[29] SREENIVASAGAN S, SUBRAMANIAN A K, MOHANRAJ K G et al. Assessment of toxicity of green synthesized silver nanoparticle-coated titanium mini-implants with uncoated mini- implants: comparison in an animal model study[J]. The Journal of Contemporary Dental Practice, 944(2024).

[31] KASHANI K, ROSNER M H, OSTERMANN M. Creatinine: from physiology to clinical application[J]. European Journal of Internal Medicine, 9(2020).

[32] ALMEIDA J P M, CHEN A L, FOSTER A et al. In vivo biodistribution of nanoparticles[J]. Nanomedicine, 815(2011).

[34] CHOI J S, CAO J F, NAEEM M et al. Size-controlled biodegradable nanoparticles: preparation and size-dependent cellular uptake and tumor cell growth inhibition[J]. Colloids and Surfaces B: Biointerfaces, 545(2014).

[35] LEDFORD B T, WYATT T G, VANG J et al. Effects of particle size, charge, shape, animal disease state, and sex on the biodistribution of intravenously administered nanoparticles[J]. Particle & Particle Systems Characterization, 2300001(2023).

[36] MELLOR R D, UCHEGBU I F. Ultrasmall-in-nano: why size matters[J]. Nanomaterials, 2476(2022).

[37] WEI Y C, QUAN L, ZHOU C et al. Factors relating to the biodistribution & clearance of nanoparticles & their effects on in vivo application[J]. Nanomedicine, 1495(2018).

[38] TANG L, YANG X J, YIN Q et al. Investigating the optimal size of anticancer nanomedicine[J]. Proceedings of the National Academy of Sciences of the United States of America, 15344(2014).

[39] WANG J, LIU G. Imaging nano-bio interactions in the kidney: toward a better understanding of nanoparticle clearance[J]. Angewandte Chemie International Edition, 3008(2018).

[40] ZHAO Y T, WANG Y, RAN F et al. A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics[J]. Scientific Reports, 4131(2017).