[1] Favaudon V, Caplier L, Monceau V et al. Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice[J]. Science Translational Medicine, 6, 245ra93(2014).

[2] Allen B D, Alaghband Y, Kramár E A et al. Elucidating the neurological mechanism of the Flash effect in juvenile mice exposed to hypofractionated radiotherapy[J]. Neuro-Oncology, 25, 927-939(2023).

[3] [3] Ashraf M R, Melemenidis S, Liu K, et al. MultiInstitutional audit of FLASH conventional dosimetry with a 3D printed anatomically realistic mouse phantom[J]. International Journal of Radiation Oncology · Biology · Physics, 2024, 120(1): 287300.

[4] Zhang Qixian, Gerweck L E, Cascio E et al. Proton FLASH effects on mouse skin at different oxygen tensions[J]. Physics in Medicine & Biology, 68, 055010(2023).

[5] Montay-Gruel P, Petersson K, Jaccard M et al. Irradiation in a flash: unique sparing of memory in mice after whole brain irradiation with dose rates above 100Gy/s[J]. Radiotherapy and Oncology, 124, 365-369(2017).

[6] Montay-Gruel P, Acharya M M, Petersson K et al. Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species[J]. Proceedings of the National Academy of Sciences of the United States of America, 116, 10943-10951(2019).

[7] Röch T F, SZABÓZ, Haffa D et al. A feasibility study of zebrafish embryo irradiation with laser-accelerated protons[J]. Review of Scientific Instruments, 91, 063303(2020).

[8] Beyreuther E, Brand M, Hans S et al. Feasibility of proton FLASH effect tested by zebrafish embryo irradiation[J]. Radiotherapy and Oncology, 139, 46-50(2019).

[9] Vozenin M C, De Fornel P, Petersson K et al. The advantage of FLASH radiotherapy confirmed in mini-pig and cat-cancer patients[J]. Clinical Cancer Research, 25, 35-42(2019).

[10] Bourhis J, Sozzi W J, Jorge P G et al. Treatment of a first patient with FLASH-radiotherapy[J]. Radiotherapy and Oncology, 139, 18-22(2019).

[11] Mascia A E, Daugherty E C, Zhang Yongbin et al. Proton FLASH radiotherapy for the treatment of symptomatic bone metastases: the FAST-01 nonrandomized trial[J]. JAMA Oncology, 9, 62-69(2023).

[12] Daugherty E C, Zhang Y, Xiao Z et al. FLASH radiotherapy for the treatment of symptomatic bone metastases in the thorax (FAST-02): protocol for a prospective study of a novel radiotherapy approach[J]. Radiation Oncology, 19, 34(2024).

[13] Hughes J R, Parsons J L. FLASH radiotherapy: current knowledge and future insights using proton-beam therapy[J]. International Journal of Molecular Sciences, 21, 6492(2020).

[14] Borghini A, Labate L, Piccinini S et al. FLASH radiotherapy: expectations, challenges, and current knowledge[J]. International Journal of Molecular Sciences, 25, 2546(2024).

[15] Vozenin M C, Bourhis J, Durante M. Towards clinical translation of FLASH radiotherapy[J]. Nature Reviews Clinical Oncology, 19, 791-803(2022).

[16] Jolly S, Owen H, Schippers M et al. Technical challenges for FLASH proton therapy[J]. Physica Medica, 78, 71-82(2020).

[17] Manti L, Perozziello F M, Borghesi M et al. The radiobiology of laser-driven particle beams: focus on sub-lethal responses of normal human cells[J]. Journal of Instrumentation, 12, C03084(2017).

[18] Bayart E, Flacco A, Delmas O et al. Fast dose fractionation using ultra-short laser accelerated proton pulses can increase cancer cell mortality, which relies on functional PARP1 protein[J]. Scientific Reports, 9, 10132(2019).

[19] Bin Jianhui, Obst-Huebl L, Mao Jianhua et al. A new platform for ultra-high dose rate radiobiological research using the BELLA PW laser proton beamline[J]. Scientific Reports, 12, 1484(2022).

[20] Shi Ying, Zhang Manzhou, Ouyang Lianhua et al. Design of a rapid-cycling synchrotron for Flash proton therapy[J]. Nuclear Science and Techniques, 34, 145(2023).

[21] [21] Mi S, Kanematsu N, Asakura H, et al. FourDimensional lung treatment planning in layerstacking carbon ion beam treatment: comparison of layerstacking conventional ungatedgated irradiations[J]. International Journal of Radiation Oncology · Biology · Physics, 2011, 80(2): 597607.

[22] Kubo N, Kubota Y, Oike T et al. Skin dose reduction by layer-stacking irradiation in carbon ion radiotherapy for parotid tumors[J]. Frontiers in Oncology, 10, 1396(2020).

[23] Grusell E, Montelius A, Brahme A et al. A general solution to charged particle beam flattening using an optimized dual-scattering-foil technique, with application to proton therapy beams[J]. Physics in Medicine & Biology, 39, 2201-2216(1994).

[24] Wroe A J, Schulte R W, Barnes S et al. Proton beam scattering system optimization for clinical and research applications[J]. Medical Physics, 40, 041702(2013).

[25] Gottschalk B. On the scattering power of radiotherapy protons[J]. Medical Physics, 37, 352-367(2010).

[26] Kainz K K, Antolak J A, Almond P R et al. Dual scattering foil design for poly-energetic electron beams[J]. Physics in Medicine & Biology, 50, 755-767(2005).

[27] Weber U, Kraft G. Design and construction of a ripple filter for a smoothed depth dose distribution in conformal particle therapy[J]. Physics in Medicine & Biology, 44, 2765-2775(1999).

[28] Akagi T, Higashi A, Tsugami H et al. Ridge filter design for proton therapy at Hyogo Ion Beam Medical Center[J]. Physics in Medicine & Biology, 48, N301-N312(2003).

[29] Kang M, Pang D. Commissioning and beam characterization of the first gantry-mounted accelerator pencil beam scanning proton system[J]. Medical Physics, 47, 3496-3510(2020).

[30] [30] Smith B R, Hyer D E, Hill P M, et al. Secondary neutron dose from a dynamic collimation system during intracranial pencil beam scanning proton therapy: a Monte Carlo investigation[J]. International Journal of Radiation Oncology · Biology · Physics, 2019, 103(1): 241250.

[31] Grewal H S, Ahmad S, Jin H. Performance evaluation of adaptive aperture’s static and dynamic collimation in a compact pencil beam scanning proton therapy system: a dosimetric comparison study for multiple disease sites[J]. Medical Dosimetry, 46, 179-187(2021).

[32] Grewal H S, Ahmad S, Jin H. Characterization of penumbra sharpening and scattering by adaptive aperture for a compact pencil beam scanning proton therapy system[J]. Medical Physics, 48, 1508-1519(2021).