Development of distributed arbitrary waveform high voltage pulse generator for controllable electroporation

Yuanhao LIU; Liuxia LI; Yi LIU; Zihuang PENG; Yifan GAO; Fuchang LIN

doi:10.11889/j.0253-3219.2025.hjs.48.240176

NUCLEAR TECHNIQUES, Volume. 48, Issue 1, 010403(2025)

Development of distributed arbitrary waveform high voltage pulse generator for controllable electroporation

Yuanhao LIU, Liuxia LI^*, Yi LIU, Zihuang PENG, Yifan GAO, and Fuchang LIN

State Key Laboratory of Advanced Electromagnetic Technology, School of Electrical and Electronic Engineering, Huazhong University of Science and Technology, Wuhan 430074, China

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References(24)

[1] BAO Jiali, CHEN Xinhua. Past and present of irreversible electroporation for tumor ablation[J]. China Medical Devices, 38, 1-10, 30(2023).

[2] LIU Chunping, YE Ping, ZHANG Mingyue. Research progress in irreversible electroporation ablation for tumors[J]. Journal of Interventional Radiology, 32, 498-502(2023).

[3] ZHENG Zitao, JIN Yamei, ZHANG Lingtao et al. Recent progress on electric field technology in food sterilization[J]. Food Science, 44, 177-184(2023).

[4] CHEN Shougang. Low voltage pulse electric field sterilization material design and environmental purification technology[C](2023).

[5] Elgenedy M A, Simpson J T, Farrag M E. Electroporation for water disinfection: a proof of concept experimentation[C], 1-4(2023).

[6] XU Zhentian, CHEN Luyan, HONG Liangjie et al. Local ablation of triple negative breast cancer in mice by nanosecond pulsed electric fields[J]. China Medical Devices, 38, 11-14, 30(2023).

[7] Ilona G C, Ewa K, Andrzej C. Influence of pulsed electric field on the content of polyphenolic compounds in wine[C], 37-40(2018).

[8] Deng Y D, Gao Y, Men Y K et al. Effect of DC corona on performance of Pulsed electric field pretreatment on waste activated sludge[C], 747-750(2016).

[9] WU Xiao, MI Yan, ZHENG Wei et al. Effect of pulsed electric field on electroporation area of cell membrane[J]. Transactions of China Electrotechnical Society, 38, 3779-3788(2023).

[10] YUE Yaqi, DONG Shoulong, MA Xin et al. Multi-parameter effect analysis of synergistic pulse enhanced irreversible electroporation ablation and experimental study on living animal[J]. High Voltage Technology, 49, 5246-5259(2019).

[11] Arshad R N, Buntat Z, Sidik M A B et al. Proficiency of double-exponential pulse waveform in food treatment through pulsed electric field[C], 218-222(2019).

[12] Qin S, Timoshkin I V, MacLean M et al. Pulsed electric field treatment of saccharomyces cerevisiae using different waveforms[J]. IEEE Transactions on Dielectrics and Electrical Insulation, 22, 1841-1848(2015).

[13] Moonesan M S, Jayaram S H. Effect of pulsewidth on medium temperature rise and microbial inactivation under pulsed electric field food treatment[J]. IEEE Transactions on Industry Applications, 49, 1767-1772(2013).

[14] WU Zhonghang, SHI Haozhi, JIANG Song et al. Development of bipolar pulse generator for cell electroporation[J]. Nuclear Techniques, 44, 100401(2021).

[15] Jiang S, Wang J J, Wang Y G et al. A multilevel pulse generator based on series capacitor structure for cell electroporation[J]. IEEE Transactions on Plasma Science, 48, 4235-4241(2020).

[16] Jiang S, Qiu L W, Li Z et al. A new all-solid-state bipolar high-voltage multilevel generator for dielectric barrier discharge[J]. IEEE Transactions on Plasma Science, 48, 1076-1081(2020).

[17] Elgenedy M A, Massoud A M, Ahmed S et al. A modular multilevel voltage-boosting Marx pulse-waveform generator for electroporation applications[J]. IEEE Transactions on Power Electronics, 34, 10575-10589(2019).

[18] Abdelsalam I, Elgenedy M A, Ahmed S et al. Full-bridge modular multilevel submodule-based high-voltage bipolar pulse generator with low-voltage DC, input for pulsed electric field applications[J]. IEEE Transactions on Plasma Science, 45, 2857-2864(2017).

[19] Mohamed Ali J S, Krishnasamy V. Compact switched capacitor multilevel inverter (CSCMLI) with self-voltage balancing and boosting ability[J]. IEEE Transactions on Power Electronics, 34, 4009-4013(2019).

[20] Imai F, de Novaes Y R. Design and assembly of a bipolar Marx generator based on full-bridge topology applied to electroporation[C], 1-6(2019).

[21] LI Liuxia. Study on characteristics of all-solid-state pulse source under capacitive load[D](2013).

[22] Li L X, Peng Z H, Liu N et al. A distributed high-voltage arbitrary waveform generator based on versatile pulsed power module[J]. IEEE Transactions on Plasma Science, 51, 2309-2320(2023).

[23] Pang L, Ye M T, Li G Q et al. A high voltage multi level arbitrary waveform generator for insulation testing[J]. IEEE Transactions on Dielectrics and Electrical Insulation, 26, 405-411(2019).

[24] LIU Nan. Study on electroporation technology of microalgae based on solid-state Marx power supply[D](2023).

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Yuanhao LIU, Liuxia LI, Yi LIU, Zihuang PENG, Yifan GAO, Fuchang LIN. Development of distributed arbitrary waveform high voltage pulse generator for controllable electroporation[J]. NUCLEAR TECHNIQUES, 2025, 48(1): 010403

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Paper Information

Category: NUCLEAR ELECTRONICS AND INSTRUMENTATION

Received: Apr. 23, 2024

Accepted: --

Published Online: Feb. 26, 2025

The Author Email: Liuxia LI (李柳霞)

DOI:10.11889/j.0253-3219.2025.hjs.48.240176

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology