NUCLEAR TECHNIQUES, Volume. 48, Issue 1, 010403(2025)

Development of distributed arbitrary waveform high voltage pulse generator for controllable electroporation

Yuanhao LIU, Liuxia LI*, Yi LIU, Zihuang PENG, Yifan GAO, and Fuchang LIN
Author Affiliations
  • State Key Laboratory of Advanced Electromagnetic Technology, School of Electrical and Electronic Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
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    Figures & Tables(16)
    Structural diagram of arbitrary high-voltage pulse power supply (a) Centralized structure, (b) Distributed structure
    Diagram of the main circuit topology
    Schematic diagram of drive system
    Schematic diagram of waveform modulation diagram
    Electric shock cup and its electric field distribution
    Simulation circuit of power generator
    Switch time sequences and output diagram of negative polarity sine wave
    Simulation waveform of power output
    Physical photo of a single pulsed power module
    Physical photo of test platform
    Test waveforms of prototype (color online) (a) Simulation waveform, (b) Variable rising trapezoidal wave, (c) Bipolar exponential wave, (d) Gaussian wave
    PI staining results (color online) (a) Positive square wave, (b) Exponential decay wave
    • Table 1. Operation modes

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      Table 1. Operation modes

      工作模式

      Operation modes

      充电模式

      Charging mode

      正极性放电模式

      Positive discharge mode

      负极性放电模式

      Negative discharge mode

      旁路模式

      Bypass mode

      切尾模式

      Chopping mode

      通路示意Path scheme
      开关状态On-off stateOn: T, Sc and SdOff: Sa and SbOn: Sb and ScOff: T, Sa and SdOn: Sa and SdOff: T, Sb and ScOn: ScOff: T, Sa, Sb and SdOn: Sc and SdOff: T, Sa and Sb
      电压OutputUc-Uc0
    • Table 2. Load parameters

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      Table 2. Load parameters

      参数名称 Parameter符号Symbol数值Value
      极板间距 Distance / mml4
      极板高度 Altitude / mmh20
      极板宽度 Width / mmd10
      溶液电导率[24] Electric conductivity / mS·m-1σ8~80
      溶液相对介电常数[24] Relative dielectric constantεr89.99
    • Table 3. Main simulation parameters of generator

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      Table 3. Main simulation parameters of generator

      参数名称

      Parameter

      符号

      Symbol

      数值

      Value

      充电电压

      Charging voltage / V

      U500

      模块数量

      Number of modules

      M2

      模块内基本单元级数

      Number of basic units

      N8

      开关导通电阻

      Switch on resistance / mΩ

      Ron80

      每级储能电容

      Capacitance / μF

      C4
      负载电阻 Resistance / kΩR0.25~2.5
    • Table 4. The experimental data of electroporation

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      Table 4. The experimental data of electroporation

      最大幅值

      Max amplitude / kV·cm-1

      能量

      Energy / J

      电穿孔率

      Electroporation efficiency / %

      正极性方波Positive square wave21.20.4265.25±7.36
      指数衰减波Exponential decay wave21.00.4146.15±4.41
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    Yuanhao LIU, Liuxia LI, Yi LIU, Zihuang PENG, Yifan GAO, Fuchang LIN. Development of distributed arbitrary waveform high voltage pulse generator for controllable electroporation[J]. NUCLEAR TECHNIQUES, 2025, 48(1): 010403

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    Paper Information

    Category: NUCLEAR ELECTRONICS AND INSTRUMENTATION

    Received: Apr. 23, 2024

    Accepted: --

    Published Online: Feb. 26, 2025

    The Author Email: Liuxia LI (李柳霞)

    DOI:10.11889/j.0253-3219.2025.hjs.48.240176

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