Fig. 1. Linear convergence relationship between OCTA decorrelation and iSNR, and OCTA decorrelation variance^[42]. (a) Schematic of OCT dataset; (b) linear convergence relationship between OCTA decorrelation and iSNR, M=99, T=40, N=3960; (c) linear convergence relationship between OCTA decorrelation and iSNR, M=15, T=20, N=300; (d) linear convergence relationship between OCTA decorrelation and iSNR, M=15, <

Fig. 2. OCTA projection based on depth-adaptive threshold and vascular morphology filtering (scale: 400 μm)^[46]. (a) Blood perfusion projection in the shallow layer with global threshold; (b) deep perfusion flow projection with global threshold; (c) blood perfusion projection with depth-adaptive threshold; (d) blood perfusion projection after using depth-adaptive threshold and three-dimensional Hessian matrix shape filtering

Fig. 3. Verification results of HDM in the phantom (scale: 500 μm). (a) OCT structural cross-section of the tissue phantom; (b) OAC of tissue phantom obtained by different methods; (c) statistical distribution of OAC of regions of interest (ROI 1 and ROI 2) , corresponding to the different methods in Fig.3(b); (d) ability of different average methods to distinguish two regions under different average nuclear sizes

Fig. 4. OCTA imaging results of rat cortex (scale: 400 μm)^[21]. (a) OCT structural cross-section; (b) OCTA cross-section; (c) 3D OCTA angiogram; (d) OCTA projection of all depth; (e) projection of shallow blood flow; (f) projection of deep blood flow

Fig. 5. Changes in blood perfusion and OAC during photothrombosis progression (scale: 500 μm). (a) Projections and cross-sections of blood perfusion at different times; (b) average pojections and cross-sections of OAC at different times; (c) changes in blood perfusion ratio in the ischemic and peripheral areas; (d) changes in normalized OAC of ischemic and peripheral areas

Fig. 6. Maximum intensity projections of OCTA in the rat chronic PT stroke model^[21]

Fig. 7. Correlation of the OAC, blood perfusion, and histology in the stroke model in rats^[48]. (a) Average projections of OAC and OAC cross-sections at six representative time points; (b) projections and cross-sections of OCTA blood fusion at each representative time(scale: 500 μm); (c) HE staining results at each representative time; (d) inflammatory cells in the ischemic core; (e) measurement of ischemic or damaged areas based on blood perfusion, OAC,