Chinese Journal of Lasers, Volume. 47, Issue 2, 207010(2020)
Optogenetics Based on Light-Gated Protein-Protein Interactions and Its Applications
Optogenetics is an emerging technique that exploits light to control cells by combining optics and genetics techniques. In optogenetic systems, cells are genetically modified to express photosensitive proteins and consequently become responsive to light pulses. Optogenetics has revolutionized neuroscience research by facilitating selective and rapid control of targeted neurons expressing light-gated ion channels. In addition to light-gated ion channels, photosensitive proteins based on light-gated protein-protein interactions are widely used in optogenetic research. In this review, we discuss these common photosensitive proteins and summarize optogenetic applications in optical control of gene expression, phase separation, biosynthesis, and organelle distribution based on light-gated protein-protein interactions.
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Huang Peiyuan, Song Yutong, Zhang Ning, Zhao Zhihao, Duan Liting. Optogenetics Based on Light-Gated Protein-Protein Interactions and Its Applications[J]. Chinese Journal of Lasers, 2020, 47(2): 207010
Category: biomedical photonics and laser medicine
Received: Oct. 28, 2019
Accepted: --
Published Online: Feb. 21, 2020
The Author Email: Duan Liting (ltduan@cuhk.edu.hk)