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Chinese Journal of Lasers, Volume. 48, Issue 15, 1511001(2021)

Application of Tunable Diode Laser Absorption Spectroscopy in Breath Diagnosis

Liqun Sun*, Mingli Zou, and Xuan Wang
Author Affiliations
  • Department of Precision Instruments, Tsinghua University, Beijing 100084, China
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    AbstractGet PDF(in Chinese)
    Figures&Tables (10)
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    References (136)
    Cited By (11)
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    Figures & Tables(10)
    Schematic diagram of direct absorption method

    Fig. 1. Schematic diagram of direct absorption method

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    Schematic diagram of WMS

    Fig. 2. Schematic diagram of WMS

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    Simulated absorption line intensity of exhaled gas using gas absorption data in HITRAN database

    Fig. 3. Simulated absorption line intensity of exhaled gas using gas absorption data in HITRAN database

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    Acetone absorption data derived from NIST database

    Fig. 4. Acetone absorption data derived from NIST database

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    Three kinds of commonly used MPC. (a) White type[80]; (b) Herriott type[81]; (c) CMPC[83]

    Fig. 5. Three kinds of commonly used MPC. (a) White type[80]; (b) Herriott type[81]; (c) CMPC[83]

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    Carbon isotope detection system in CO2 based on HWG[111]

    Fig. 6. Carbon isotope detection system in CO2 based on HWG[111]

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    Real time exhaled CO detection system based on CMPC[127]

    Fig. 7. Real time exhaled CO detection system based on CMPC[127]

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    Data processing flow of 8.2 μm acetone exhaled gas sensor based on “2f /1f” WMS method[149]

    Fig. 8. Data processing flow of 8.2 μm acetone exhaled gas sensor based on “2f /1f” WMS method[149]

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    • Table 1. Exhaled breath and related diseases

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      Table 1. Exhaled breath and related diseases

      MoleculeDiseaseReference
      Hydrogen (H2)Baby indigestion and gastrointestinal upset[43-44]
      Carbon oxide (CO)Anaemias, respiratory infection, asthma,and hyperbilirubinemia of new-born children[45-48]
      Nitrogen monoxide (NO)Asthma, chronic obstructive lung disease, upper respiratoryinfection, and cancer of digestive organs[6, 49-51]
      Ammonia (NH3)Chronic kidney disease, epilepsy, and cirrhosis[52-53]
      Methane (CH4)Gastrointestinal upset and malabsorption of hydrocarbons[54-55]
      Hydrogen peroxide (H2O2)Reduced breathing function of lungs and uremia[56-57]
      Ethylene (C2H4)Acute myocardial infarction, chronic asthma, and peritonitis[58-59]
      Ethane (C2H6)Smokers and nonsmokers and marker of destruction causedby free radicals[60-61]
      Methanol (CH3OH)Diseases of central nervous system[62]
      Acetone (C3H6O)Diabetes and acute heart failure[10-11]
      Isotopic modifications of CO2Helicobacter pylori infection, liver malfunction,and pancreas malfunction[63-65]
      Carbonyl sulfide (OCS)Cystic fibrosis[66]
      Alkanes (hexane, methylpentane,and benzene derivatives),styrene, heptane derivatives,decane, O-toluidine,hepatenal, and anilineLung cancer[67-69]

    • Table 2. Detection limits of exhaled gases

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      Table 2. Detection limits of exhaled gases

      MoleculeNIRMIRNormal concentration /10-9Reference
      λ /nmDetection limit /10-9λ /nmDetection limit /10-9
      CO21572694442350.0354×107--5×107[94]
      2021189
      CO1568393746020.19<10000 and <20000(for somkers)[95]
      233224
      NO1794124252540.6<35 (for children) and<50 (for adult)[96-97]
      267333
      NH3151251599411250--2900[98]
      95560.5
      CH416543132600.223000--10000[95]
      H2O2----76891.47224--2016 and <4704(for smokers)[56]
      C2H4----31681111--30[99]
      C2H6----33480.32<0.12[100]
      CH3OH----95041.16<400[101]
      OCS24482248280.093--30[95]
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    Liqun Sun, Mingli Zou, Xuan Wang. Application of Tunable Diode Laser Absorption Spectroscopy in Breath Diagnosis[J]. Chinese Journal of Lasers, 2021, 48(15): 1511001

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    Paper Information

    Category: spectroscopy

    Received: Mar. 16, 2021

    Accepted: May. 24, 2021

    Published Online: Aug. 5, 2021

    The Author Email: Liqun Sun (sunlq@mail.tsinghua.edu.cn)

    DOI:10.3788/CJL202148.1511001

    Topics

    laser devices and laser physics
    Lasers and Laser Optics
    Laser physics
    laser manufacturing
    Instrumentation, Measurement and Metrology