Researching | Preclinical evaluation of osteogenic effects of 99Tc-MDP in osteoporosis models

NUCLEAR TECHNIQUES, Volume. 48, Issue 3, 030302(2025)

Preclinical evaluation of osteogenic effects of ⁹⁹Tc-MDP in osteoporosis models

Shengnan REN, Linlin LI, Yun ZHANG, Yaling ZHOU, Tao JIANG, Kejia GAO^*, and Fang FENG^*

Author Affiliations

Department of Nuclear Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China

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References(16)

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[2] Thommesen L, Stunes A K, Monjo M et al. Expression and regulation of resistin in osteoblasts and osteoclasts indicate a role in bone metabolism[J]. Journal of Cellular Biochemistry, 99, 824-834(2006).

[3] LOU Jingjing, LI Tongtong, LIU Xingdang et al. Recent progress of nuclear medicine evaluation of curative effect of 223Ra dichloride treatment on castration- resistant prostate cancer and bone metastases[J]. Nuclear Techniques, 44, 120301(2021).

[4] Shi L J, Ning Y, Xu L L et al. Technetium-99 conjugated with methylene diphosphonate ameliorates glucocorticoid induced osteoporosis by inhibiting osteoclastogenesis[J]. BioMed Research International, 2018, 7902760(2018).

[5] Xie J H, Yuan X Y, Mao W Q et al. 99Tc-methylene diphosphonate treatment is safe and efficacious for osteoporosis in postmenopausal differentiated thyroid cancer patients undergoing TSH suppression: a three-center non-randomized clinical study[J]. Cancer Management and Research, 14, 995-1005(2022).

[6] Su D L, Shen M N, Gu B J et al. 99Tc-methylene diphosphonate improves rheumatoid arthritis disease activity by increasing the frequency of peripheral γδ T cells and CD4+ CD25+ Foxp3+ Tregs[J]. International Journal of Rheumatic Diseases, 19, 586-593(2016).

[7] Smetanin M, Vasilenko E K, Scherpelz R I. Mayak film dosimeter response studies, Part III: application to worker dose assessment[J]. Health Physics, 93, 239-244(2007).

[8] Lai K B, Jin C J, Tu S et al. Intravitreal injection of 99Tc-MDP inhibits the development of laser-induced choroidal neovascularization in rhesus monkeys[J]. Graefe's Archive for Clinical and Experimental Ophthalmology, 252, 1049-1057(2014).

[9] Black D M, Delmas P D, Eastell R et al. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis[J]. The New England Journal of Medicine, 356, 1809-1822(2007).

[10] YAN Wei, WANG Zhonghan, LIU He. Action mechanism of bone remodeling imbalance in osteoporosis and relevant medical treatment strategy[J]. Chinese Journal of Tissue Engineering Research, 24, 4866-4874(2020).

[11] Zhao Y H, Wang L, Liu Y et al. Technetium-99 conjugated with methylene diphosphonate ameliorates ovariectomy-induced osteoporotic phenotype without causing osteonecrosis in the jaw[J]. Calcified Tissue International, 91, 400-408(2012).

[12] CAO Min, LI Yaming, DIAO Yao et al. Advances in the diagnosis and treatment of bone related diseases by bisphosphonates[J]. International Journal of Radiation Medicine and Nuclear Medicine, 44, 119-124(2020).

[13] Wang L M, Gu Q R, Xu Y et al. Effects of yunke (technetium-99 conjugated with methylene diphosphonate; 99Tc-mdp) and/or colloidal chromic phosphate phosphonium-32, alone and in combination, in rats with adjuvant arthritis[J]. Clinical and Experimental Pharmacology and Physiology, 35, 23-28(2008).

[14] MU Rong, CHEN Shi, LI Zhanguo. Therapeutic effect of 99mTc-MDP and its role in proinflammatory cytokines in rheumatoid arthritis[J]. Chinese Journal of Rheumatology, 1, 39-41(2004).

[15] Chen J, Lan Y Y, He Y et al. 99Tc-MDP-induced human osteoblast proliferation, differentiation and expression of osteoprotegerin[J]. Molecular Medicine Reports, 16, 1801-1809(2017).

[16] ZHAO Guoding, GAO Kejia, TIAN Yingmin et al. Experimental study of Gukangling Decoction combined with technetium[99Tc] methylene diphosphonate injection in treating osteoporotic rabbits[J]. Journal of Integrative Medicine, 6, 298-303(2008).

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Shengnan REN, Linlin LI, Yun ZHANG, Yaling ZHOU, Tao JIANG, Kejia GAO, Fang FENG. Preclinical evaluation of osteogenic effects of ⁹⁹Tc-MDP in osteoporosis models[J]. NUCLEAR TECHNIQUES, 2025, 48(3): 030302

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Paper Information

Category: NUCLEAR CHEMISTRY, RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE

Received: Apr. 1, 2024

Accepted: --

Published Online: Apr. 15, 2025

The Author Email: Kejia GAO (高克加), Fang FENG (冯方)

DOI:10.11889/j.0253-3219.2025.hjs.48.240124

Topics

laser devices and laser physics

Lasers and Laser Optics

laser manufacturing

Instrumentation, Measurement and Metrology