Laser microfabrication has unique advantages in medical devices, especially for biomedical compatible materials, due to its properties of ultrashort pulses and high precision. Some new investigations are summarized, such as laser micromachining of biomaterial surface microstructure, laser microfabrication of medical devices and stents as well as rapid prototyping of three-dimensional biomaterial scaffold. It points out the disadvantages of current laser microfabrication technologies in biomedical field and proposes suggestions for further development.