With the characteristics of real-time, high-resolution and non-invasive, optical microscopy can scale from cells, tissues to whole living organisms, which has greatly expanded our understanding to the nature of life. However, due to the limited Space-Bandwidth Product (SBP), it is hard for a conventional optical microscope to achieve a large field of view with a high resolution. This makes it very difficult for microscopic imaging in large field of view biological imaging applications, such as imaging of neural circuits between the synapse of the brain neural networks. Recently, large field-of-view imaging technology has received increasing attention and experienced rapid development. The SBP has been improved ten times or even a hundred times as compared to a traditional optical microscope and the field-of-view has been expanded without sacrificing resolution, which, in turn, has resolved some major problems in biomedical research. This review introduces the progress, characteristics and corresponding biological applications of several typical trans-scale optical imaging techniques in recent years, and gives an outlook on their future development.