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Chinese Journal of Lasers, Volume. 50, Issue 21, 2107112(2023)

Development of an Optical Coherence Tomography System for Mouse Retina Imaging

Rongyao Dong1, Yanhong Ma1, Tianqi Song1, Mingliang Zhou1, Shuai Wang2, and Pengfei Zhang1、*
Author Affiliations
  • 1School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian 116024, Liaoning, China
  • 2Department of Ophthalmology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning, China
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    AbstractGet PDF(in Chinese)
    Figures&Tables (8)
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    References (40)
    Cited By (2)
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    Figures & Tables(8)
    SD-OCT system diagrams. (a) Schematic; (b) SolidWorks 3D structure diagram; (c) Zemax simulation diagram of the optical path of the sample arm

    Fig. 1. SD-OCT system diagrams. (a) Schematic; (b) SolidWorks 3D structure diagram; (c) Zemax simulation diagram of the optical path of the sample arm

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    Spectrometer diagrams. (a) Spectrometer schematic; (b) SolidWorks 3D structure diagram of the spectrometer; (c) Zemax simulation diagram of the optical path of the spectrometer; (d) RMS radius for different wavelength of beams

    Fig. 2. Spectrometer diagrams. (a) Spectrometer schematic; (b) SolidWorks 3D structure diagram of the spectrometer; (c) Zemax simulation diagram of the optical path of the spectrometer; (d) RMS radius for different wavelength of beams

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    Spectrometer design flowchart

    Fig. 3. Spectrometer design flowchart

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    Software calibration flowchart

    Fig. 4. Software calibration flowchart

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    Performance analysis of the spectrometer. (a) Light source spectral curve; (b) k-value linearization curve; (c) spectral data after Fourier transform; (d) the relationship between pixels and actual spatial distance; (e) axial resolution change curve; (f) sensitivity change curve

    Fig. 5. Performance analysis of the spectrometer. (a) Light source spectral curve; (b) k-value linearization curve; (c) spectral data after Fourier transform; (d) the relationship between pixels and actual spatial distance; (e) axial resolution change curve; (f) sensitivity change curve

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    Mouse imaging experiments. (a) Preparation of mouse imaging experiments; (b) OCT image of the black mouse retina; (c) OCT image of the white mouse retina; (d) profile of each layer of the retinal OCT image

    Fig. 6. Mouse imaging experiments. (a) Preparation of mouse imaging experiments; (b) OCT image of the black mouse retina; (c) OCT image of the white mouse retina; (d) profile of each layer of the retinal OCT image

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    • Table 1. Design parameters of the spectrometer

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      Table 1. Design parameters of the spectrometer

      ParameterValue
      Bandwidth Δλ /nm136
      Angle of incidence α /（°）31.59
      Diffraction angle β /（°）31.59
      Grating groove density g /（line·mm-1）1200
      Detector width LD /mm20.48
      Focal length focus fF /mm106.50
      Focal length collimator fC /mm101.6
      Spectral resolution δs /nm0.035

    • Table 2. Thickness of each layer of mouse retina (mean ± standard deviation)

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      Table 2. Thickness of each layer of mouse retina (mean ± standard deviation)

      Layer of the retinaThickness /μm
      Black mouseWhite mouse
      IPL70.08±2.2465.58±2.28
      INL51.97±2.7953.27±1.96
      ONL89.22±2.3980.03±3.91
      IS25.01±1.6521.73±1.12
      IS/OS-CC53.15±1.9356.85±4.15
      Choroid38.97±8.6328.87±8.19
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    Rongyao Dong, Yanhong Ma, Tianqi Song, Mingliang Zhou, Shuai Wang, Pengfei Zhang. Development of an Optical Coherence Tomography System for Mouse Retina Imaging[J]. Chinese Journal of Lasers, 2023, 50(21): 2107112

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    Paper Information

    Category: Biomedical Optical Imaging

    Received: Jun. 21, 2023

    Accepted: Aug. 11, 2023

    Published Online: Nov. 17, 2023

    The Author Email: Pengfei Zhang (pfzhang@dlut.edu.cn)

    DOI:10.3788/CJL230944

    Topics

    laser devices and laser physics
    Lasers and Laser Optics
    Laser physics
    laser manufacturing
    Instrumentation, Measurement and Metrology