International Journal of Digestive Diseases, Volume. 45, Issue 3, 190(2025)

Role and mechanism of trimethylamine oxide in regulating cell ferroptosis through ROS/JNK/GPX4 signaling pathway in slow transmission constipation

CHEN Liping1, HUANG Yebao2, LI Lingbing1, and LIU Chunqiang3、*
Author Affiliations
  • 1Department of Traditional Chinese Medicine Proctology, Liuzhou People's Hospital Affiliated to Guangxi Medical University, Liuzhou 545006, China
  • 1General Department of Traditional Chinese Medicine, the Third Clinical Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Liuzhou Traditional Chinese Medicine Hospital, Liuzhou 545001, China
  • 2Department of Traditional Chinese Medicine Proctology, Liuzhou People's Hospital Affiliated to Guangxi Medical University, Liuzhou 545006, China
  • 3Department of Traditional Chinese Medicine Proctology, People's Hospital of Laibin City, Liuzhou 546100, China
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    References(24)

    [1] [1] Vlismas LJ, Wu W, Ho V. Idiopathic slow transit constipation: pathophysiology, diagnosis, and management[J]. Medicina (Kaunas), 2024, 60(1): 108.

    [2] [2] Bharucha AE, Lacy BE. Mechanisms, evaluation, and management of chronic constipation[J]. Gastroenterology, 2020, 158(5): 1232-1249. e3.

    [3] [3] Qi X, Zhang Y, Guo H, et al. Mechanism and intervention measures of iron side effects on the intestine[J]. Crit Rev Food Sci Nutr, 2020, 60(12): 2113-2125.

    [4] [4] Gatarek P, Kaluzna-Czaplinska J. Trimethylamine N-oxide (TMAO) in human health[J]. EXCLI J, 2021, 20: 301-319.

    [5] [5] Leung DHL, Lim YS, Uma K, et al. Engineering S. oneidensis for performance improvement of microbial fuel cell-a mini review[J]. Appl Biotechnol, 2021, 193(4): 1170-1186.

    [6] [6] Tafesh-Edwards G, Eleftherianos I. JNK signaling in Drosophila immunity and homeostasis[J]. Immunol Lett, 2020, 226: 7-11.

    [7] [7] Lin C, He H, Kim JJ, et al. Osmotic pressure induces translocation of aquaporin-8 by P38 and JNK MAPK signaling pathways in patients with functional constipation[J]. Dig Liver Dis, 2023, 55(8): 1049-1059.

    [8] [8] Deng Z, Fu Z, Yan W, et al. The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate[J]. Food Res Int, 2021, 143: 110273.

    [9] [9] Ma SR, Tong Q, Lin Y, et al. Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota[J]. Signal transduct Target Ther, 2022, 7(1): 207.

    [10] [10] Lou L, Hu D, Chen S, et al. Protective role of JNK inhibitor SP600125 in sepsis-induced acute lung injury[J]. Int J Clin Exp Pathol, 2019, 12(2): 528-538.

    [11] [11] Zhan Y, Wen Y, Du LJ, et al. Effects of Maren pills on the intestinal microflora and short-chain fatty acid profile in drug-induced slow transit constipation model rats[J]. Front Pharmacol, 2022, 13: 804723.

    [12] [12] Jin X, Guan Y, Bai H, et al. Effects of sEA on slow transit constipation through the microbiota-gut-brain axis in rats[J]. Evid Based Complement Alternat Med, 2020, 2020: 8828846.

    [13] [13] Jalandra R, Dalal N, Yadav AK, et al. Emerging role of trimethylamine-N-oxide (TMAO) in colorectal cancer[J]. Appl Microbiol Biotechnol, 2021, 105(20): 7651-7660.

    [14] [14] Liu M, Ding J, Zhang H, et al.Lactobacillus caseiLH23 modulates the immune response and ameliorates DSS-induced colitis via suppressing JNK/p-38 signal pathways and enhancing histone H3K9 acetylation[J]. Food Funct, 2020, 11(6): 5473-5485.

    [15] [15] Ikee R, Sasaki N, Yasuda T, et al. Chronic kidney disease, gut dysbiosis, and constipation: a burdensome triplet[J]. Microorganisms, 2020, 8(12): 1862.

    [16] [16] Liu M, Kong XY, Yao Y, et al. The critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review[J]. Ann Transl Med, 2022, 10(6): 368.

    [17] [17] Mas-Bargues C, Escriv C, Dromant M, et al. Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease[J]. Arch Biochem Biophys, 2021, 709: 108941.

    [18] [18] Islam MN, Rauf A, Fahad FI, et al. Superoxide dismutase: an updated review on its health benefits and industrial applications[J]. Crit Rev Food Sci Nutr, 2022, 62(26): 7282-7300.

    [19] [19] Ursini F, Maiorino M. Lipid peroxidation and ferroptosis: The role of GSH and GPx4[J]. Free Radic Biol Med, 2020, 152: 175-185.

    [20] [20] Zhang W, Liu Y, Liao Y, et al. GPX4, ferroptosis, and diseases[J]. Biomed Pharmacother, 2024, 174: 116512.

    [21] [21] Rochette L, Dogon G, Rigal E, et al. Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis[J]. Int J Mol Sci, 2022, 24(1): 449.

    [22] [22] Li J, Cao F, Yin HL, et al. Ferroptosis: past, present and future[J]. Cell Death Dis, 2020, 11(2): 88.

    [23] [23] Bao H, Wang Y, Xiong H, et al. Mechanism of iron ion homeostasis in intestinal immunity and gut microbiota remodeling[J]. Int J Mol Sci, 2024, 25(2): 727.

    [24] [24] Bardelkov A, oltys J, Moji J. Oxidative stress, inflammation and colorectal cancer: an overview[J]. Antioxidants (Basel), 2023, 12(4): 901.

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    CHEN Liping, HUANG Yebao, LI Lingbing, LIU Chunqiang. Role and mechanism of trimethylamine oxide in regulating cell ferroptosis through ROS/JNK/GPX4 signaling pathway in slow transmission constipation[J]. International Journal of Digestive Diseases, 2025, 45(3): 190

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    Paper Information

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    Received: May. 28, 2024

    Accepted: Aug. 25, 2025

    Published Online: Aug. 25, 2025

    The Author Email: LIU Chunqiang (825756169@qq.com)

    DOI:10.3969/j.issn.1673-534x.2025.03.011

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