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Chinese Journal of Lasers, Volume. 50, Issue 15, 1507101(2023)

Imaging Technologies for Oral Cancer Screening and Diagnosis and Their Development Trends

Yanmei Liang1、*, Zihan Yang1, Jianwei Shang2, Chenlu Liu3, and Jun Zhang4
Author Affiliations
  • 1Institute of Modern Optics, Nankai University, Tianjin Key Laboratory of Micro-Scale Optical Information Science and Technology, Tianjin 300350, China
  • 2Department of Oral Pathology, Tianjin Stomatological Hospital, Department of Oral Pathology, Hospital of Stomatology, Nankai University, Tianjin 300041, China
  • 3Department of Oral Medicine, Tianjin Stomatological Hospital, Department of Oral Medicine, Hospital of Stomatology, Nankai University, Tianjin 300041, China
  • 4Department of Oral-Maxillofacial Surgery, Tianjin Stomatological Hospital, Department of Oral-Maxillofacial Surgery, Hospital of Stomatology Nankai University, Tianjin 300041, China
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    References (113)
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    Figures & Tables(11)
    X-CT imaging of oral cancer. (a) Mandibular involvement of oral squamous cell carcinoma (OSCC)[11]; (b) metastatic lymph node in a rabbit model of OSCC[12]

    Fig. 1. X-CT imaging of oral cancer. (a) Mandibular involvement of oral squamous cell carcinoma (OSCC)[11]; (b) metastatic lymph node in a rabbit model of OSCC[12]

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    MRI imaging of oral cancer. (a) Right tongue OSCC, indicating depth-of-invasion (DOI)[21]; (b) medullary invasion of mandibular bone of OSCC[11]; (c) metastatic cervical lymph node[23]

    Fig. 2. MRI imaging of oral cancer. (a) Right tongue OSCC, indicating depth-of-invasion (DOI)[21]; (b) medullary invasion of mandibular bone of OSCC[11]; (c) metastatic cervical lymph node[23]

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    UI results of oral cancer. (a)(b) Conventional UI results[33]; (c)(d) color DUI results[40]

    Fig. 3. UI results of oral cancer. (a)(b) Conventional UI results[33]; (c)(d) color DUI results[40]

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    Fluorescent images of oral mucosal diseases[51]. (a) OSCC; (b) leukoplakia; (c) lichen planus; (d) stomatitis

    Fig. 4. Fluorescent images of oral mucosal diseases[51]. (a) OSCC; (b) leukoplakia; (c) lichen planus; (d) stomatitis

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    PAI results of hamster buccal pouch model, where high-intensity PAI signal pointed by white arrows is vascularization[62]. (a) Normal cheek tissue; (b) precancerous tissue; (c) OSCC tissue

    Fig. 5. PAI results of hamster buccal pouch model, where high-intensity PAI signal pointed by white arrows is vascularization[62]. (a) Normal cheek tissue; (b) precancerous tissue; (c) OSCC tissue

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    OCT images and corresponding histopathological images of 6 types of oral tumors[80]. (a)(b) Adenoid cystic carcinoma; (c)(d) OSCC; (e)(f) basal cell carcinoma; (g)(h) lipoma; (i)(j) ameloblastoma; (k)(l) pleomorphic adenoma

    Fig. 6. OCT images and corresponding histopathological images of 6 types of oral tumors[80]. (a)(b) Adenoid cystic carcinoma; (c)(d) OSCC; (e)(f) basal cell carcinoma; (g)(h) lipoma; (i)(j) ameloblastoma; (k)(l) pleomorphic adenoma

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    Photos, OCT images and corresponding histopathological images of ex vivo oral leukoplakia[80]. (a)-(c) Verrucous leukoplakia; (d)-(f) homogeneous leukoplakia; (g)-(i) leukoplakia canceration

    Fig. 7. Photos, OCT images and corresponding histopathological images of ex vivo oral leukoplakia[80]. (a)-(c) Verrucous leukoplakia; (d)-(f) homogeneous leukoplakia; (g)-(i) leukoplakia canceration

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    PS-OCT images of normal and cancerous oral tongue tissues. (a) En face birefringence image of normal tongue tissue[86]; (b) en face birefringence image of cancerous tongue tissue[86]; (c) cumulative phase retardation images of normal tongue tissue[87]; (d) cumulative phase retardation images of the boundary between normal and cancerous tongue tissues[87]

    Fig. 8. PS-OCT images of normal and cancerous oral tongue tissues. (a) En face birefringence image of normal tongue tissue[86]; (b) en face birefringence image of cancerous tongue tissue[86]; (c) cumulative phase retardation images of normal tongue tissue[87]; (d) cumulative phase retardation images of the boundary between normal and cancerous tongue tissues[87]

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    Different miniaturized OCT probes for oral imaging. (a) A handheld probe based on two-dimensional galvanometer[88]; (b) a fiber-optic rotary pullback scanning catheter probe[89]; (c) a scanning probe deployed a MEMS mirror at the distal end[90]; (d)(e) a scanning probe with side-view and forward view imaging[91]; (f) a scanning probe deployed a MEMS mirror at the proximal end[92]

    Fig. 9. Different miniaturized OCT probes for oral imaging. (a) A handheld probe based on two-dimensional galvanometer[88]; (b) a fiber-optic rotary pullback scanning catheter probe[89]; (c) a scanning probe deployed a MEMS mirror at the distal end[90]; (d)(e) a scanning probe with side-view and forward view imaging[91]; (f) a scanning probe deployed a MEMS mirror at the proximal end[92]

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    En face images based on optical attenuation model of different oral tissues and their histopathological images[104]. (a)(d) Non-cancerous tissue; (b)(e) boundary between non-cancerous and cancerous tissues; (c)(f) cancerous tissue; (g) three-dimensional reconstruction

    Fig. 10. En face images based on optical attenuation model of different oral tissues and their histopathological images[104]. (a)(d) Non-cancerous tissue; (b)(e) boundary between non-cancerous and cancerous tissues; (c)(f) cancerous tissue; (g) three-dimensional reconstruction

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    • Table 1. Performance parameter comparison of various imaging techniques

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      Table 1. Performance parameter comparison of various imaging techniques

      Imaging techniquePenetration depthResolutionDetection siteMiniaturizationCost
      Non-opticalCTNo limit~1 mm

      Bone involvement，

      metastatic lymph node

      		LowMedium
      MRINo limit~1 mm

      Bone involvement，

      metastatic lymph node

      		LowHigh
      UI<5 cm>30 μm

      Bone involvement，

      metastatic lymph node

      		HighLow
      OpticalFIOral mucosaHighMedium
      PAI<10 mm

      x：1-20 μm

      z：50-500 μm

      		Oral mucosaHighMedium
      OCT1-3 mm1-20 μmOral mucosaHighLow
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    Yanmei Liang, Zihan Yang, Jianwei Shang, Chenlu Liu, Jun Zhang. Imaging Technologies for Oral Cancer Screening and Diagnosis and Their Development Trends[J]. Chinese Journal of Lasers, 2023, 50(15): 1507101

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    Paper Information

    Category: Biomedical Optical Imaging

    Received: Feb. 1, 2023

    Accepted: Mar. 2, 2023

    Published Online: Aug. 8, 2023

    The Author Email: Liang Yanmei (ymliang@nankai.edu.cn)

    DOI:10.3788/CJL230479

    Topics

    laser devices and laser physics
    Lasers and Laser Optics
    Laser physics
    laser manufacturing
    Instrumentation, Measurement and Metrology