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Acta Optica Sinica, Volume. 42, Issue 10, 1012005(2022)

Micro-Force Optical Coherence Elastography for in vivo Corneal Natural Frequency Measurement

Qun Shi1, Jinping Feng2, Ye Zheng3, Yicheng Wang1, Guoqin Ma1, Jia Qin4, Lin An4, Yanping Huang4,5,6, Jingjiang Xu4,5,6, Jing Cai5,6, Yue Shi5, Chongke Ji5,6, and Gongpu Lan4,5,6、*
Author Affiliations
  • 1School of Mechatronic Engineering and Automation, Foshan University, Foshan 528000, Guangdong, China
  • 2Institute of Engineering and Technology, Hubei University of Science and Technology, Xianning 437100, Hubei, China
  • 3International and Continuing Education school, Foshan University, Foshan 528000, Guangdong, China
  • 4Guangdong Weiren Meditech Co., Ltd., Foshan 528000, Guangdong, China
  • 5School of Physics and Optoelectronic Engineering, Foshan University, Foshan 528000, Guangdong, China
  • 6Guangdong-Hong Kong-Macao Intelligent Micro-Nano Optoelectronic Technology Joint Laboratory, Foshan 528000, Guangdong, China
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    Micro-force phase sensitive OCE system. (a) Schematic diagram of OCE system; (b) structural diagram of common-path arm when measuring agar phantom; (c) structural diagram of common-path arm when in vivo measuring human cornea

    Fig. 1. Micro-force phase sensitive OCE system. (a) Schematic diagram of OCE system; (b) structural diagram of common-path arm when measuring agar phantom; (c) structural diagram of common-path arm when in vivo measuring human cornea

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    OCE natural frequency measurement results for agar phantoms with concentration of 1.0%--2.0%. (a) Example of typical response curve of agar phantom with concentration of 2.0% under stimulation force of 20 Pa; (b) fitting result of recovery curve in Fig. 2 (a) fitted by second-order R-Model; (c) spectrum analysis result of damping oscillation part in Fig. 2 (a) by using SDOF-Model; (d) measurement results of natural frequencies of agar phantoms; (e) Bland-Altman consistency evaluation result of two methods

    Fig. 2. OCE natural frequency measurement results for agar phantoms with concentration of 1.0%--2.0%. (a) Example of typical response curve of agar phantom with concentration of 2.0% under stimulation force of 20 Pa; (b) fitting result of recovery curve in Fig. 2 (a) fitted by second-order R-Model; (c) spectrum analysis result of damping oscillation part in Fig. 2 (a) by using SDOF-Model; (d) measurement results of natural frequencies of agar phantoms; (e) Bland-Altman consistency evaluation result of two methods

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    Relationship between measurement results of OCE natural frequency and square root of Young’s modulus of agar phantoms

    Fig. 3. Relationship between measurement results of OCE natural frequency and square root of Young’s modulus of agar phantoms

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    OCE natural frequency measurement results for human cornea in vivo. (a) Corneal displacement dynamics of Subject 1 under stimulation force of 15 Pa; (b) fitting result of recovery curve in Fig. 4 (a) fitted by second-order R-Model; (c) spectrum analysis result of damping oscillation part in Fig. 4 (a) by using SDOF-Model; (d) measurement results of natural frequencies of human cornea; (e) Bland-Altman consistency evaluation result of two methods

    Fig. 4. OCE natural frequency measurement results for human cornea in vivo. (a) Corneal displacement dynamics of Subject 1 under stimulation force of 15 Pa; (b) fitting result of recovery curve in Fig. 4 (a) fitted by second-order R-Model; (c) spectrum analysis result of damping oscillation part in Fig. 4 (a) by using SDOF-Model; (d) measurement results of natural frequencies of human cornea; (e) Bland-Altman consistency evaluation result of two methods

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    • Table 1. Test results of physical properties of agar phantoms

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      Table 1. Test results of physical properties of agar phantoms

      Sample No.Concentration /%Mass /gVolume /cm3Density /(g·cm-3)Young modulus (MMean±MSD) /kPa
      11.030.7634.850.883511.6±24.96
      21.032.1136.230.887529.7±31.85
      31.532.0434.420.931767.6±40.52
      41.531.5133.810.932785.3±35.02
      52.031.0732.610.9531061.4±55.74
      62.031.4632.770.9611083.5±60.26
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    Qun Shi, Jinping Feng, Ye Zheng, Yicheng Wang, Guoqin Ma, Jia Qin, Lin An, Yanping Huang, Jingjiang Xu, Jing Cai, Yue Shi, Chongke Ji, Gongpu Lan. Micro-Force Optical Coherence Elastography for in vivo Corneal Natural Frequency Measurement[J]. Acta Optica Sinica, 2022, 42(10): 1012005

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    Paper Information

    Category: Instrumentation, Measurement and Metrology

    Received: Nov. 2, 2021

    Accepted: Dec. 23, 2021

    Published Online: May. 10, 2022

    The Author Email: Lan Gongpu (langongpu@fosu.edu.cn)

    DOI:10.3788/AOS202242.1012005

    Topics

    laser devices and laser physics
    Lasers and Laser Optics
    Laser physics
    laser manufacturing
    Instrumentation, Measurement and Metrology