Chinese Journal Of Clinical Medicine, Volume. 32, Issue 3, 384(2025)

Neutrophil membrane-coated PLGA nanoparticles promoting the repair of myocardial ischemia-reperfusion injury in mice

CHEN Jing, SONG Yanan, HUANG Zheyong*, and GE Junbo
Author Affiliations
  • Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, State Key Laboratory of Cardiology, National Clinical Research Center for Interventional Medicine, Shanghai Clinical Research Center for Interventional Medicine, Shanghai 200032, China
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    References(24)

    [1] [1] PRABHU S D, FRANGOGIANNIS N G. The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis[J]. Circ Res, 2016, 119(1): 91-112.

    [2] [2] HILGENDORF I, FRANTZ S, FRANGOGIANNIS N G. Repair of the infarcted heart: cellular effectors, molecular mechanisms and therapeutic opportunities[J]. Circ Res, 2024, 134(12): 1718-1751.

    [3] [3] BONAVENTURA A, MORONI F, GOLINO M, et al. IL-1 blockade in cardiovascular disease: an appraisal of the evidence across different inflammatory paradigms[J]. Minerva Cardiol Angiol, 2024, 72(5): 477-488.

    [4] [4] BUCKLEY L F, ABBATE A. Interleukin-1 blockade in cardiovascular diseases: a clinical update[J]. Eur Heart J, 2018, 39(22): 2063-2069.

    [5] [5] RIDKER P M, EVERETT B M, THUREN T, et al. Antiinflammatory therapy with canakinumab for atherosclerotic disease[J]. N Engl J Med, 2017, 377(12): 1119-1131.

    [6] [6] FUNDERBURG N T, SHIVE C L, CHEN Z Y, et al. Interleukin 6 blockade with tocilizumab diminishes indices of inflammation that are linked to mortality in treated human immunodeficiency virus infection[J]. Clin Infect Dis, 2023, 77(2): 272-279.

    [7] [7] ZHANG Q Z, DEHAINI D, ZHANG Y, et al. Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis[J]. Nat Nanotechnol, 2018, 13(12): 1182-1190.

    [8] [8] VOISIN M B, LEONI G, WOODFIN A, et al. Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post-ischemia/reperfusion injury[J]. J Pathol, 2019, 248(1): 88-102.

    [9] [9] HORCKMANS M, RING L, DUCHENE J, et al. Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype[J]. Eur Heart J, 2017, 38(3): 187-197.

    [10] [10] PUHL S L, STEFFENS S. Neutrophils in post-myocardial infarction inflammation: damage vs. resolution?[J]. Front Cardiovasc Med, 2019, 6: 25.

    [11] [11] FRANGOGIANNIS N G. Regulation of the inflammatory response in cardiac repair[J]. Circ Res, 2012, 110(1): 159-173.

    [12] [12] SUN K, LI Y Y, JIN J. A double-edged sword of immuno-microenvironment in cardiac homeostasis and injury repair[J]. Signal Transduct Target Ther, 2021, 6(1): 79.

    [13] [13] SILVIS M J M, KAFFKA GENAAMD DENGLER S E, ODILLE C A, et al. Damage-associated molecular patterns in myocardial infarction and heart transplantation: the road to translational success[J]. Front Immunol, 2020, 11: 599511.

    [14] [14] FRANGOGIANNIS N G. Transforming growth factor- in myocardial disease[J]. Nat Rev Cardiol, 2022, 19(7): 435-455.

    [15] [15] SHINDE A V, DOBACZEWSKI M, DE HAAN J J, et al. Tissue transglutaminase induction in the pressure-overloaded myocardium regulates matrix remodelling[J]. Cardiovasc Res, 2017, 113(8): 892-905.

    [16] [16] LEY K, LAUDANNA C, CYBULSKY M I, et al. Getting to the site of inflammation: the leukocyte adhesion cascade updated[J]. Nat Rev Immunol, 2007, 7(9): 678-689.

    [17] [17] KANG T, ZHU Q Q, WEI D, et al. Nanoparticles coated with neutrophil membranes can effectively treat cancer metastasis[J]. ACS Nano, 2017, 11(2): 1397-1411.

    [18] [18] SADIK C D, KIM N D, LUSTER A D. Neutrophils cascading their way to inflammation[J]. Trends Immunol, 2011, 32(10): 452-460.

    [19] [19] GABRIEL A S, MARTINSSON A, WRETLIND B, et al. IL-6 levels in acute and post myocardial infarction: their relation to CRP levels, infarction size, left ventricular systolic function, and heart failure[J]. Eur J Intern Med, 2004, 15(8): 523-528.

    [20] [20] KEHMEIER E S, LEPPER W, KROPP M, et al. TNF-, myocardial perfusion and function in patients with ST-segment elevation myocardial infarction and primary percutaneous coronary intervention[J]. Clin Res Cardiol, 2012, 101(10): 815-827.

    [21] [21] HAYDEN M S, GHOSH S. Regulation of NF-B by TNF family cytokines[J]. Semin Immunol, 2014, 26(3): 253-266.

    [22] [22] FAN D P, WANG S Q, HUANG R, et al. Light-assisted “nano-neutrophils” with high drug loading for targeted cancer therapy[J]. Int J Nanomed, 2023, 18: 6487-6502.

    [23] [23] SIMPKINS C, MONCURE M, KLEPACZ H, et al. Efficacy and safety of phospholipid nanoparticles (VBI-S) in reversing intractable hypotension in patients with septic shock: a multicentre, open-label, repeated measures, phase 2a clinical pilot trial[J]. EClinicalMedicine, 2024, 68: 102430.

    [24] [24] CHEN Q Y, CHEN Y T, SUN Y L, et al. Leukocyte–mimicking pluronic–lipid nanovesicle hybrids inhibit the growth and metastasis of breast cancer[J]. Nanoscale, 2019, 11(12): 5377-5394.

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    CHEN Jing, SONG Yanan, HUANG Zheyong, GE Junbo. Neutrophil membrane-coated PLGA nanoparticles promoting the repair of myocardial ischemia-reperfusion injury in mice[J]. Chinese Journal Of Clinical Medicine, 2025, 32(3): 384

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    Paper Information

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    Received: Feb. 24, 2025

    Accepted: Aug. 22, 2025

    Published Online: Aug. 22, 2025

    The Author Email: HUANG Zheyong (huang.zheyong@zs-hospital.sh.cn)

    DOI:10.12025/j.issn.1008-6358.2025.20250194

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