Journal of Forensic Medicine, Volume. 41, Issue 2, 144(2025)

The Mechanism of Calcium Handling Proteins and NF-κB in Calcium Dyshomeostasis of Cardiomyocytes Caused by Acute MDMA Exposure

WANG Rong-shuai1,2, HUANG Si-zhe1,3, WANG Yun-yun1, DENG Yan-fei1,4, DING Zi-jiao1,5, ZHANG Jie1, LIU Yong1, REN Liang1, and LIU Liang1、*
Author Affiliations
  • 1Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • 2School of Forensic Medicine, Wannan Medical College, Wuhu 241000, Anhui Province, China
  • 3The Seventh Affiliated Hospital of Southern Medical University, Foshan 528244, Guangdong Province, China
  • 4Jiangxi Provincial Public Security Department, Nanchang 330038, China
  • 5Department of Forensic Medicine, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China
  • show less
    References(17)

    [2] [2] BONSIGNORE A, BARRANCO R, MORANDO A, et al. MDMA induced cardio-toxicity and pathological myocardial effects: A systematic review of experimental data and autopsy findings[J]. Cardiovasc Toxicol, 2019, 19(6): 493−499. doi: 10.1007/s12012-019-09526-9.

    [3] [3] ROXBURGH A, SAM B, KRIIKKU P, et al. Trends in MDMA-related mortality across four countries[J]. Addiction, 2021, 116(11): 3094−3103. doi: 10.1111/add.15493.

    [4] [4] ZHUO L, LIU Q, LIU L, et al. Roles of 3,4-methylenedioxymethamphetamine (MDMA)-induced alteration of connexin43 and intracellular Ca2+ oscillation in its cardiotoxicity[J]. Toxicology, 2013, 310: 61−72. doi: 10.1016/j.tox.2013.05.013.

    [5] [5] GILBERT G, DEMYDENKO K, DRIES E, et al. Calcium signaling in cardiomyocyte function[J]. Cold Spring Harb Perspect Biol, 2020, 12(3): a035428. doi: 10.1101/cshperspect.a035428.

    [6] [6] WOLL K A, VAN PETEGEM F. Calcium-release channels: Structure and function of IP3 receptors and ryanodine receptors[J]. Physiol Rev, 2022, 102(1): 209−268. doi: 10.1152/physrev.00033.2020.

    [7] [7] FUNK F, KRONENBITTER A, HACKERT K, et al. Phospholamban pentamerization increases sensitivity and dynamic range of cardiac relaxation[J]. Cardiovasc Res, 2023, 119(7): 1568−1582. doi: 10.1093/cvr/cvad037.

    [8] [8] SHEN X, ZHANG L, JIANG L, et al. Alteration of sphingosine-1-phosphate with aging induces contractile dysfunction of colonic smooth muscle cells via Ca2+-activated K+ channel (BKCa) upregulation[J]. Neurogastroenterol Motil, 2021, 33(5): e14052. doi: 10.1111/nmo.14052.

    [9] [9] DIAZ-MECO M T, MOSCAT J. The atypical PKCs in inflammation: NF-B and beyond[J]. Immunol Rev, 2012, 246(1): 154−167. doi: 10.1111/j.1600-065X.2012.01093.x.

    [10] [10] COSTA G, GOEMBIOWSKA K. Neurotoxicity of MDMA: Main effects and mechanisms[J]. Exp Neurol, 2022, 347: 113894. doi: 10.1016/j.expneurol.2021.113894.

    [12] [12] DOWLING G P, MCDONOUGH E T 3RD, BOST R O. ‘Eve’ and ‘Ecstasy’. A report of five deaths associated with the use of MDEA and MDMA[J]. JAMA, 1987, 257(12): 1615−1617. doi: 10.1001/jama.257.12.1615.

    [13] [13] FONSECA D A, RIBEIRO D M, TAPADAS M, et al. Ecstasy (3,4-methylenedioxymethamphetamine): Cardiovascular effects and mechanisms[J]. Eur J Pharmacol, 2021, 903: 174156. doi: 10.1016/j.ejphar.2021.174156.

    [14] [14] DOMINIC P, AHMAD J, AWWAB H, et al. Stimulant drugs of abuse and cardiac arrhythmias[J]. Circ Arrhythm Electrophysiol, 2022, 15(1): e010273. doi: 10.1161/circep.121.010273.

    [15] [15] CARVALHO M, REMIO F, MILHAZES N, et al. Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro[J]. Chem Res Toxicol, 2004, 17(5): 623−632. doi: 10.1021/tx049960f.

    [16] [16] NEBEL M, SCHWOERER A P, WARSZTA D, et al. Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by -adrenergic stimulation[J]. J Biol Chem, 2013, 288(22): 16017−16030. doi: 10.1074/jbc.M112.441246.

    [17] [17] TIANGCO D A, LATTANZIO F A JR, OSGOOD C J, et al. 3,4-Methylenedioxymethamphetamine activates nuclear factor-kappaB, increases intracellular calcium, and modulates gene transcription in rat heart cells[J]. Cardiovasc Toxicol, 2005, 5(3): 301−310. doi: 10.1385/ct:5:3:301.

    [18] [18] CHENG W, CUI C, LIU G, et al. NF-B, a potential therapeutic target in cardiovascular diseases[J]. Cardiovasc Drugs Ther, 2023, 37(3): 571−584. doi: 10.1007/s10557-022-07362-8.

    [19] [19] BURR S D, STEWART J A JR. Rap1a overlaps the AGE/RAGE signaling cascade to alter expression of -SMA, p-NF-B, and p-PKC- in cardiac fibroblasts isolated from type 2 diabetic mice[J]. Cells, 2021, 10(3): 557. doi: 10.3390/cells10030557.

    Tools

    Get Citation

    Copy Citation Text

    WANG Rong-shuai, HUANG Si-zhe, WANG Yun-yun, DENG Yan-fei, DING Zi-jiao, ZHANG Jie, LIU Yong, REN Liang, LIU Liang. The Mechanism of Calcium Handling Proteins and NF-κB in Calcium Dyshomeostasis of Cardiomyocytes Caused by Acute MDMA Exposure[J]. Journal of Forensic Medicine, 2025, 41(2): 144

    Download Citation

    EndNote(RIS)BibTexPlain Text
    Save article for my favorites
    Paper Information

    Category:

    Received: Apr. 30, 2024

    Accepted: Aug. 25, 2025

    Published Online: Aug. 25, 2025

    The Author Email: LIU Liang (liuliang@mails.tjmu.edu.cn)

    DOI:10.12116/j.issn.1004-5619.2024.440503

    Topics