Chinese Journal of Lasers, Volume. 50, Issue 15, 1507205(2023)

Noninvasive Optical Monitoring of Lung Based on Monte Carlo Analysis of Visual Chinese Human

Songqi Yang1, Jianghui Guo1,2, and Ting Li1、*
Author Affiliations
  • 1Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China
  • 2School of Optoelectronic Science and Engineering, University of Electronic Science & Technology of China, Chengdu 611731, Sichuan, China
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    Figures & Tables(8)
    VCH-based lung model. (a) VCH original lung image; (b) segmented tissue from the (a) image; (c) five lung lobes; (d) 3D image is an arrangement of 200 processed (b) images
    Five lung lobes detect light source positions. (a) Coordinate system corresponding to Fig.2(b); (b) detection of light source positions in the superior lobe of the left lung, the superior lobe of the right lung, and the middle lobe of the right lung; (c) coordinate system corresponding to Fig.2(d); (d) detection of light source positions in the inferior lobe of the left lung and the inferior lobe of the right lung
    Preliminary experiments of light intensity signals in the lungs. Digits 1-5 indicate the positions of the superior lobe of the right lung, the superior lobe of the left lung, the middle lobe of the right lung, the inferior lobe of the left lung, and the inferior lobe of the right lung, respectively. Digit 6 indicates the cell phone application (upper computer). Digit 7 indicates the NIR detection device. (a) Detection of light signals at positions 1, 2, and 3 of volunteers; (b) detection of light signals at positions 4 and 5 of volunteers
    Light fluence distribution images of the five lung lobes. (a) Inferior lobe of the right lung; (b) superior lobe of the left lung; (c) middle lobe of the right lung; (d) inferior lobe of the left lung; (e) superior lobe of the right lung. The dot “0” and arrow indicate the starting point of the light source and the direction of photon emission, respectively
    Changes in photon absorbance of the five lung lobes with source-detector distance LSD. (a) Photon absorbance of the left lung lobe changes with LSD; (b) photon absorbance of the right lung lobe changes with LSD
    DPF and PPF as a function of source-detector distance LSD for the five lung lobes. (a1)(b1) Inferior lobe of the left lung; (a2)(b2) superior lobe of the left lung; (a3)(b3) inferior lobe of the right lung; (a4)(b4) middle lobe of the right lung; (a5)(b5) superior lobe of the right lung
    Comparison of experimental and simulated light intensities in the lung detection region. (a) Comparison of experimental and simulated light intensities in each lung lobe of 13 volunteers, where “SR” represents superior lobe of the right lung, “IR” represents inferior lobe of the right lung, “MR” represents middle lobe of the right lung, “SL” represents superior lobe of the left lung, and “IL” represents inferior lobe of the left lung; (b) fitting of experimental and simulated values in Fig.7(a), where R2 is the coefficient of determination, * represents P<0.05 and ** represents P<0.01; (c) comparison of experimental and simulated light intensities in 5 lung lobes of a male volunteer; (d) fitting of experimental and simulated values in Fig.7(c)
    • Table 1. Optical properties of tissues at 800 nm

      View table

      Table 1. Optical properties of tissues at 800 nm

      Tissue typenμa /cm-1μs /cm-1gReference
      Skin1.370.20073.70.71518-19
      Muscle1.400.54066.70.93020
      Bone1.430.1102910.93621
      Fat1.330.0831340.90022
      Liver1.400.80056.60.92923
      Lung1.401.00095.00.91020
      Myocardium1.400.9201030.93024-25
      Stomach1.400.78047.00.76126
      Arterial blood1.402.3335220.99027-28
      Venous blood1.402.3384400.99027-28
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    Songqi Yang, Jianghui Guo, Ting Li. Noninvasive Optical Monitoring of Lung Based on Monte Carlo Analysis of Visual Chinese Human[J]. Chinese Journal of Lasers, 2023, 50(15): 1507205

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    Paper Information

    Category: Optical Diagnostics and Therapy

    Received: Feb. 16, 2023

    Accepted: Apr. 25, 2023

    Published Online: Aug. 8, 2023

    The Author Email: Li Ting (liting@bme.cams.cn)

    DOI:10.3788/CJL230532

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