Fig. 1. Computational approaches utilized to study protein liquid-liquid phase separation (LLPS). From left to right are the analytical model, the coarse-grained model (multiple-residues per bead, single-bead per residue and multiple-beads per residue coarse-grained models), and all-atom model. High-resolution descriptions increase the computational cost of the simulations. All-atom model is often impractical for the study of emergent behavior of LLPS^[35].