[1] [1] ESCRIBANO J, CHEN M B, MOEENDARBARY E, et al. Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation［J］. PLoS Computational Biology, 2019, 15(5): e1006395.

[2] [2] KHODAREV N N, YU J, LABAY E, et al. Tumour-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells［J］. Journal of Cell Science, 2003, 116(Pt 6): 1013-1022.

[3] [3] SMITH H A, KANG Y. The metastasis-promoting roles of tumor-associated immune cells［J］. Journal of molecular medicine (Berlin, Germany), 2013, 91(4): 411-429.

[4] [4] PAN Y L, WU Q, LIU R Y, et al. Inhibition effects of gold nanoparticles on proliferation and migration in hepatic carcinoma-conditioned HUVECs［J］. Bioorganic & Medicinal Chemistry Letters, 2014, 24(2): 679-684.

[5] [5] VALASTYAN S, WEINBERG R A. Tumor metastasis: molecular insights and evolving paradigms［J］. Cell, 2011, 147(2): 275-292.

[6] [6] LIN YN, ZHANG C, XIANG P P, et al. Exosomes derived from HeLa cells break down vascular integrity by triggering endoplasmic reticulum stress in endothelial cells［J］. Journal of Extracellular Vesicles, 2020, 9(1): 1722385.

[7] [7] TAVORA B, MEDERER T, WESSEL K J, et al. Tumoural activation of TLR3-SLIT2 axis in endothelium drives metastasis［J］. Nature, 2020, 586(7828): 299-304.

[8] [8] LIU W M, DENNIS J L, GRAVETT A M, et al. Supernatants derived from chemotherapy-treated cancer cell lines can modify angiogenesis［J］. British Journal of Cancer, 2012, 106(5): 896-903.

[9] [9] TU M L, WANG H Q, CHEN L J, et al. Involvement of Akt1/protein kinase Balpha in tumor conditioned medium-induced endothelial cell migration and survival in vitro［J］. Journal of Cancer Research and Clinical Oncology, 2009, 135(11): 1543-1550.

[10] [10] LI C J, GUO S F, SHI T M. Culture supernatants of breast cancer cell line MDA-MB-231 treated with parthenolide inhibit the proliferation, migration, and lumen formation capacity of human umbilical vein endothelial cells［J］. Chinese Medical Journal, 125(12): 2195-2199.

[11] [11] JEAN C, CHEN X L, NAM J O, et al. Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function［J］. Journal of Cell Biology, 2014, 204(2): 247-263.

[12] [12] MELINCOVICI C S, BOSCA A B, ?USMAN S, et al. Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis［J］. Romanian Journal of Morphology and Embryology, 2018, 9(2): 455-467.

[13] [13] PAN Y L, WU Q, QIN L, et al. Gold nanoparticles inhibit VEGF165-induced migration and tube formation of endothelial cells via the Akt pathway［J］. BioMed Research International, 2014, 2014: 418624.

[14] [14] ZEISEL M B, DHAWAN P, BAUMERT T F. Tight junction proteins in gastrointestinal and liver disease［J］. Gut, 2019, 68(3): 547-561.

[15] [15] BRENNAN K, OFFIAH G, MCSHERRY E, et al. Tight junctions: a barrier to the initiation and progression of breast cancer?［J］. Journal of Biomedicine and Biotechnology, 2010, 2010: 460607.

[16] [16] JIA Y, QIN T, ZHANG X, et al. Effect of bevacizumab on the tight junction proteins of vascular endothelial cells［J］. American Journal of Translational Research, 2019, 11(9): 5546-5559.

[17] [17] HUANG N, LIU Y Q, FANG Y S, et al. Gold nanoparticles induce tumor vessel normalization and impair metastasis by inhibiting endothelial Smad2/3 signaling［J］. ACS Nano, 2020, 14(7): 7940-7958.

[18] [18] REYMOND N, DAGUA B B, RIDLEY A J. Crossing the endothelial barrier during metastasis［J］. Nature Reviews Cancer, 2013, 13(12): 858-870.