Journal of Radiation Research and Radiation Processing, Volume. 43, Issue 3, 030301-1(2025)
Dosimetry optimization of hippocampus-avoidance whole-brain radiotherapy using a linear accelerator
Figures & Tables(6)
Fig. 1. Average dose-volume histogram of the PTV and the hippomapus from plans of all MLC angles (color online)
Fig. 2. Dosimetric results of the hippocampus: (a) Dmax of the hippocampus; (b) D100% of the hippocampus; (c) Dmean of the hippocampus
Fig. 3. Transverse, coronal, sagittal dose distributions for (a) 0°/0° MLC, and (b) 60°/300° MLC plans
Fig. 4. Position of the hippocampus and eyeballs of different MLC angles from the collimator eye view (CEV)
Table 1.
Dosimertic results of PTV and OARs (Mean ± SD, n=10)View tableView in ArticleTable 1.
Dosimertic results of PTV and OARs (Mean ± SD, n=10)参数 Parameters 0°/0° 15°/345° 30°/330° 45°/315° 60°/300° 75°/285° 计划靶区(D2%) / Gy
PTV (D2%)
33.25±0.11 33.31±0.10 33.26±0.11 33.29±0.09 33.24±0.11 33.24±0.06 计划靶区(D98%) / Gy
PTV (D98%)
27.99±0.38 27.83±0.82 27.97±0.54 27.83±0.57 27.39±0.43 27.65±0.60 适形性指数 CI 1.05±0.18 1.04±0.17 1.04±0.12 1.04±0.15 1.04±0.16 1.04±0.15 均匀性指数 HI 0.16±0.01 0.17±0.03 0.16±0.02 0.17±0.02 0.18±0.01 0.17±0.02 机器跳数 MUs 1 123±194 1 077±99 990±75 1 038±63 943±72 1 003±96 治疗时间 / min TT 3.82±0.48 3.63±0.24 3.50±0.18 3.81±0.22 3.51±0.21 3.66±0.17 晶状体 / Gy Lens 5.37±0.15 5.38±0.07 5.37±0.07 5.40±0.07 5.40±0.10 5.34±0.09 眼球 / Gy Eyeballs 22.84±1.22 22.87±1.62 23.16±1.56 23.19±1.02 22.37±1.20 22.31±0.92 视神经和视交叉 / Gy
Optic nerves/chiasm
32.83±0.21 32.54±0.50 32.66±0.35 32.61±0.28 32.60±0.28 32.71±0.40 海马体(D100%) / Gy
Hippocampus (D100%)
13.86±2.51 13.88±2.70 12.56±2.55 9.70±2.00 7.62±0.55 8.21±0.57 海马体(Dmax) / Gy
Hippocampus (Dmax)
23.15±1.16 23.02±1.34 22.21±1.81 20.03±1.55 17.39±1.32 19.50±1.12 海马体(Dmean) / Gy
Hippocampus (Dmean)
16.93±2.23 17.13±2.37 15.75±2.53 12.59±2.19 9.89±0.78 11.02±0.82
Table 2.
The comparison of PTV and OARs dosimetric results View tableView in ArticleTable 2.
The comparison of PTV and OARs dosimetric results 参数 Parameters 15°/345° 30°/330° 45°/315° 60°/300° 75°/285° 计划靶区(D2%) PTV (D2%) - - - - - 计划靶区(D98%) PTV (D98%) - - - L** L* 适形性指数 CI - L** L** - L** 均匀性指数 HI - - - H** H* 机器跳数 MUs - L* - L** L* 治疗时间 / min TT - L* - L* - 晶状体 / Gy Lens - - - - - 眼球 / Gy Eyeballs - - - - L* 视神经和视交叉 / Gy
Optic nerves/chiasm
- - - L* - 海马体(D100%) / Gy
Hippocampus (D100%)
- - L** L** L** 海马体(Dmax) / Gy
Hippocampus (Dmax)
- - L** L** L** 海马体(Dmean) / Gy
Hippocampus (Dmean)
- - L** L** L**
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Yu WANG, Deying XU, Yunfeng LIU, Liang YU. Dosimetry optimization of hippocampus-avoidance whole-brain radiotherapy using a linear accelerator[J]. Journal of Radiation Research and Radiation Processing, 2025, 43(3): 030301-1
Paper Information
Category: RADIOBIOLOGY AND RADIOMEDICINE
Received: Nov. 28, 2024
Accepted: Feb. 10, 2025
Published Online: Jul. 7, 2025
The Author Email: Deying XU (许德颖)
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