Visualization of Microenvironment of Meningiomas Based on Multiphoton Microscopy (Invited)

Na Fang; Zanyi Wu; Xingfu Wang; Liwen Hu; Qingyuan Cai; Jianxin Chen

doi:10.3788/CJL241371

Chinese Journal of Lasers, Volume. 52, Issue 9, 0907202(2025)

Visualization of Microenvironment of Meningiomas Based on Multiphoton Microscopy (Invited)

Na Fang1... Zanyi Wu2,**, Xingfu Wang3,***, Liwen Hu3, Qingyuan Cai1 and Jianxin Chen4,* |Show fewer author(s)

Author Affiliations

¹School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350004, Fujian , China

²Department of Neurosurgery, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350004, Fujian , China

³Department of Pathology, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350004, Fujian , China

⁴Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, Fujian , China

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Figures & Tables(7)

Fig. 1. Imaging diagram of multi-photon system

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Fig. 2. Microenvironment of normal dura mater

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Fig. 3. Schematic of microenvironment of common meningioma subtypes

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Fig. 4. Microenvironment of meningiomas

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Fig. 5. Quantitative analysis results of meningioma microenvironment

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Table 1. Information of sample

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Table 1. Information of sample

Tissue type	Number of patients	Number of total imaging sites	Number of locations
Tissue type	Number of patients	Number of total imaging sites	For collagen fiber analysis	For blood vessel analysis
Normal dura mater	3	9	27	27
Meningothelial	7	21	63	63
Fibrous	7	21	63	63
Angiomatous	7	21	63	63
Psammomatous	7	21	63	63
Transitional	7	21	63	63

Table 2. Quantitative data of collagen density and vascular density obtained by image analysis

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Table 2. Quantitative data of collagen density and vascular density obtained by image analysis

Tissue type	Normal	Epithelial	Fibrous	Angiomatous	Transitional	Psammomatous
Collagen density	0.79±0.13	0.15±0.06	0.58±0.24	0.32±0.16	0.11±0.05	0.35±0.12
Vascular density /（4×10⁴ μm²）^-1	0.35±0.11	2.13±0.87	0.71±0.31	4.57±1.83	1.92±1.05	0.91±0.43

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Na Fang, Zanyi Wu, Xingfu Wang, Liwen Hu, Qingyuan Cai, Jianxin Chen. Visualization of Microenvironment of Meningiomas Based on Multiphoton Microscopy (Invited)[J]. Chinese Journal of Lasers, 2025, 52(9): 0907202

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