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Chinese Journal of Lasers, Volume. 45, Issue 2, 207015(2018)

Breath Analysis Using Laser Spectroscopy Techniques: Development and Future

Jiang Chenyu1,2, Sun Meixiu3, Li Yingxin3, and Wang Chuji4、*
Author Affiliations
  • 1[in Chinese]
  • 2[in Chinese]
  • 3[in Chinese]
  • 4[in Chinese]
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    AbstractGet PDF(in Chinese)
    Figures&Tables (9)
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    References (26)
    Cited By (8)
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    Figures & Tables(9)
    Illustration of CRDS technique

    Fig. 1. Illustration of CRDS technique

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    The CRDS breath acetone analyzer I

    Fig. 2. The CRDS breath acetone analyzer I

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    Linear response of the CRDS breath acetone analyzer I

    Fig. 3. Linear response of the CRDS breath acetone analyzer I

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    The reproducibility of the CRDS breath acetone analyzer I

    Fig. 4. The reproducibility of the CRDS breath acetone analyzer I

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    The CRDS breath acetone analyzer II

    Fig. 5. The CRDS breath acetone analyzer II

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    Mean breath acetone concentrations of three subjects

    Fig. 6. Mean breath acetone concentrations of three subjects

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    Linear relation of the breath acetone concentrationwith the mean blood glucose level in 20 TD1 subjects with no ketoacidosis

    Fig. 7. Linear relation of the breath acetone concentrationwith the mean blood glucose level in 20 TD1 subjects with no ketoacidosis

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    • Table 1. Established breath biomarker and their physiological symptoms[7]

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      Table 1. Established breath biomarker and their physiological symptoms[7]

      Breath biomarkerMetabolic disorder /diseaseClassification
      Acetaldehyde (CH3CHO)Alcoholism, liver related diseases, lung cancerDisease
      Acetone [OC(CH3)2]Lung cancer, diabetes, dietary fat losses,congestive heart failure, brain seizure
      Ammonia (NH3)Renal diseases, asthma
      Carbondisulphide (CS2)Schizophrenia, coronary, artery disease
      Carbonyl sulfide (OCS)Liver related diseases
      Hydrogen peroxide (H2O2)Asthma
      Methylated (CH3OH)Nervous system disorder
      Methyl nitrate (CH3NO3)Hyperglycemia intype 1 diabetes
      Nitrogen monoxide (NO)Asthma
      Nitrotyrosine (C9H10N2O5)Asthma, bronchiectasis, hypertension, rhinitis, lung disease
      Pyridine (C5H5N)Periodontal disease
      Sulfur compoundsHepatic diseases and malodor, lung cancer
      Butane (C4H10)Tumor marker in lung cancerMetabolicdisorder
      Carbon monoxide (CO)Oxidative stress, respiratory infection, anaemias
      Carbon dioxide (CO2)(13C-isotopes)Helicobacter pylor, oxidative stress
      Ethane (C2H6)Vitamin E deficiency in children,lipid peroxidation, oxidative stress
      Ethanol (C2H5OH)Production of gut bacteria
      Ethylene (C2H4)Lipid peroxidation, ultra violet radiation damage of skin
      H/D isotopeBody water
      Hydrogen (H2)Indigestion in infants, intestinal upset, colonic fermentation
      Hydrogen cyanide (HCN)Pseudomon asaeruginosa in children affected with cystic fibrosis
      8-isoprostaneOxidative stress
      IsopreneBlood cholesterol
      Methane (CH4)Intestinal problems, colonic fermentation
      Oxygen (O2)Respiration
      Pentane (C5H12)Peroxidation of lipids, liver diseases, schizophrenia,breast cancer, rheumatoid arthritis

    • Table 2. Spectral fingerprints, laser spectroscopic technique, and detection limit of major biomarkers[7]

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      Table 2. Spectral fingerprints, laser spectroscopic technique, and detection limit of major biomarkers[7]

      Breath biomarkers(chemical formula)Spectral fingerprints(UV-MIR) /μmLaser spectroscopictechniqueDetection limitResearchers
      Acetaldehyde (CH3CHO)5.79TDLAS8×10-8Kamat, et al
      Acetone [OC(CH3)2]0.266CRDS5×10-8Wang, et al
      Ammonia (NH3)9-10.7PAS1×10-4Narasimhan, et al
      NH311.0TDLAS1×10-6Lachish, et al
      NH310.0TDLAS3×10-9Manne, et al
      NH310.3TDLAS5×10-9Moskalenko, et al
      NH31.5OFC-CEAS4×10-6Thorpe, et al
      Carbon dioxideand 13C-isotopes4.23PAS7×10-9Herpen, et al
      (CO2 & 13CO2/12CO2)
      CO21.6CRDS3×10-6Crosson, et al
      CO21.59TDLAS1×10-4Weldon, et al
      CO24.9TDLAS5×10-7Moskalenko, et al
      CO24.9CALOS(3.778±0.004)%Halmer, et al
      CO25.2ICOS-McCurdy, et al
      13CO2/12CO21.6CRDSPrecision, 0.2‰Crosson, et al
      13CO2/12CO21.6OFC-CEASPrecision,4.1‰Thorpe, et al
      Carbon monoxide (CO)1.6OFC-CEAS9×10-7Thorpe, et al
      CO4.6TDLAS5×10-7Moskalenko, et al
      CO4.88TDLAS-Lee, et al
      Carbonyl sulfide (OCS)4.86TDLAS1.2×10-9Wysocki, et al
      OCS4.86TDLAS with QC laser3×10-8Roller, et al
      OCS4.9CALOS4.38×10-10Halmer, et al
      Ethane (C2H6)3.4OA-ICOS1.2×10-10Parameswaran, et al
      C2H63.4TDLAS1×10-10Skeldon, et al
      C2H63.3CALOS2.7×10-10Halmer, et al
      C2H63.0CALOS1×10-10Dahnke, et al
      C2H62.6-4.0CALOS5×10-10VonBasum, et al
      C2H63.4TDLAS(0-12)×10-8Patterson, et al
      C2H63.3PAS-Puiu, et al
      Ethylene (C2H4)10.5PAS-Puiu, et al
      C2H49.2-10.8PAS-Dumitras, et al
      Methane (CH4)3.35TDLAS5×10-7Moskalenko, et al
      Nitrogen monoxide (NO)5.2ICOS1×10-9Silva, et al
      NO5.2TDLAS2×10-9Namjou, et al
      NO5.2TDLAS3×10-9Menzle, et al
      NO5.2CRDS7×10-10Kosterev, et al
      NO5.2TDLAS1.5×10-9Roller, et al
      NO5.2ICOS4×10-10McCurdy, et al
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    Jiang Chenyu, Sun Meixiu, Li Yingxin, Wang Chuji. Breath Analysis Using Laser Spectroscopy Techniques: Development and Future[J]. Chinese Journal of Lasers, 2018, 45(2): 207015

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    Paper Information

    Special Issue:

    Received: Sep. 15, 2017

    Accepted: --

    Published Online: Feb. 28, 2018

    The Author Email: Chuji Wang (chujiwang2013@163.com)

    DOI:10.3788/CJL201845.0207015

    Topics

    laser devices and laser physics
    Lasers and Laser Optics
    Laser physics
    laser manufacturing
    Instrumentation, Measurement and Metrology