Journal of Radiation Research and Radiation Processing, Volume. 41, Issue 3, 030305(2023)
Prognostic correlation of lymphocyte-to-monocyte ratio in patients with middle and advanced thoracic tumors with radiotherapy
Figures & Tables(5)
Fig. 1. Changes in the number of lymphocytes/monocytes before and after radiotherapy
Fig. 2. ROC curves of LMR predicting the survival of patients with advanced lung cancer and esophageal cancer (color online)
Fig. 3. Survival curves of patients in high LMR group and low LMR group (color online)
Table 1. Characteristics of patients
View tableView in ArticleTable 1. Characteristics of patients
特征
Characteristics
放疗前 Before RT p值
p value
放疗后 After RT p值
p value
LMR<2.46 LMR≥2.46 LMR<1.07 LMR≥1.07 n 30 44 34 40 性别 Sex, n (%) 0.866 0.068 女Female 5 (6.8%) 8 (10.8%) 3 (4.1%) 10 (13.5%) 男Male 25 (33.8%) 36 (48.6%) 31 (41.9%) 30 (40.5%) 年龄 Age, n (%) 0.037 0.496 ≤70 19 (25.7%) 17 (23%) 18 (24.3%) 18 (24.3%) >70 11 (14.9%) 27 (36.5%) 16 (21.6%) 22 (29.7%) 诊断 Diagnose, n (%) 0.089 0.801 肺癌Lung cancer 19 (25.7%) 19 (25.7%) 18 (24.3%) 20 (27%) 食管癌Esophagus cancer 11 (14.9%) 25 (33.8%) 16 (21.6%) 20 (27%) 临床分期Clinical stage n (%) 0.356 0.619 Ⅱ 10 (13.5%) 12 (16.2%) 4 (5.4%) 6 (8.1%) Ⅲ 2 (2.7%) 8 (10.8%) 12 (16.2%) 10 (13.5%) Ⅳ 18 (24.3%) 24 (32.4%) 18 (24.3%) 24 (32.4%) 病理类型Pathological pattern, n (%) 0.645 0.498 鳞癌Squamous carcinoma 20 (27%) 32 (43.2%) 23 (31.1%) 29 (39.2%) 腺癌Adenocarcinoma 6 (8.1%) 6 (8.1%) 6 (8.1%) 6 (8.1%) 腺鳞癌Adenosquamous carcinoma 1 (1.4%) 1 (1.4%) 2 (2.7%) 0 (0%) 小细胞癌Small cell carcinoma 2 (2.7%) 5 (6.8%) 3 (4.1%) 4 (5.4%) 大细胞癌Large cell carcinoma 1 (1.4%) 0 (0%) 0 (0%) 1 (1.4%) 处方剂量Prescribed dose, n (%) 0.136 0.217 <54 Gy 10 (13.5%) 8 (10.8%) 6 (8.1%) 12 (16.2%) ≥56 Gy 20 (27%) 36 (48.6%) 28 (37.8%) 28 (37.8%) 治疗方案 Treatment plan n (%) 0.033 0.406 联合化疗Combined chemotherapy 13 (17.6%) 30 (40.5%) 18 (24.3%) 25 (33.8%) 单纯放疗Radiotherapy alone 17 (23%) 14 (18.9%) 16 (21.6%) 15 (20.3%)
Table 2. Univariate and multivariate Cox regression analysis on the prognosis of patients with advanced lung cancer and esophageal cancer
View tableView in ArticleTable 2. Univariate and multivariate Cox regression analysis on the prognosis of patients with advanced lung cancer and esophageal cancer
特征
Characteristics
单因素分析 Univariate analysis 多因素分析Multivariate analysis 风险比
Hazard ratio (95% CI)
p值
p value
风险比
Hazard ratio (95% CI)
p值
p value
性别 Sex 0.713 (0.321~1.582) 0.386 年龄 Age 0.848 (0.492~1.460) 0.551 临床分期 Clinical stage 2.602 (1.453~4.662) < 0.001 2.330 (1.181~4.597) 0.015 诊断 Diagnose 0.503 (0.285~0.891) 0.018 0.602 (0.320~1.132) 0.115 病理类型 Pathological pattern 1.172 (0.909~1.512) 0.220 处方剂量 Prescribeddose 0.988 (0.517~1.888) 0.971 治疗方案 Treatment plan 0.156 (0.079~0.308) < 0.001 0.175 (0.080~0.383) < 0.001 放疗前 LMR 0.389 (0.225~0.671) < 0.001 0.442 (0.250~0.782) 0.005 放疗后 LMR 0.581 (0.337~0.999) 0.050 0.537 (0.300~0.963) 0.037
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Jing YANG, Hong ZHOU, Lijun PANG, Yuzhen YIN, Hang YANG. Prognostic correlation of lymphocyte-to-monocyte ratio in patients with middle and advanced thoracic tumors with radiotherapy[J]. Journal of Radiation Research and Radiation Processing, 2023, 41(3): 030305
Paper Information
Category: Research Articles
Received: Nov. 8, 2022
Accepted: May. 16, 2023
Published Online: Jul. 24, 2023
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