[1] [1] ZHAO M, GUAN Z, TANG N,et al. The differences between the water-and alkaline-solublePoria cocospolysaccharide: A review [J]. Int J Biol Macromol, 2023, 235:123925.

[2] [2] XU T, ZHANG H, WANG S,et al. A review on the advances in the extraction methods and structure elucidation ofPoria cocospolysaccharide and its pharmacological activities and drug carrier applications [J]. Int J Biol Macromol, 2022, 217:536-551.

[3] [3] LI X, MA L, ZHANG L. Molecular basis forPoria cocosmushroom polysaccharide used as an antitumor drug in China [J]. Prog Mole Biol Transl Sci, 2019, 163: 263-296.

[4] [4] LAIQING D, GANGLIANG H. The medicinal value of natural and modifiedPoria cocospolysaccharides [J]. Polymer Bulletin, 2024, 81 (18): 16355-16372.

[5] [5] JIANG S, LIANG C, WAN X,et al. Integrative analysis reveals the anti-obesity roles ofPoria cocospolysaccharides through beneficial effects on gut microbiota[J]. J Functional Foods, 2024, 119:106308.

[7] [7] ZHANG WX, HE JQ, ZHENG DP,et al. Immunomodulatory activity and its mechanisms of two polysaccharides from Poria cocos[J]. Molecules, 2023, 29(1): 50.

[8] [8] ZHANG FM, ZHENG H, ZHENG T,et al. Adsorption,in vitrodigestion and human gut microbiota regulation characteristics of threePoria cocospolysaccharides [J]. Food Science and Human Wellness, 2024, 13(3): 1685-1697.

[10] [10] YAN H, ZHOU Y, XIE Z,et al. Pachymaran alleviates acute gouty arthritis by inhibiting NLRP3 inflammasome activation and pyroptosis[J]. Altern Ther Health Med, 2024, 30(10):409-415.

[11] [11] ZHAO Y, FENG X, ZHANG L,et al. Antitumor activity of carboxymethyl pachymaran with different molecular weights based on immunomodulatory and gut microbiota [J]. Nutrients, 2023, 15(21): 4527.

[12] [12] NI X, WANG Q, NING Y,et al. Anemoside B4 targets NEK7 to inhibit NLRP3 inflammasome activation and alleviate MSU-induced acute gouty arthritis by modulating the NF-B signaling pathway [J]. Phytomedicine, 2025, 138: 156407.

[15] [15] YE C, GAO ZH, CHEN KQ,et al. Research on pachymaran to ameliorate CsA-induced immunosuppressive lung injury by regulating microflora metabolism [J]. Microorganisms 2023,11(9): 2249.

[16] [16] YANG J, DONG X, LI B,et al.Poria cocospolysaccharide—functionalized graphene oxide nanosheet induces efficient cancer immunotherapy in mice [J]. Front Bioeng Biotechnol,2023, 10: 1050077.

[19] [19] ZHOU X, WANG J, ZHOU S.Poria cocospolysaccharides improve alcoholic liver disease by interfering with ferroptosis through NRF2 regulation [J]. Aging (Albany NY), 2024,16(7): 6147-6162.

[22] [22] QIN L, HUANG D, HUANG J,et al. Integrated analysis and finding reveal anti-liver cancer targets and mechanisms of pachyman (Poria cocospolysaccharides) [J]. Front Pharmacol, 2021, 12: 742349.

[25] [25] JING TT, GUO YL, WEI YQ. Carboxymethylated pachyman induces ferroptosis in ovarian cancer by suppressing NRF1/HO-1 signaling [J]. Oncol Lett, 2022, 23(5): 161.

[26] [26] KE W, JIAHAO Z, YONGCHAO C,et al. Effects of pachyman in combination with vinorelbine and cisplatin on tumor growth and the expression of egfr and k-ras in mice with lung cancer [J]. Digital Chinese Medicine, 2018, 1 (4):310-315.

[30] [30] LI B, DENG Y, LIN X,et al. Preclinical study of pachyman inducing ferroptosis against ovarian cancer: Biological targets and underlying mechanisms [J]. Food Sci Nutr, 2023, 11(10):5999-6009.

[33] [33] WU K, QIN J, LIU M,et al. Bioinformatics approach and experimental validation reveal the hepatoprotective effect of pachyman against acetaminophen-associated liver injury [J]. Aging (Albany NY), 2023, 15 (17): 8800-8811.

[34] [34] WU K, FAN J, HUANG X,et al. Hepatoprotective effects exerted byPoria cocospolysaccharides against acetaminophen-induced liver injury in mice [J]. Int J Biol Macromol, 2018, 114: 137-142.

[37] [37] TAN Z, ZHANG Q, ZHAO R,et al. A comparative study on the effects of different sources of carboxymethyl Poria polysaccharides on the repair of DSS-induced colitis in mice [J]. Int J Mol Sci, 2023, 24 (10): 9034.