Chinese Journal of Lasers, Volume. 45, Issue 2, 207020(2018)
Progress in Organic Nanomaterials for Laser-Induced Photothermal Therapy of Tumor
Figures & Tables(5)
Fig. 2. Protein-based photothermal agents. (a) Schematic of preparation of HSA-IR825 complex, as well as the unique optical behavior of HSA-IR825; (b) schematic of the covalent conjugation of NIR dye molecules CySCOOH to HSA
Fig. 3. (a) Schematic of preparation of pyropheophorbide-lipid porphysome and (b) transmission electron microscopy images of as-prepared porphysome[26]
Fig. 4. Conjugated polymers for photothermal therapy of cancer. (a) Transition of the emeralidine group of polyaniline to the emeralidine salt, induced by the intracellular oxidative species[27]; (b) schematic of the formation of polypyrrole nanoparticles and morphology of nanoparticles[28]; (c) morphology and absorption spectrum of polydopamine nanoparticles, and their application in photothermal therapy[29]; (d) photoinduced electron transfer (PET) within the confined nanocompartment resulting in enha
Table 1. Typical organic nanoparticles photothermal agents
View tableTable 1. Typical organic nanoparticles photothermal agents
Type Typical sample Size /nm Wavelength of applied laser /nm Advantages and shortcomings Reference NIR dye containing micelles ICG-PL-PEG 17.6 808 Good biocompatibility, but serious photobleaching [18] HF-IR-780 92-121 808 Good biocompatibility and active targeting, but poor photostability [19] IR825-PEG 25 808 Good biocompatibility and relatively good photostability [20] ICG/DOX loaded PLGA- lecithin-PEG NPs 86.3 808 Simultaneous photothermal therapy and drug delivery [21] IR825@C18PMH- PEG-Ce6 107 808 Simultaneous photothermal and photodynamic therapy [22] Protein-based photothermal agents SQ-BSA ~8 680 Good biocompatibility and relatively good photostability [23] HSA-IR825 ~8 808 Good biocompatibility and relatively good photostability. Separated imaging and therapy wavelength channels [24] FRT-IR820 12 808 Good biocompatibility, separated imaging and therapy wavelength channels [25] Porphysome Porphysome 100 658 Good biocompatibility and biodegradability, simultaneous photothermal and photodynamic therapy [26] Conjugated polymers Polyaniline 115.6 808 Robust photostability, but need oxidization or element doping. poor biodegradability [27] Polypyrrole 55 808 Robust photostability, but poor biodegradability [28] Polydopamine 70 808 Good photostability, biocompatibility and biodegradability [29] SPNs 38 808 Good photostability, large photothermal coversion efficiency, turnable absorption wavelength, but poor biodegradability [30] PEDOT∶PSS 80-90 808 Good photostability, but poor biodegradability [31]
Tools
Get Citation
Copy Citation Text
Liang Guohai, Xing Da. Progress in Organic Nanomaterials for Laser-Induced Photothermal Therapy of Tumor[J]. Chinese Journal of Lasers, 2018, 45(2): 207020
Paper Information
Special Issue:
Received: Aug. 15, 2017
Accepted: --
Published Online: Feb. 28, 2018
The Author Email: Guohai Liang (Liangguoh@scnu.edu.cn)
© Copyright 2018-2021 | Chinese Laser Press.
All Rights Reserved 沪ICP备15018463号-20