[1] Denk W, Strickler J H, Webb W W. Two-photon laser scanning fluorescence microscopy[J]. Science, 248, 73-76(1990).

[2] Aparna D U, Mazumder N. Types of advanced optical microscopy techniques for breast cancer research: a review[J]. Lasers in Medical Science, 33, 1849-1858(2018).

[3] Matsui T, Mizuno H, Sudo T et al. Non-labeling multiphoton excitation microscopy as a novel diagnostic tool for discriminating normal tissue and colorectal cancer lesions[J]. Scientific Reports, 7, 6959(2017).

[4] Sun T Y, Haberman A M, Greco V. Preclinical advances with multiphoton microscopy in live imaging of skin cancers[J]. Journal of Investigative Dermatology, 137, 282-287(2017).

[5] Jain M, Robinson B D, Shevchuk M M et al. Multiphoton microscopy: a potential intraoperative tool for the detection of carcinoma in situ in human bladder[J]. Archives of Pathology & Laboratory Medicine, 139, 796-804(2015).

[6] Zhang Z Y, Wang M X, Liu Z H et al. Application of second harmonic generation in biomedical imaging[J]. Chinese Journal of Lasers, 47, 0207008(2020).

[7] Pavlova I P, Nair S S, Lundon D et al. Multiphoton microscopy for identifying collagen signatures associated with biochemical recurrence in prostate cancer patients[J]. Journal of Personalized Medicine, 11, 1061(2021).

[8] Pham T, Banerjee B, Cromey B et al. Feasibility of multimodal multiphoton microscopy to facilitate surgical margin assessment in pancreatic cancer[J]. Applied Optics, 59, G1-G7(2020).

[9] Ustione A, Piston D W. A simple introduction to multiphoton microscopy[J]. Journal of Microscopy, 243, 221-226(2011).

[10] Bloembergen N, Pershan P S. Light waves at the boundary of nonlinear media[J]. Physical Review, 128, 606-622(1962).

[11] Guo Y W, Li Y, Ma Z W. Research on symmetry of BaTiO3 film based on second-harmonic generation technology[J]. Acta Optica Sinica, 41, 0619001(2021).

[12] Rejon C, McCaffrey L[M]. Cell polarity in mammary gland morphogenesis and breast cancer, 187-207(2015).

[13] Hanahan D, Coussens L M. Accessories to the crime: functions of cells recruited to the tumor microenvironment[J]. Cancer Cell, 21, 309-322(2012).

[14] Sun Z, Wang S H, Zhao R C. The roles of mesenchymal stem cells in tumor inflammatory microenvironment[J]. Journal of Hematology & Oncology, 7, 14(2014).

[15] Han X X, Burke R M, Zettel M L et al. Second harmonic properties of tumor collagen: determining the structural relationship between reactive stroma and healthy stroma[J]. Optics Express, 16, 1846-1859(2008).

[16] Burke K, Tang P, Brown E. Second harmonic generation reveals matrix alterations during breast tumor progression[J]. Journal of Biomedical Optics, 18, 031106(2013).

[17] Natal R A, Paiva G R, Pelegati V B et al. Exploring collagen parameters in pure special types of invasive breast cancer[J]. Scientific Reports, 9, 7715(2019).

[18] Provenzano P P, Eliceiri K W, Campbell J M et al. Collagen reorganization at the tumor-stromal interface facilitates local invasion[J]. BMC Medicine, 4, 38(2006).

[19] Conklin M W, Eickhoff J C, Riching K M et al. Aligned collagen is a prognostic signature for survival in human breast carcinoma[J]. The American Journal of Pathology, 178, 1221-1232(2011).

[20] Xi G Q, Guo W H, Kang D Y et al. Large-scale tumor-associated collagen signatures identify high-risk breast cancer patients[J]. Theranostics, 11, 3229-3243(2021).

[21] Sun Y J, Qu Z Y, Li Y H. Study on target detection of breast tumor based on improved mask R-CNN[J]. Acta Optica Sinica, 41, 0212004(2021).

[22] Niu X M, Lü X Q, Gu Y et al. Breast cancer histopathological image classification based on improved ResNeXt[J]. Laser & Optoelectronics Progress, 57, 221021(2020).

[23] Li Z X, Song T, Ge M F et al. Breast cancer classification from histopathological images based on improved inception model[J]. Laser & Optoelectronics Progress, 58, 0817001(2021).

[24] Falzon G, Pearson S, Murison R. Analysis of collagen fibre shape changes in breast cancer[J]. Physics in Medicine and Biology, 53, 6641-6652(2008).

[25] Bredfeldt J S, Liu Y M, Conklin M W et al. Automated quantification of aligned collagen for human breast carcinoma prognosis[J]. Journal of Pathology Informatics, 5, 28(2014).

[26] Majeed H, Okoro C, Kajdacsy-Balla A et al. Quantifying collagen fiber orientation in breast cancer using quantitative phase imaging[J]. Journal of Biomedical Optics, 22, 046004(2017).

[27] Natal R A, Vassallo J, Paiva G R et al. Collagen analysis by second-harmonic generation microscopy predicts outcome of luminal breast cancer[J]. Tumour Biology, 40, 1010428318770953(2018).

[28] Gole L, Yeong J, Lim J C T et al. Quantitative stain-free imaging and digital profiling of collagen structure reveal diverse survival of triple negative breast cancer patients[J]. Breast Cancer Research, 22, 42(2020).

[29] Sprague B L, Vacek P M, Mulrow S E et al. Collagen organization in relation to ductal carcinoma in situ pathology and outcomes[J]. Cancer Epidemiology, Biomarkers & Prevention, 30, 80-88(2021).

[30] Xi G Q, Qiu L D, Xu S Y et al. Computer-assisted quantification of tumor-associated collagen signatures to improve the prognosis prediction of breast cancer[J]. BMC Medicine, 19, 273(2021).

[31] Salgado R, Denkert C, Demaria S et al. The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014[J]. Annals of Oncology, 26, 259-271(2015).

[32] Denkert C, von Minckwitz G, Darb-Esfahani S et al. Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy[J]. The Lancet Oncology, 19, 40-50(2018).

[33] Dieci M V, Mathieu M C, Guarneri V et al. Prognostic and predictive value of tumor-infiltrating lymphocytes in two phase III randomized adjuvant breast cancer trials[J]. Annals of Oncology, 26, 1698-1704(2015).

[34] He J J, Fu F M, Wang W et al. Prognostic value of tumour-infiltrating lymphocytes based on the evaluation of frequency in patients with oestrogen receptor-positive breast cancer[J]. European Journal of Cancer, 154, 217-226(2021).

[35] Catherine L, Gustavo A, Wilks J A et al. Perineural invasion in cancer: a review of the literature[J]. Cancer, 115, 3379-3391(2009).

[36] D’Esposito V, Liguoro D, Ambrosio M R et al. Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5[J]. Oncotarget, 7, 24495-24509(2016).

[37] Richards C H, Mohammed Z, Qayyum T et al. The prognostic value of histological tumor necrosis in solid organ malignant disease: a systematic review[J]. Future Oncology, 7, 1223-1235(2011).