Journal of Environmental and Occupational Medicine, Volume. 42, Issue 7, 846(2025)

Direct and rapid screening of four organic compound metabolites in urine by paper spray mass spectrometry

PAN Junyu1,2, LIU Mengmeng1, and ZENG Qiang1,2、*
Author Affiliations
  • 1Institute for Occupational Health, Tianjin Center for Disease Control and Prevention, Tianjin 300011, China
  • 2School of Public Health, Tianjin Medical University, Tianjin 300070, China
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    References(13)

    [6] [6] LAJIN B, OBERMAYER-PIETSCH B, GOESSLER W. Rapid determination of hydrogen sulfide-related metabolites in human urine by UHPLC-ESI-MS/MS with fluorinated ion-pairing reagents[J]. J Chromatogr B, 2022, 1196: 123198.

    [7] [7] BAHRAMI M, PIRMOHAMMADI Z, BAHRAMI A. A review of new adsorbents for separation of BTEX biomarkers[J]. Biomed Chromatogr, 2021, 35(9): e5131.

    [8] [8] KOHN E, BARCHEL D, GOLIK A, et al. Analysis of 10 urinary BTEX metabolites using LC-MS/MS[J]. Biomed Chromatogr, 2022, 36(4): e5302.

    [10] [10] SINGH L, KUMAR A, AGARWAL T. Study of influential parameters for determination of polycyclic aromatic hydrocarbons (PAHs) on a non-specific C18 column by high-pressure liquid chromatography[J]. Food Anal Methods, 2022, 15(6): 1626-1637.

    [13] [13] WANG H, LIU J, COOKS R G, et al. Paper spray for direct analysis of complex mixtures using mass spectrometry[J]. Angew Chem Int Ed, 2010, 49(5): 877-880.

    [14] [14] RYDBERG M, BRUENING M L, MANICKE N E. Paper spray mass spectrometry with on-paper electrokinetic manipulations: part-per-trillion detection of per/polyfluoroalkyl substances in water and opioids in urine[J]. Angew Chem Int Ed, 2024, 63(25): e202401729.

    [15] [15] BOUZA M, FOEST D, BRANDT S, et al. Enhanced compound analysis using reactive paper spray mass spectrometry: leveraging Schiff base reaction for amino acid detection[J]. Anal Chem, 2024, 96(13): 5289-5297.

    [19] [19] VANDERGRIFT G W, GILL C G. Paper spray mass spectrometry: a new drug checking tool for harm reduction in the opioid overdose crisis[J]. J Mass Spectrom, 2019, 54(9): 729-737.

    [20] [20] ZHENG Y, HUANG Y, ZUO Q, et al. On-demand portable paper-based electrospray ionization mass spectrometry for high-sensitivity analysis of complex samples[J]. Anal Chem, 2023, 95(14): 6163-6171.

    [21] [21] AMADOR V S, MOREIRA J S, AUGUSTI R, et al. Direct coupling of paper spray mass spectrometry and four-phase electroextraction sample preparation[J]. Analyst, 2021, 146(3): 1057-1064.

    [22] [22] VEGA C, SPENCE C, ZHANG C, et al. Ionization suppression and recovery in direct biofluid analysis using paper spray mass spectrometry[J]. J Am Soc Mass Spectrom, 2016, 27(4): 726-734.

    [23] [23] YANG Q, WANG H, MAAS J D, et al. Paper spray ionization devices for direct, biomedical analysis using mass spectrometry[J]. Int J Mass Spectrom, 2012, 312: 201-207.

    [24] [24] LI A, WANG H, OUYANG Z, et al. Paper spray ionization of polar analytes using non-polar solvents[J]. Chem Commun (Camb), 2011, 47(10): 2811-2813.

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    PAN Junyu, LIU Mengmeng, ZENG Qiang. Direct and rapid screening of four organic compound metabolites in urine by paper spray mass spectrometry[J]. Journal of Environmental and Occupational Medicine, 2025, 42(7): 846

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    Paper Information

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    Received: Oct. 30, 2024

    Accepted: Aug. 25, 2025

    Published Online: Aug. 25, 2025

    The Author Email: ZENG Qiang (tjcdczys@163.com)

    DOI:10.11836/jeom24532

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