Laser & Optoelectronics Progress, Volume. 59, Issue 6, 0617015(2022)

Advances on SERS Based on Shifting of Raman Characteristic Peaks

Jianming Yang1, Guojun Weng1、**, Jianjun Li1,2, Jian Zhu1, and Junwu Zhao1、*
Author Affiliations
  • 1Key Laboratory of Biomedical Information Engineering, Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an , Shaanxi 710049, China
  • 2Research Institute of Xi'an Jiaotong University, Hangzhou , Zhejiang 311200, China
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    Figures & Tables(3)
    Mechanism of shifting of Raman characteristic peaks. (a) Mechanical deformation of Raman reporter[17]; (b) charge transfer between molecules[15]
    Applications based on the shifting of Raman characteristic peaks. (a) Highly sensitive detection of liver cancer marker AFP[13]; (b) detection of ctDNA[34]
    • Table 1. Advances on SERS based on the shifting of Raman characteristic peaks

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      Table 1. Advances on SERS based on the shifting of Raman characteristic peaks

      CategoryTargetRaman reporterMechanismContent rangeLimit of detectionReference
      ProteinInfluenza-H1(H1)antigen4-ATPMD2.2 nmol/L12
      H14-ATPMD10 pmol/L29
      c-JunThiophenolMD1×10-9-5×10-6 mol/L5 nmol/L17
      Protein carbonylation4-MBACT0.18-9 nmol/mL30
      P53-protein6-mercaptopurineMD2.5 nmol/L12
      AFP4-MBAMD0.5-1000 ng/mL0.5 ng/mL13
      AFP4-MBAMD10-12-10-8 mol/L10-12 mol/L31
      AFPDSNBMD10-13-10-10 mol/L16
      GPC34-MBAMD10-13-10-10 mol/L16
      PSAGrapheneMD0.05-25 ng/mL0.01 ng/mL32
      Nucleic acidmiR-223DSNBMD10-17-10-13 mol/L10-17 mol/L31
      miR-223DSNBMD10-15 mol/L33
      miR-26a-5p4-MBAMD10-15 mol/L33
      miR-27a-3p6-thio-guanineMD10-15 mol/L33
      ctDNADSNBMD10-8-10-16 mol/L1.2×10-16 mol/L34
      VOCsAcetone2,6-DMPICT35-36
      Butylamine2,6-DMPICT37
      Ammonia2,6-DMPICT2835-36
      CCl42,6-DMPICT2836
      Farnesol2,6-DMPICT76×10-628
      (+)-α-pinene2,6-DMPICT28
      Metal ionsMn2+,Ni2+,Fe2+,Cr3+,Fe3+2,6-DMPICT1 fmol/L28
      Hg2+DASSMD10-3-10-6 mol L-110-8 mol/L14
      Fe3+4-MBNCT

      0.1 pmol/L(free states)

      0.08 μmol/L(protein-bound states)

      38
      Small moleculesMelamineTNBCT10-12 mol/L24
      Glucose4-MBACT10-1-10-6 mol L-110-6 mol L-126
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    Jianming Yang, Guojun Weng, Jianjun Li, Jian Zhu, Junwu Zhao. Advances on SERS Based on Shifting of Raman Characteristic Peaks[J]. Laser & Optoelectronics Progress, 2022, 59(6): 0617015

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    Paper Information

    Category: Medical Optics and Biotechnology

    Received: Aug. 19, 2021

    Accepted: Sep. 24, 2021

    Published Online: Mar. 8, 2022

    The Author Email: Guojun Weng (gjweng@xjtu.edu.cn), Junwu Zhao (nanoptzhao@163.com)

    DOI:10.3788/LOP202259.0617015

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