Chinese Journal of Lasers, Volume. 45, Issue 2, 207025(2018)

Simulation Study on Methodological Feasibility of Diffuse Raman Tomography

Wu Yutong1、*, Jia Mengyu1, Wang Bingyuan1, Zhao Huijuan1,2, and Gao Feng1,2
Author Affiliations
  • 1[in Chinese]
  • 2[in Chinese]
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    Figures & Tables(9)
    Flow chart of the DRT algorithm based on RMC generator
    Phantom model. (a) Three-dimensional geometry; (b) source-detector configuration
    Simulated results of the heterogeneous model provided by the RMC simulator under different integration times
    Multi-wavelength DRT reconstruction results under the three measuring time
    SRM of the multi-wavelength reconstruction results under the three measuring time
    Reconstructed three-dimensional RC distributions of the five components. (a) Lipid; (b) protein; (c) DNA; (d) B-carotene;(e) calcification
    • Table 1. Optical properties of the background and the target

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      Table 1. Optical properties of the background and the target

      TissueExcitation /785 nmRaman /840 nmOther
      μxa /mm-1μxs /mm-1μma /mm-1μms /mm-1ngd /mm
      Epidermis0.19018.9000.13017.6001.40.80.4
      Dermis0.13011.6000.10010.6001.40.81.6
      Subcutaneous0.12011.6000.0979.7001.40.82.0
    • Table 2. RC of the background and target components

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      Table 2. RC of the background and target components

      MaterialLipidProteinDNAB-caroteneCalcificationμr /10-9
      CR-TCR-B0.40∶0.100.50∶0.800.30∶0.100.20∶0.020.06∶0.602.05∶3.96
    • Table 3. RE of the reconstructed RC distributions of the five components

      View table

      Table 3. RE of the reconstructed RC distributions of the five components

      MaterialLipidProteinDNAB-caroteneCalcificationμr /10-9Average
      CR-TCR-B0.400∶0.1000.500∶0.8000.300∶0.1000.200∶0.0020.006∶0.6002.051∶3.967Na
      CR-TDRTCR-BDRT0.400∶0.1700.500∶0.7300.300∶0.1730.200∶0.0470.006∶0.4802.048∶2.978Na
      RE /%23.3023.3025.0022.5020.0051.7022.82
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    Wu Yutong, Jia Mengyu, Wang Bingyuan, Zhao Huijuan, Gao Feng. Simulation Study on Methodological Feasibility of Diffuse Raman Tomography[J]. Chinese Journal of Lasers, 2018, 45(2): 207025

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    Paper Information

    Special Issue:

    Received: Jul. 31, 2017

    Accepted: --

    Published Online: Feb. 28, 2018

    The Author Email: Wu Yutong (wyt1993@tju.edu.cn)

    DOI:10.3788/CJL201845.0207025

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