[2] [2] RICHARDS-WAUGH L L, PRIMERANO D A, DEMENTIEVA Y, et al. Fatal methadone toxicity: Potential role of CYP3A4 genetic polymorphism[J]. J Anal Toxicol, 2014, 38(8): 541−547. doi: 10.1093/jat/bku091.

[3] [3] YUAN J J, HOU J K, ZHANG W, et al.CYP3A4*1Ggenetic polymorphism influences metabolism of fentanyl in human liver microsomes in Chinese patients[J]. Pharmacology, 2015, 96(1/2): 55−60. doi: 10.1159/000433441.

[4] [4] YANG W, ZHAO H, DOU Y, et al.CYP3A4andCYP3A5expression is regulated byCYP3A4*1Gin CRISPR/Cas9-edited HepG2 cells[J]. Drug Metab Dispos, 2023, 51(4): 492−498. doi: 10.1124/dmd.122.001111.

[5] [5] HUNG C C, CHIOU M H, HUANG B H, et al. Impact of genetic polymorphisms inABCB1,CYP2B6,OPRM1,ANKK1andDRD2genes on methadone therapy in Han Chinese patients[J]. Pharmacogenomics, 2011, 12(11): 1525−1533. doi: 10.2217/pgs.11.96.

[6] [6] WANG S C, HO I K, TSOU H H, et al. Functional genetic polymorphisms inCYP2C19gene in relation to cardiac side effects and treatment dose in a methadone maintenance cohort[J]. OMICS, 2013, 17(10): 519−526. doi: 10.1089/omi.2012.0068.

[7] [7] ARORA A, WILLIAMS K. Problem based review: The patient taking methadone[J]. Acute Med, 2013, 12(1): 51−54.

[15] [15] WOLF B C, LAVEZZI W A, SULLIVAN L M, et al. Methadone-related deaths in Palm Beach County[J]. J Forensic Sci, 2004, 49(2): 375−378.

[20] [20] RAMLI F F. Pharmacogenomics biomarkers for personalized methadone maintenance treatment: The mechanism and its potential use[J]. Bosn J Basic Med Sci, 2021, 21(2): 145−154. doi: 10.17305/bjbms.2020.4897.

[21] [21] CHANG Y, FANG W B, LIN S N, et al. Stereoselective metabolism of methadone by human liver microsomes and cDNA-expressed cytochrome P450s: A reconciliation[J]. Basic Clin Pharmacol Toxicol, 2011, 108(1): 55−62. doi: 10.1111/j.1742-7843.2010.00628.x.

[22] [22] AHMAD T, VALENTOVIC M A, RANKIN G O. Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics[J]. Biochem Pharmacol, 2018, 153: 196−204. doi: 10.1016/j.bcp.2018.02.020.