International Journal of Extreme Manufacturing, Volume. 7, Issue 2, 22006(2025)

Neurovascularization strategy: pathfinder and interlocutor for peripheral nerve tissue engineering in a sequential process

Zhan Ning, Li Shuangyang, Liu Zhichao, Zhang Jingyu, Zhang Xiaoting, Peng Lianjie, Tian Lixin, Lin Lining, Qiu Tao, Luo Yaxian, He Yong, Sun Mouyuan, Yu Mengfei, and Wang Huiming
References(133)

[1] [1] Otto G 2021 Repairing nerve damageNat. Rev. Neurosci.22456–7

[2] [2] Zhou W X, Rahman M S U, Sun C M, Li S L, Zhang N Z, Chen H, Han C C, Xu S S and Liu Y 2024 Perspectives on the novel multifunctional nerve guidance conduits: from specific regenerative procedures to motor function rebuildingAdv. Mater.362307805

[3] [3] Jha M Ket al2021 Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after injury in miceJ. Clin. Invest.131e141964

[4] [4] Kornfeld T, Nessler J, Helmer C, Hannemann R, Waldmann K H, Peck C T, Hoffmann P, Brandes G, Vogt P M and Radtke C 2021 Spider silk nerve graft promotes axonal regeneration on long distance nerve defect in a sheep modelBiomaterials271120692

[5] [5] Jstel D, Irl H, Hinterwimmer F, Dehner C, Simson W, Navab N, Schneider G and Ntziachristos V 2023 Spotlight on nerves: portable multispectral optoacoustic imaging of peripheral nerve vascularization and morphologyAdv. Sci.102301322

[6] [6] Novosel E C, Kleinhans C and Kluger P G 2011 Vascularization is the key challenge in tissue engineeringAdv. Drug Deliv. Rev.63300–11

[7] [7] Jain R K, Au P, Tam J, Duda D G and Fukumura D 2005 Engineering vascularized tissueNat. Biotechnol.23821–3

[8] [8] Rouwkema J, Koopman B F J M, Van Blitterswijk C A, Dhert W J A and Malda J 2009 Supply of nutrients to cells in engineered tissuesBiotechnol. Genet. Eng. Rev.26163–78

[9] [9] Carmeliet P and Tessier-Lavigne M 2005 Common mechanisms of nerve and blood vessel wiringNature436193–200

[10] [10] Leventhal C, Rafii S, Rafii D, Shahar A and Goldman S A 1999 Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependymaMol. Cell. Neurosci.13450–64

[11] [11] Cattin A-Let al2015 Macrophage-induced blood vessels guide Schwann cell-mediated regeneration of peripheral nervesCell1621127–39

[12] [12] Yao C, Chen Y P, Wang J, Qian T M, Feng W, Chen Y Y, Mao S S and Yu B 2020 LncRNA BC088259 promotes Schwann cell migration through Vimentin following peripheral nerve injuryGlia68670–9

[13] [13] Brunet Iet al2014 Netrin-1 controls sympathetic arterial innervationJ. Clin. Invest.1243230–40

[14] [14] Chen C M 2012 Predictive effects of structural variation on citation countsJ. Am. Soc. Inf. Sci. Technol.63431–49

[15] [15] Kakinoki R, Nishijima N, Ueba Y, Oka M, Yamamuro T and Nakamura T 1997 Nerve regeneration over a 25 mm gap in rat sciatic nerves using tubes containing blood vessels: the possibility of clinical applicationInt. Orthopaedics21332–6

[16] [16] Wang H Ket al2023Neural tissue-engineered prevascularization in vivoenhances peripheral neuroregeneration via rapid vascular inosculationMater. Today Bio21100718

[17] [17] Shintani K, Uemura T, Takamatsu K, Yokoi T, Onode E, Okada M, Tabata Y and Nakamura H 2020 Evaluation of dual release of stromal cell-derived factor-1 and basic fibroblast growth factor with nerve conduit for peripheral nerve regeneration: an experimental study in miceMicrosurgery40377–86

[18] [18] Shen J J, Wang J Y, Liu X Z, Sun Y, Yin A L, Chai Y M, Zhang K H, Wang C Y and Zheng X Y 2021In situprevascularization strategy with three-dimensional porous conduits for neural tissue engineeringACS Appl. Mater. Interfaces1350785–801

[19] [19] Qian Y, Lin H, Yan Z W, Shi J L and Fan C Y 2021 Functional nanomaterials in peripheral nerve regeneration: scaffold design, chemical principles and microenvironmental remodelingMater. Today51165–87

[20] [20] Song J Q, Lv B H, Chen W C, Ding P and He Y 2023 Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repairInt. J. Extrem. Manuf.5032008

[21] [21] Dong X Het al2021 Aligned microfiber-induced macrophage polarization to guide Schwann-cell-enabled peripheral nerve regenerationBiomaterials272120767

[22] [22] Tomlinson J E,ygelyt E, Grenier J K, Edwards M G and Cheetham J 2018 Temporal changes in macrophage phenotype after peripheral nerve injuryJ. Neuroinflammation15185

[23] [23] Gao Y Set al2024 Advancing neural regeneration via adaptable hydrogels: enriched with Mg2+ and silk fibroin to facilitate endogenous cell infiltration and macrophage polarizationBioact. Mater.33100–13

[24] [24] Yang P X, Peng Y, Dai X, Jie J, Kong D L, Gu X S and Yang Y M 2023 Bionic peptide scaffold in situ polarization and recruitment of M2 macrophages to promote peripheral nerve regenerationBioact. Mater.3085–97

[25] [25] Chen Y L, Chen Z G, Duan J W, Gui L, Li H Y, Liang X Y, Tian X X, Liu K J, Li Y J and Yang J 2022 H2O2-responsive VEGF/NGF gene co-delivery nano-system achieves stable vascularization in ischemic hindlimbsJ. Nanobiotechnol.20145

[26] [26] Zhou Z Z, Liu C R, Guo Y T, Pang Y and Sun W 2024 Engineering vascularized organotypic tissues via module assemblyInt. J. Extrem. Manuf.6012006

[27] [27] Muangsanit P, Roberton V, Costa E and Phillips J B 2021 Engineered aligned endothelial cell structures in tethered collagen hydrogels promote peripheral nerve regenerationActa Biomater.126224–37

[28] [28] Parrinello S, Napoli I, Ribeiro S, Digby P W, Fedorova M, Parkinson D B, Doddrell R D S, Nakayama M, Adams R H and Lloyd A C 2010 EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sortingCell143145–55

[29] [29] Wang G, Lu P J, Qiao P P, Zhang P, Cai X D, Tang L L, Qian T T and Wang H K 2022 Blood vessel remodeling in late stage of vascular network reconstruction is essential for peripheral nerve regenerationBioeng. Transl. Med.7e10361

[30] [30] Quan Qet al2021 Hybrid material mimics a hypoxic environment to promote regeneration of peripheral nervesBiomaterials277121068

[31] [31] Fornasari B E, Zen F, Nato G, Fogli M, Luzzati F, Ronchi G, Raimondo S and Gambarotta G 2022 Blood vessels: the pathway used by Schwann cells to colonize nerve conduitsInt. J. Mol. Sci.232254

[32] [32] Wang H K, Zhu H, Guo Q, Qian T M, Zhang P, Li S Y, Xue C B and Gu X S 2017 Overlapping mechanisms of peripheral nerve regeneration and angiogenesis following sciatic nerve transectionFront. Cell. Neurosci.11323

[33] [33] Fang Z W, Ge X M, Chen X, Xu Y, Yuan W E and Ouyang Y M 2020 Enhancement of sciatic nerve regeneration with dual delivery of vascular endothelial growth factor and nerve growth factor genesJ. Nanobiotechnol.1846

[34] [34] Zhang Y, Qin Y, Chopp M, Li C, Kemper A, Liu X S, Wang X L, Zhang L and Zhang Z G 2020 Ischemic cerebral endothelial cell-derived exosomes promote axonal growthStroke513701–12

[35] [35] Zhang Zet al2022 Crosstalk between PC12 cells and endothelial cells in an artificial neurovascular niche constructed by a dual-functionalized self-assembling peptide nanofiber hydrogelNano Res.151433–45

[36] [36] Kosaka M 1990 Enhancement of rat peripheral nerve regeneration through artery-including silicone tubingExp. Neurol.10769–77

[37] [37] Mitsuzawa Set al2020 Pro-angiogenic scaffold-free Bio three-dimensional conduit developed from human induced pluripotent stem cell-derived mesenchymal stem cells promotes peripheral nerve regenerationSci. Rep.1012034

[38] [38] Thibodeau A, Galbraith T, Fauvel C M, Khuong H T and Berthod F 2022 Repair of peripheral nerve injuries using a prevascularized cell-based tissue-engineered nerve conduitBiomaterials280121269

[39] [39] Ben-Shaul S, Landau S, Merdler U and Levenberg S 2019 Mature vessel networks in engineered tissue promote graft-host anastomosis and prevent graft thrombosisProc. Natl Acad. Sci. USA1162955–60

[40] [40] Kawecki F, Clafshenkel W P, Auger F A, Bourget J M, Fradette J and Devillard R 2018 Self-assembled human osseous cell sheets as living biopapers for the laser-assisted bioprinting of human endothelial cellsBiofabrication10035006

[41] [41] Jun I, Ahmad T, Bak S, Lee J Y, Kim E M, Lee J, Lee Y B, Jeong H, Jeon H and Shin H 2017 Spatially assembled bilayer cell sheets of stem cells and endothelial cells using thermosensitive hydrogels for therapeutic angiogenesisAdv. Healthcare Mater.61601340

[42] [42] Wang C, Yue H B, Feng Q, Xu B Z, Bian L M and Shi P 2018 Injectable nanoreinforced shape-memory hydrogel system for regenerating spinal cord tissue from traumatic injuryACS Appl. Mater. Interfaces1029299–307

[43] [43] Penna V, Munder B, Stark G B and Lang E M 2011 An in vivo engineered nerve conduit-fabrication and experimental study in ratsMicrosurgery31395–400

[44] [44] Zadegan S A, Firouzi M, Nabian M H, Zanjani L O, Ashtiani A M and Kamrani R S 2015 Two-stage nerve graft in severe scar: a time-course study in a rat modelArch. Bone Jt. Surg.382–87

[45] [45] Yapici A K, Bayram Y, Akgun H, Gumus R and Zor F 2017 The effect of in vivo created vascularized neurotube on peripheric nerve regenerationInjury481486–91

[46] [46] Zhang Y G, Huang J H, Hu X Y, Sheng Q S, Zhao W and Luo Z J 2011 Omentum-wrapped scaffold with longitudinally oriented micro-channels promotes axonal regeneration and motor functional recovery in ratsPLoS One6e29184

[47] [47] Chamorro M, Carceller F, Llanos C, Rodrguez-Alvario A, Colmenero C and Burgueo M 1993 The effect of omental wrapping on nerve graft regenerationBr. J. Plast. Surg.46426–9

[48] [48] Sabongi R G, Fernandes M and Dos Santos J B G 2015 Peripheral nerve regeneration with conduits: use of vein tubesNeural Regen. Res.10529–33

[49] [49] Di Benedetto G, Zura G, Mazzucchelli R, Santinelli A, Scarpelli M and Bertani A 1998 Nerve regeneration through a combined autologous conduit (vein plus acellular muscle grafts)Biomaterials19173–81

[50] [50] Dong X Z, Wu P, Yan L S, Liu K, Wei W Y, Cheng Q, Liang X Y, Chen Y and Dai H L 2022 Oriented nanofibrous P(MMD-co-LA)/Deferoxamine nerve scaffold facilitates peripheral nerve regeneration by regulating macrophage phenotype and revascularizationBiomaterials280121288

[51] [51] Wang J, Cheng Y, Wang H Y, Wang Y H, Zhang K H, Fan C Y, Wang H J and Mo X M 2020 Biomimetic and hierarchical nerve conduits from multifunctional nanofibers for guided peripheral nerve regenerationActa Biomater.117180–91

[52] [52] Ma Tet al2020 Oxygen carrier in core-shell fibers synthesized by coaxial electrospinning enhances Schwann cell survival and nerve regenerationTheranostics108957–73

[53] [53] Fadaie M, Mirzaei E, Geramizadeh B and Asvar Z 2018 Incorporation of nanofibrillated chitosan into electrospun PCL nanofibers makes scaffolds with enhanced mechanical and biological propertiesCarbohydrate Polym199628–40

[54] [54] Rebrov I E, Lukanina K I, Grigoriev T E, Bakirov A V, Krasheninnikov S V, Dmitryakov P V, Kamyshinsky R A, Antipova C G, Chvalun S N and Khomich V Y 2021 Enhanced electrospinning: multi-level fiber alignment by control of electrohydrodynamic jet motion for tissue engineeringChem. Eng. J.418126561

[55] [55] Meng Z J, Mu X D, He J K, Zhang J L, Ling R and Li D C 2023 Embedding aligned nanofibrous architectures within 3D-printed polycaprolactone scaffolds for directed cellular infiltration and tissue regenerationInt. J. Extrem. Manuf.5025001

[56] [56] Cui J J, Yu X G, Yu B, Yang X Y, Fu Z Y, Wan J Y, Zhu M, Wang X D and Lin K L 2022 Coaxially fabricated dual-drug loading electrospinning fibrous mat with programmed releasing behavior to boost vascularized bone regenerationAdv. Healthcare Mater.112200571

[57] [57] Cheng Get al2019 Controlled Co-delivery of growth factors through layer-by-layer assembly of core–shell nanofibers for improving bone regenerationACS Nano136372–82

[58] [58] Ma Tet al2022 Sequential oxygen supply system promotes peripheral nerve regeneration by enhancing Schwann cells survival and angiogenesisBiomaterials289121755

[59] [59] Xia B and Lv Y G 2018 Dual-delivery of VEGF and NGF by emulsion electrospun nanofibrous scaffold for peripheral nerve regenerationMater. Sci. Eng.C82253–64

[60] [60] Zhang W, Liu H M, Yan L, Mei X and Hou Z K 2023 Combining emulsion electrospinning with surface functionalization to fabricate multistructural PLA/CS@ZIF-8 nanofiber membranes toward pH-responsive dual drug deliveryInt. J. Biol. Macromol.253126506

[61] [61] Wang B, Barcel X, Von Euw S and Kelly D J 2023 3D printing of mechanically functional meniscal tissue equivalents using high concentration extracellular matrix inksMater. Today Bio20100624

[62] [62] Prasad E, Robertson J, Florence A J and Halbert G W 2023 Expanding the pharmaceutical formulation space in material extrusion 3D printing applicationsAddit. Manuf.77103803

[63] [63] Chen A N, Su J, Li Y J, Zhang H B, Shi Y S, Yan C Z and Lu J 2023 3D/4D printed bio-piezoelectric smart scaffolds for next-generation bone tissue engineeringInt. J. Extrem. Manuf.5032007

[64] [64] Xu W L, Zhang Z, Lu H, Wu Y F, Liu J, Liu S W and Yang W J 2022 Biocompatible polyurethane conduit grafted with vascular endothelial growth factor-loaded hydrogel repairs the peripheral nerve defect in ratsMacromol. Biosci.222100397

[65] [65] Zhu Wet al2018 Rapid continuous 3D printing of customizable peripheral nerve guidance conduitsMater. Today21951–9

[66] [66] Joung D, Lavoie N S, Guo S Z, Park S H, Parr A M and McAlpine M C 2020 3D printed neural regeneration devicesAdv. Funct. Mater.301906237

[67] [67] Qian Y, Song J L, Zhao X T, Chen W, Ouyang Y M, Yuan W E and Fan C Y 2018 3D fabrication with integration molding of a graphene oxide/polycaprolactone nanoscaffold for neurite regeneration and angiogenesisAdv. Sci.51700499

[68] [68] Cai Y Tet al2022 Conductive hydrogel conduits with growth factor gradients for peripheral nerve repair in diabetics with non-suture tapeAdv. Healthcare Mater.112200755

[69] [69] Liu X Y, Wang J J, Wang P, Zhong L, Wang S, Feng Q B, Wei X and Zhou L X 2022 Hypoxia-pretreated mesenchymal stem cell-derived exosomes-loaded low-temperature extrusion 3D-printed implants for neural regeneration after traumatic brain injury in caninesFront. Bioeng. Biotechnol.101025138

[70] [70] Liu S H, Sun L G, Zhang H G, Hu Q X, Wang Y H and Ramalingam M 2021 High-resolution combinatorial 3D printing of gelatin-based biomimetic triple-layered conduits for nerve tissue engineeringInt. J. Biol. Macromol.1661280–91

[71] [71] Wu Y 2021 Electrohydrodynamic jet 3D printing in biomedical applicationsActa Biomater.12821–41

[72] [72] Li Y R, Xie M J, Lv S, Sun Y, Li Z, Gu Z M and He Y 2023 A bionic controllable strain membrane for cell stretching at air–liquid interface inspired by papercuttingInt. J. Extrem. Manuf.5045502

[73] [73] Qian Y, Han Q X, Zhao X T, Li H, Yuan W E and Fan C Y 2019 Asymmetrical 3D nanoceria channel for severe neurological defect regenerationiScience12216–31

[74] [74] Gao Z Q, Yin J, Liu P, Li Q, Zhang R N, Yang H Y and Zhou H Z 2023 Simultaneous multi-material embedded printing for 3D heterogeneous structuresInt. J. Extrem. Manuf.5035001

[75] [75] Wang C, Lai J H, Li K, Zhu S K, Lu B H, Liu J, Tang Y J and Wei Y 2021 Cryogenic 3D printing of dual-delivery scaffolds for improved bone regeneration with enhanced vascularizationBioact. Mater.6137–45

[76] [76] Shoushtari Zadeh Naseri A, Fay C, Nattestad A, Ryder G, Sayyar S, Yue Z L, Liu X, Officer D L and Wallace G G 2024 A novel cryogenic approach to 3D printing cytocompatible, conductive, hydrogel-based inks3D Print. Addit. Manuf.11447–59

[77] [77] Pestana F Met al2018 Comparison of morphological and functional outcomes of mouse sciatic nerve repair with three biodegradable polymer conduits containing poly (lactic acid)Neural Regen. Res.131811–9

[78] [78] Liu Y K, Hu Q X, Dong W P, Liu S H, Zhang H G and Gu Y 2022 Alginate/gelatin-based hydrogel with soy protein/peptide powder for 3D printing tissue-engineering scaffolds to promote angiogenesiMacromol. Biosci.222100413

[79] [79] Wang C Y, Jia Y C, Yang W C, Zhang C, Zhang K H and Chai Y M 2018 Silk fibroin enhances peripheral nerve regeneration by improving vascularization within nerve conduitsJ. Biomed. Mater. Res.A1062070–7

[80] [80] Lee H S, Jeon E Y, Nam J J, Park J H, Choi I C, Kim S H, Chung J J, Lee K, Park J W and Jung Y 2022 Development of a regenerative porous PLCL nerve guidance conduit with swellable hydrogel-based microgrooved surface pattern via 3D printingActa Biomater.141219–32

[81] [81] Zhu Let al2017 Noncovalent bonding of RGD and YIGSR to an electrospun poly (-caprolactone) conduit through peptide self-assembly to synergistically promote sciatic nerve regeneration in ratsAdv. Healthcare Mater.61600860

[82] [82] Huang L, Yang X Q, Deng L L, Ying D F, Lu A, Zhang L N, Yu A X and Duan B 2021 Biocompatible chitin hydrogel incorporated with PEDOT nanoparticles for peripheral nerve repairACS Appl. Mater. Interfaces1316106–17

[83] [83] Dos Santos B P, Garbay B, Fenelon M, Rosselin M, Garanger E, Lecommandoux S, Oliveira H and Amde J 2019 Development of a cell-free and growth factor-free hydrogel capable of inducing angiogenesis and innervation after subcutaneous implantationActa Biomater.99154–67

[84] [84] Li G Cet al2020 Construction of dual-biofunctionalized chitosan/collagen scaffolds for simultaneous neovascularization and nerve regenerationResearch20202603048

[85] [85] Zimoch J, Padial J S, Klar A S, Vallmajo-Martin Q, Meuli M, Biedermann T, Wilson C J, Rowan A and Reichmann E 2018 Polyisocyanopeptide hydrogels: a novel thermo-responsive hydrogel supporting pre-vascularization and the development of organotypic structuresActa Biomater.70129–39

[86] [86] Liu G H, Wu R P, Yang B, Shi Y G, Deng C H, Atala A, Mou S, Criswell T and Zhang Y Y 2020 A cocktail of growth factors released from a heparin hyaluronic-acid hydrogel promotes the myogenic potential of human urine-derived stem cellsin vivo Acta Biomater.10750–64

[87] [87] Liu Jet al2024 Nickel-based metal-organic frameworks promote diabetic wound healing via scavenging reactive oxygen species and enhancing angiogenesisSmall202305076

[88] [88] Parikh S M 2017 The angiopoietin-tie2 signaling axis in systemic inflammationJ. Am. Soc. Nephrol.281973–82

[89] [89] Rao Fet al2020 Aligned chitosan nanofiber hydrogel grafted with peptides mimicking bioactive brain-derived neurotrophic factor and vascular endothelial growth factor repair long-distance sciatic nerve defects in ratsTheranostics101590–603

[90] [90] Hsu R S, Chen P Y, Fang J H, Chen Y Y, Chang C W, Lu Y J and Hu S H 2019 Adaptable microporous hydrogels of propagating NGF-gradient by injectable building blocks for accelerated axonal outgrowthAdv. Sci.61900520

[91] [91] Ikegami Y, Shafiq M, Aishima S and Ijima H 2023 Heparin/growth factors-immobilized aligned electrospun nanofibers promote nerve regeneration in polycaprolactone/gelatin-based nerve guidance conduitsAdv. Fiber Mater.5554–73

[92] [92] Zhao B, Zhao Z H, Ma J X and Ma X L 2019 Modulation of angiogenic potential of tissue-engineered peripheral nerve by covalent incorporation of heparin and loading with vascular endothelial growth factorNeurosci Lett.705259–64

[93] [93] Zhu X Let al2022 FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesisProc. Natl Acad. Sci. USA119e2202631119

[94] [94] Wu X Y, Zhu Y M, Qi Y, Xu W W and Zhai J 2021 Erythropoietin, as a biological macromolecule in modification of tissue engineered constructs: a reviewInt. J. Biol. Macromol.1932332–42

[95] [95] Manto K M, Govindappa P K, Martinazzi B, Han A J, Hegarty J P, Koroneos Z, Talukder M A H and Elfar J C 2022 Erythropoietin-PLGA-PEG as a local treatment to promote functional recovery and neurovascular regeneration after peripheral nerve injuryJ. Nanobiotechnol.20461

[96] [96] Frontini M J, Nong Z X, Gros R, Drangova M, O'Neil C, Rahman M N, Akawi O, Yin H, Ellis C G and Pickering J G 2011 Fibroblast growth factor 9 delivery during angiogenesis produces durable, vasoresponsive microvessels wrapped by smooth muscle cellsNat. Biotechnol.29421–7

[97] [97] Huang Qet al2021 Aligned graphene mesh-supported double network natural hydrogel conduit loaded with netrin-1 for peripheral nerve regenerationACS Appl. Mater. Interfaces13112–22

[98] [98] Yang S Het al2020 Self-assembling peptide hydrogels functionalized with LN-and BDNF-mimicking epitopes synergistically enhance peripheral nerve regenerationTheranostics108227–49

[99] [99] Sanen K, Martens W, Georgiou M, Ameloot M, Lambrichts I and Phillips J 2017 Engineered neural tissue with Schwann cell differentiated human dental pulp stem cells: potential for peripheral nerve repair?J. Tissue Eng. Regen. Med.113362–72

[100] [100] Wu P, Tong Z, Luo L H, Zhao Y N, Chen F X, Li Y P, Huselstein C, Ye Q F, Ye Q S and Chen Y 2021 Comprehensive strategy of conduit guidance combined with VEGF producing Schwann cells accelerates peripheral nerve repairBioact. Mater.63515–27

[101] [101] Namini M S, Ebrahimi-Barough S, Ai J, Jahromi H K, Mikaeiliagah E, Azami M, Bahrami N, Lotfibakhshaiesh N, Saremi J and Shirian S 2023 Tissue-engineered core-shell silk-fibroin/poly-L-lactic acid nerve guidance conduit containing encapsulated exosomes of human endometrial stem cells promotes peripheral nerve regenerationACS Biomater. Sci. Eng.93496–511

[102] [102] Xu W Q, Xu X H, Yao L H, Xue B, Xi H L, Cao X F, Piao G Y, Lin S and Wang X M 2023 VEGFA-modified DPSCs combined with LC-YE-PLGA NGCs promote facial nerve injury repair in ratsHeliyon9e14626

[103] [103] Hibbitts A Jet al2022 Multi-factorial nerve guidance conduit engineering improves outcomes in inflammation, angiogenesis and large defect nerve repairMatrix Biol.10634–57

[104] [104] Huang C W, Hsueh Y Y, Huang W C, Patel S and Li S 2019 Multipotent vascular stem cells contribute to neurovascular regeneration of peripheral nerveStem. Cell Res. Ther.10234

[105] [105] Simeoli Ret al2017 Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve traumaNat. Commun.81778

[106] [106] Sugiaman V K, Djuanda R, Pranata N, Naliani S, Demolsky W L and Jeffrey 2022 Tissue engineering with stem cell from human exfoliated deciduous teeth (SHED) and collagen matrix, regulated by growth factor in regenerating the dental pulpPolymers143712

[107] [107] Luo L Het al2020 Application of bioactive hydrogels combined with dental pulp stem cells for the repair of large gap peripheral nerve injuriesBioact. Mater.6638–54

[108] [108] Hann S Y, Cui H T, Esworthy T, Zhou X, Lee S J, Plesniak M W and Zhang L G 2021 Dual 3D printing for vascularized bone tissue regenerationActa Biomater.123263–74

[109] [109] Wu Y C, Zeng Y, Chen Y Z, Li C, Qiu R H and Liu W D 2021 Photocurable 3D printing of high toughness and self-healing hydrogels for customized wearable flexible sensorsAdv. Funct. Mater.312107202

[110] [110] Singh D, Harding A J, Albadawi E, Boissonade F M, Haycock J W and Claeyssens F 2018 Additive manufactured biodegradable poly (glycerol sebacate methacrylate) nerve guidance conduitsActa Biomater.7848–63

[111] [111] Singh A, Asikainen S, Teotia A K, Shiekh P A, Huotilainen E, Qayoom I, Partanen J, Seppl J and Kumar A 2018 Biomimetic photocurable three-dimensional printed nerve guidance channels with aligned cryomatrix lumen for peripheral nerve regenerationACS Appl. Mater. Interfaces1043327–42

[112] [112] Caprioli M, Roppolo I, Chiappone A, Larush L, Pirri C F and Magdassi S 2021 3D-printed self-healing hydrogels via Digital Light ProcessingNat. Commun.122462

[113] [113] Zhu H, Yao C, Wei B Y, Xu C, Huang X X, Liu Y, He J K, Zhang J N and Li D C 2023 3D printing of functional bioengineered constructs for neural regeneration: a reviewInt. J. Extrem. Manuf.5042004

[114] [114] Thompson J Ret al2019 Two-photon polymerized poly (caprolactone) retinal cell delivery scaffolds and their systemic and retinal biocompatibilityActa Biomater.94204–18

[115] [115] Gasparotti R, Padua L, Briani C and Lauria G 2017 New technologies for the assessment of neuropathiesNat. Rev. Neurol.13203–16

[116] [116] Ren J Y, Tang X D, Wang T, Wei X, Zhang J H, Lu L J, Liu Y and Yang B 2022 A dual-modal magnetic resonance/photoacoustic imaging tracer for long-term high-precision tracking and facilitating repair of peripheral nerve injuriesAdv. Healthcare Mater.112200183

[117] [117] Shuai C J, Shi X X, Yang F, Tian H F and Feng P 2024 Oxygen vacancy boosting Fenton reaction in bone scaffold towards fighting bacterial infectionInt. J. Extrem. Manuf.6015101

[118] [118] Yan D Xet al2022 Ultraflexible and stretchable intrafascicular peripheral nerve recording device with axon-dimension, cuff-less microneedle electrode arraySmall182200311

[119] [119] Yuan X, Yuan W H, Ding L, Shi M, Luo L, Wan Y, Oh J, Zhou Y F, Bian L M and Deng D Y B 2021 Cell-adaptable dynamic hydrogel reinforced with stem cells improves the functional repair of spinal cord injury by alleviating neuroinflammationBiomaterials279121190

[120] [120] Chen Y Wet al2024 3D printed grafts with gradient structures for organized vascular regenerationInt. J. Extrem. Manuf.6035503

[121] [121] Zhang D T, Li Z M, Shi H F, Yao Y J, Du W, Lu P, Liang K J, Hong L J and Gao C Y 2022 Micropatterns and peptide gradient on the inner surface of a guidance conduit synergistically promotes nerve regenerationin vivo Bioact. Mater.9134–46

[122] [122] Guo X, Wang X F, Li X Y, Jiang Y C, Han S S, Ma L, Guo H Y, Wang Z X and Li Q 2020 Endothelial cell migration on poly (-caprolactone) nanofibers coated with a nanohybrid shish-kebab structure mimicking collagen fibrilsBiomacromolecules211202–13

[123] [123] Zhao Q L, Wang J, Wang Y L, Cui H Q and Du X M 2020 A stage-specific cell-manipulation platform for inducing endothelialization on demandNatl Sci. Rev.7629–43

[124] [124] Nie Jet al2018 Vessel-on-a-chip with hydrogel-based microfluidicsSmall141802368

[125] [125] Osaki T, Sivathanu V and Kamm R D 2018 Engineered 3D vascular and neuronal networks in a microfluidic platformSci. Rep.85168

[126] [126] Zhou D Z, Dou B H, Kroh F, Wang C Q and Ouyang L L 2023 Biofabrication strategies with single-cell resolution: a reviewInt. J. Extrem. Manuf.5042005

[127] [127] Lyu Z L, Park J, Kim K M, Jin H J, Wu H D, Rajadas J, Kim D H, Steinberg G K and Lee W 2021 A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic strokeNat. Biomed. Eng.5847–63

[128] [128] Van Lent J, Vendredy L, Adriaenssens E, Da Silva Authier T, Asselbergh B, Kaji M, Weckhuysen S, Van Den Bosch L, Baets J and Timmerman V 2023 Downregulation of PMP22 ameliorates myelin defects in iPSC-derived human organoid cultures of CMT1ABrain1462885–96

[129] [129] Mansour A A, Gonalves J T, Bloyd C W, Li H, Fernandes S, Quang D, Johnston S, Parylak S L, Jin X and Gage F H 2018 Anin vivomodel of functional and vascularized human brain organoidsNat. Biotechnol.36432–41

[130] [130] Moccia Set al2018 Toward improving safety in neurosurgery with an active handheld instrumentAnn. Biomed. Eng.461450–64

[131] [131] Chen Y Q, Tao J W, Li L, Mao J B, Zhu C T, Lao J M, Yang Y and Shen L J 2017 Feasibility study on robot-assisted retinal vascular bypass surgery in anex vivoporcine modelActa Ophthalmol.95e462–7

[132] [132] Xie M J, Shi Y, Zhang C, Ge M J, Zhang J B, Chen Z C, Fu J Z, Xie Z J and He Y 2022 In situ 3D bioprinting with bioconcrete bioinkNat. Commun.133597

[133] [133] Wang Y X, Pereira R F, Peach C, Huang B Y, Vyas C and Bartolo P 2023 Roboticin situbioprinting for cartilage tissue engineeringInt. J. Extrem. Manuf.5032004

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Zhan Ning, Li Shuangyang, Liu Zhichao, Zhang Jingyu, Zhang Xiaoting, Peng Lianjie, Tian Lixin, Lin Lining, Qiu Tao, Luo Yaxian, He Yong, Sun Mouyuan, Yu Mengfei, Wang Huiming. Neurovascularization strategy: pathfinder and interlocutor for peripheral nerve tissue engineering in a sequential process[J]. International Journal of Extreme Manufacturing, 2025, 7(2): 22006

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Received: May. 8, 2024

Accepted: May. 29, 2025

Published Online: May. 29, 2025

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DOI:10.1088/2631-7990/ad92c8

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