Acta Laser Biology Sinica, Volume. 32, Issue 4, 360(2023)

Effect of Anlotinib on Proliferation and Apoptosis of Lung Cancer cell A549 and Regulation of PI3K/AKT Pathway

DENG Shuangnian1, LI Juan2, and LI Hui3
Author Affiliations
  • 1[in Chinese]
  • 2[in Chinese]
  • 3[in Chinese]
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    References(12)

    [2] [2] HOY H, LYNCH T, BECK M. Surgical treatment of lung cancer[J] Critical Care Nursing Clinics North America, 2019, 31(3): 303-313..

    [4] [4] SYED Y Y. Anlotinib: first global approval[J] . Drugs, 2018, 78(10): 1057-1062.

    [5] [5] SHEN G, ZHENG F, REN D, et al. Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development[J] . Journal of Hematology & Oncology, 2018, 11(1): 120.

    [6] [6] BABINA I S, TURNER N C. Advances and challenges in target-ing FGFR signalling in cancer[J] . Nature Reviews Cancer, 2017, 17(5): 318-332.

    [7] [7] SZTURZ P, RAYMOND E, ABITBOL C, et al. Understanding c-MET signalling in squamous cell carcinoma of the head & neck[J] . Criti-cal Reviews in Oncology Hematology, 2017, 111: 39-51.

    [8] [8] HOXHAJ G, MANNING B D. The PI3K-AKT network at the in-terface of oncogenic signalling and cancer metabolism[J] . Nature Reviews Cancer, 2020, 20(2): 74-88.

    [9] [9] TAN A C. Targeting the PI3K/Akt/mTOR pathway in non-small cell lung cancer (NSCLC)[J] . Thorac Cancer, 2020, 11(3): 511-518.

    [11] [11] ARENA S, SALATI M, SORGENTONI G, et al. Characterization of tumor-derived mesenchymal stem cells potentially differentiat-ing into cancer-associated fibroblasts in lung cancer[J] . Clinical & Translational Oncology, 2018, 20(12): 1582-1591.

    [14] [14] XIE C, WAN X, QUAN H, et al. Preclinical characterization of anlotinib, a highly potent and selective vascular endothelial growth factor receptor-2 inhibitor[J] . Cancer Science, 2018, 109(4): 1207-1219.

    [15] [15] HE C, WU T, HAO Y. Anlotinib induces hepatocellular carcinoma apoptosis and inhibits proliferation via Erk and Akt pathway[J] . Biochemical and Biophysical Research Commun, 2018, 503(4): 3093-3099.

    [18] [18] YANG Y, GAO M, LIN Z, et al. DEK promoted EMT and angiogenesis through regulating PI3K/AKT/mTOR pathway in triple-negative breast cancer[J] . Oncotarget, 2017, 8(58): 98708-98722.

    [19] [19] RADEMACHER B L, MATKOWSKYJ K A, LACOUNT E D, et al. Topical application of a dual PI3K/mTOR inhibitor prevents anal carcinogenesis in a human papillomavirus mouse model of anal cancer[J] . European Journal of Cancer Prevention, 2019, 28(6): 483-491.

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    DENG Shuangnian, LI Juan, LI Hui. Effect of Anlotinib on Proliferation and Apoptosis of Lung Cancer cell A549 and Regulation of PI3K/AKT Pathway[J]. Acta Laser Biology Sinica, 2023, 32(4): 360

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    Paper Information

    Received: Mar. 11, 2023

    Accepted: --

    Published Online: Jan. 26, 2024

    The Author Email:

    DOI:10.3969/j.issn.1007-7146.2023.04.009

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