Advances in Applications of Plasmonics in Biomedical Field (Invited)

Yu Lu; Qifan Zhou; Ao Li; Xiangwei Zhao

doi:10.3788/AOSOL250430

Acta Optica Sinica (Online), Volume. 2, Issue 7, 0716001(2025)

Advances in Applications of Plasmonics in Biomedical Field (Invited)

Yu Lu, Qifan Zhou, Ao Li, and Xiangwei Zhao^*

State Key Laboratory of Digital Medical Engineering, School of Biological Science & Medical Engineering, Southeast University, Nanjing 211189, Jiangsu , China

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References(128)

[1] Ritchie R H. Plasma losses by fast electrons in thin films[J]. Physical Review, 106, 874-881(1957).

[2] Kale M J, Avanesian T, Christopher P. Direct photocatalysis by plasmonic nanostructures[J]. ACS Catalysis, 4, 116-128(2014).

[3] Brongersma M L, Halas N J, Nordlander P. Plasmon-induced hot carrier science and technology[J]. Nature Nanotechnology, 10, 25-34(2015).

[4] Besteiro L V, Kong X T, Wang Z M et al. Understanding hot-electron generation and plasmon relaxation in metal nanocrystals: quantum and classical mechanisms[J]. ACS Photonics, 4, 2759-2781(2017).

[5] Kim M, Lee J H, Nam J M. Plasmonic photothermal nanoparticles for biomedical applications[J]. Advanced Science, 6, 1900471(2019).

[6] Ma X Y, Sim S J. Single plasmonic nanostructures for biomedical diagnosis[J]. Journal of Materials Chemistry B, 8, 6197-6216(2020).

[7] Xin H B, Namgung B, Lee L P. Nanoplasmonic optical antennas for life sciences and medicine[J]. Nature Reviews Materials, 3, 228-243(2018).

[8] Ni Y, Kan C X, Xu J et al. The synthesis of high yield Au nanoplate and optimized optical properties[J]. Superlattices and Microstructures, 114, 124-142(2018).

[9] Barnes W L, Dereux A, Ebbesen T W. Surface plasmon subwavelength optics[J]. Nature, 424, 824-830(2003).

[10] Delga A, Feist J, Bravo-Abad J et al. Quantum emitters near a metal nanoparticle: strong coupling and quenching[J]. Physical Review Letters, 112, 253601(2014).

[11] Shrivastav A M, Cvelbar U, Abdulhalim I. A comprehensive review on plasmonic-based biosensors used in viral diagnostics[J]. Communications Biology, 4, 70(2021).

[12] Harpaz D, Koh B, Seet R C S et al. Functionalized silicon dioxide self-referenced plasmonic chip as point-of-care biosensor for stroke biomarkers NT-proBNP and S100β[J]. Talanta, 212, 120792(2020).

[13] Wang Q, Ren Z H, Zhao W M et al. Research advances on surface plasmon resonance biosensors[J]. Nanoscale, 14, 564-591(2022).

[14] Blasi D, Sarcina L, Tricase A et al. Enhancing the sensitivity of biotinylated surfaces by tailoring the design of the mixed self-assembled monolayer synthesis[J]. ACS Omega, 5, 16762-16771(2020).

[15] Sinha R K. Wavelength modulation based surface plasmon resonance sensor for detection of cardiac marker proteins troponin I and troponin T[J]. Sensors and Actuators A, 332, 113104(2021).

[16] Su H, Li S P, Kerman K. Novel thiolated-PEG linker molecule for biosensor development on gold surfaces[J]. Biosensors and Bioelectronics, 141, 111477(2019).

[17] Zhou Z Y, Yang Z, Xia L et al. Construction of an enzyme-based all-fiber SPR biosensor for detection of enantiomers[J]. Biosensors and Bioelectronics, 198, 113836(2022).

[18] Li R, Zhao Y, Fan H L et al. Metasurface-driven and nanomaterial-coupled plasmonic biosensor for the rapid and quantitative clinical identification of neutralizing antibodies against SARS-CoV-2 variants[J]. Advanced Functional Materials, 33, 2306145(2023).

[19] Chen Y Q, Zhang H Z, Li R et al. Novel multifunctional meta-surface plasmon resonance chip microplate for high-throughput molecular screening[J]. Advanced Healthcare Materials, 13, 2401097(2024).

[20] Zhu J F, Wang Z Y, Lin S W et al. Low-cost flexible plasmonic nanobump metasurfaces for label-free sensing of serum tumor marker[J]. Biosensors and Bioelectronics, 150, 111905(2020).

[21] Li Q, Wang Q, Yang X H et al. High sensitivity surface plasmon resonance biosensor for detection of microRNA and small molecule based on graphene oxide-gold nanoparticles composites[J]. Talanta, 174, 521-526(2017).

[22] Wang Y Y, Hu Y R, Xie R B et al. Ultrasensitive label-free miRNA-21 detection based on MXene-enhanced plasmonic lateral displacement measurement[J]. Nanophotonics, 12, 4055-4062(2023).

[23] Wang Y D, Mao Z H, Chen Q et al. Rapid and sensitive detection of PD-L1 exosomes using Cu-TCPP 2D MOF as a SPR sensitizer[J]. Biosensors and Bioelectronics, 201, 113954(2022).

[24] Wang R, Liu C L, Wei Y et al. Fiber SPR biosensor sensitized by MOFs for MUC1 protein detection[J]. Talanta, 258, 124467(2023).

[25] Dolci M, Bryche J F, Leuvrey C et al. Robust clicked assembly based on iron oxide nanoparticles for a new type of SPR biosensor[J]. Journal of Materials Chemistry C, 6, 9102-9110(2018).

[26] Yoo H, Shin J, Sim J et al. Reusable surface plasmon resonance biosensor chip for the detection of H1N1 influenza virus[J]. Biosensors and Bioelectronics, 168, 112561(2020).

[27] Zu L J, Wang X C, Liu P et al. Ultrasensitive and multiple biomarker discrimination for Alzheimer’s disease via plasmonic & microfluidic sensing technologies[J]. Advanced Science, 11, 2470138(2024).

[28] Topor C V, Puiu M, Bala C. Strategies for surface design in surface plasmon resonance (SPR) sensing[J]. Biosensors, 13, 465(2023).

[29] D’Agata R, Bellassai N, Spoto G. Exploiting the design of surface plasmon resonance interfaces for better diagnostics: a perspective review[J]. Talanta, 266, 125033(2024).

[30] Xu D D, Deng Y L, Li C Y et al. Metal-enhanced fluorescent dye-doped silica nanoparticles and magnetic separation: a sensitive platform for one-step fluorescence detection of prostate specific antigen[J]. Biosensors and Bioelectronics, 87, 881-887(2017).

[31] Luan J Y, Seth A, Gupta R et al. Ultrabright fluorescent nanoscale labels for the femtomolar detection of analytes with standard bioassays[J]. Nature Biomedical Engineering, 4, 518-530(2020).

[32] Song H Y, Wong T I, Guo S F et al. Nanoimprinted thrombin aptasensor with picomolar sensitivity based on plasmon excited quantum dots[J]. Sensors and Actuators B, 221, 207-216(2015).

[33] Ali Badshah M, Ju J, Lu X et al. Enhancing the sensitivity of DNA microarrays by metal-enhanced fluorescence using vertical nanorod structures[J]. Sensors and Actuators B, 274, 451-457(2018).

[34] Song H Y, Wong T I, Sadovoy A et al. Imprinted gold 2D nanoarray for highly sensitive and convenient PSA detection via plasmon excited quantum dots[J]. Lab on a Chip, 15, 253-263(2015).

[35] Lin C W, Huang S N, Colangelo M et al. Surface plasmon enhanced upconversion fluorescence in short-wave infrared for in vivo imaging of ovarian cancer[J]. ACS Nano, 16, 12930-12940(2022).

[36] Trofymchuk K, Glembockyte V, Grabenhorst L et al. Addressable nanoantennas with cleared hotspots for single-molecule detection on a portable smartphone microscope[J]. Nature Communications, 12, 950(2021).

[37] Cruz D F, Fontes C M, Semeniak D et al. Ultrabright fluorescence readout of an inkjet-printed immunoassay using plasmonic nanogap cavities[J]. Nano Letters, 20, 4330-4336(2020).

[38] Semeniak D, Cruz D F, Chilkoti A et al. Plasmonic fluorescence enhancement in diagnostics for clinical tests at point-of-care: a review of recent technologies[J]. Advanced Materials, 35, 2107986(2023).

[39] Seiça A F S, Iqbal M H, Carvalho A et al. Study of membrane protein monolayers using surface-enhanced infrared absorption spectroscopy (SEIRAS): critical dependence of nanostructured gold surface morphology[J]. ACS Sensors, 6, 2875-2882(2021).

[40] Hui X D, Yang C, Li D X et al. Infrared plasmonic biosensor with tetrahedral DNA nanostructure as carriers for label-free and ultrasensitive detection of miR-155[J]. Advanced Science, 8, 2100583(2021).

[41] Yilmaz H, Mohapatra S S, Culha M. Surface-enhanced infrared absorption spectroscopy for microorganisms discrimination on silver nanoparticle substrates[J]. Spectrochimica Acta Part A, 268, 120699(2022).

[42] Li D X, Zhou H, Hui X D et al. Plasmonic biosensor augmented by a genetic algorithm for ultra-rapid, label-free, and multi-functional detection of COVID-19[J]. Analytical Chemistry, 93, 9437-9444(2021).

[43] Yao Z Q, Zhang Q D, Zhu W T et al. Rapid detection of SARS-CoV-2 viral nucleic acids based on surface enhanced infrared absorption spectroscopy[J]. Nanoscale, 13, 10133-10142(2021).

[44] Li Z Y, Zhu Y B, Hao Y F et al. Hybrid metasurface-based mid-infrared biosensor for simultaneous quantification and identification of monolayer protein[J]. ACS Photonics, 6, 501-509(2019).

[45] Zhou H, Hui X D, Li D X et al. Metal-organic framework-surface-enhanced infrared absorption platform enables simultaneous on-chip sensing of greenhouse gases[J]. Advanced Science, 7, 2001173(2020).

[46] Wu C C, Guo X D, Duan Y et al. Ultrasensitive mid-infrared biosensing in aqueous solutions with graphene plasmons[J]. Advanced Materials, 34, 2110525(2022).

[47] Kozuch J, Ataka K, Heberle J. Surface-enhanced infrared absorption spectroscopy[J]. Nature Reviews Methods Primers, 3, 70(2023).

[48] Wang J K, Xie Z L, Zhu Y L et al. Surface-enhanced infrared absorption spectroscopy (SEIRAS) for biochemical analysis: progress and perspective[J]. Trends in Environmental Analytical Chemistry, 41, e00226(2024).

[49] Lin J S, Tian X D, Li G et al. Advanced plasmonic technologies for multi-scale biomedical imaging[J]. Chemical Society Reviews, 51, 9445-9468(2022).

[50] Wang W J, Li Y, Nie A X et al. A portable SERS reader coupled with catalytic hairpin assembly for sensitive microRNA-21 lateral flow sensing[J]. Analyst, 146, 848-854(2021).

[51] Villa J E L, Garcia I, Jimenez de Aberasturi D et al. SERS-based immunoassay for monitoring cortisol-related disorders[J]. Biosensors and Bioelectronics, 165, 112418(2020).

[52] Qiao X Z, Su B S, Liu C et al. Selective surface enhanced Raman scattering for quantitative detection of lung cancer biomarkers in superparticle@MOF structure[J]. Advanced Materials, 30, 1702275(2018).

[53] Zhang Q, Ma R F, Zhang Y Z et al. Dual-aptamer-assisted ratiometric SERS biosensor for ultrasensitive and precise identification of breast cancer exosomes[J]. ACS Sensors, 8, 875-883(2023).

[54] Zhang D, Huang L, Liu B et al. Quantitative and ultrasensitive detection of multiplex cardiac biomarkers in lateral flow assay with core-shell SERS nanotags[J]. Biosensors and Bioelectronics, 106, 204-211(2018).

[55] Chen R P, Du X, Cui Y J et al. Vertical flow assay for inflammatory biomarkers based on nanofluidic channel array and SERS nanotags[J]. Small, 16, 2002801(2020).

[56] Wang J, Wuethrich A, Sina A A et al. Tracking extracellular vesicle phenotypic changes enables treatment monitoring in melanoma[J]. Science Advances, 6, eaax3223(2020).

[57] Lin W M, Yuan L W, Gao Z H et al. An integrated sample-to-answer SERS platform for multiplex phenotyping of extracellular vesicles[J]. Sensors and Actuators B, 394, 134355(2023).

[58] Xiao J Y, Chen Y X, Xu T L et al. Hand-held Raman spectrometer-based flexible plasmonic biosensor for label-free multiplex urinalysis[J]. Talanta, 266, 124966(2024).

[59] Cialla-May D, Bonifacio A, Bocklitz T et al. Biomedical SERS: the current state and future trends[J]. Chemical Society Reviews, 53, 8957-8979(2024).

[60] Dieringer J A, Lettan R B, Scheidt K A et al. A frequency domain existence proof of single-molecule surface-enhanced Raman spectroscopy[J]. Journal of the American Chemical Society, 129, 16249-16256(2007).

[61] Xu H X, Bjerneld E J, Käll M et al. Spectroscopy of single hemoglobin molecules by surface enhanced Raman scattering[J]. Physical Review Letters, 83, 4357-4360(1999).

[62] Zhao Q, Hilal H, Kim J et al. All-hot-spot bulk surface-enhanced Raman scattering (SERS) substrates: attomolar detection of adsorbates with designer plasmonic nanoparticles[J]. Journal of the American Chemical Society, 144, 13285-13293(2022).

[63] Fang W N, Jia S S, Chao J et al. Quantizing single-molecule surface-enhanced Raman scattering with DNA origami metamolecules[J]. Science Advances, 5, eaau4506(2019).

[64] Tapio K, Mostafa A, Kanehira Y et al. A versatile DNA origami-based plasmonic nanoantenna for label-free single-molecule surface-enhanced Raman spectroscopy[J]. ACS Nano, 15, 7065-7077(2021).

[65] Schuknecht F, Kołątaj K, Steinberger M et al. Accessible hotspots for single-protein SERS in DNA-origami assembled gold nanorod dimers with tip-to-tip alignment[J]. Nature Communications, 14, 7192(2023).

[66] Niu R J, Gao F, Wang D et al. Pattern recognition directed assembly of plasmonic gap nanostructures for single-molecule SERS[J]. ACS Nano, 16, 14622-14631(2022).

[67] Wang R Y, Ma J L, Dai X et al. Highly active SERS chip with both structure-ameliorated chemical enhancement and nanocavity-mediated electromagnetic enhancement[J]. Sensors and Actuators B, 374, 132782(2023).

[68] Demirel G, Gieseking R L M, Ozdemir R et al. Molecular engineering of organic semiconductors enables noble metal-comparable SERS enhancement and sensitivity[J]. Nature Communications, 10, 5502(2019).

[69] Sun H Z, Gong W B, Cong S et al. Ultrathin two-dimensional metal-organic framework nanosheets with activated ligand-cluster units for enhanced SERS[J]. ACS Applied Materials & Interfaces, 14, 2326-2334(2022).

[70] de Albuquerque C D L, Sobral-Filho R G, Poppi R J et al. Digital protocol for chemical analysis at ultralow concentrations by surface-enhanced Raman scattering[J]. Analytical Chemistry, 90, 1248-1254(2018).

[71] Nam W, Kim W, Zhou W et al. A digital SERS sensing platform using 3D nanolaminate plasmonic crystals coupled with Au nanoparticles for accurate quantitative detection of dopamine[J]. Nanoscale, 13, 17340-17349(2021).

[72] Yan Z B, Dutta S, Liu Z R et al. A label-free platform for identification of exosomes from different sources[J]. ACS Sensors, 4, 488-497(2019).

[73] Kim J Y, Koh E H, Yang J Y et al. 3D plasmonic gold nanopocket structure for SERS machine learning-based microplastic detection[J]. Advanced Functional Materials, 34, 2307584(2024).

[74] Bi X Y, Czajkowsky D M, Shao Z F et al. Digital colloid-enhanced Raman spectroscopy by single-molecule counting[J]. Nature, 628, 771-775(2024).

[75] Li J R, Wuethrich A, Sina A A I et al. A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy[J]. Nature Communications, 12, 1087(2021).

[76] Li J R, Sina A A I, Antaw F et al. Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions[J]. Advanced Science, 10, 2204207(2023).

[77] Li A, Mo X F, Lu Y et al. Digital SERS immunoassay of Interleukin-6 based on Au@Ag-Au nanotags[J]. Biosensors and Bioelectronics, 270, 116973(2025).

[78] Azzam S I, Kildishev A V, Ma R M et al. Ten years of spasers and plasmonic nanolasers[J]. Light: Science & Applications, 9, 90(2020).

[79] Stockman M I. Brief history of spaser from conception to the future[J]. Advanced Photonics, 2, 054002(2020).

[80] Yang A K, Hoang T B, Dridi M et al. Real-time tunable lasing from plasmonic nanocavity arrays[J]. Nature Communications, 6, 6939(2015).

[81] Galanzha E I, Weingold R, Nedosekin D A et al. Spaser as a biological probe[J]. Nature Communications, 8, 15528(2017).

[82] Cho S, Martino N, Yun S H. Half-wave nanolasers and intracellular plasmonic lasing particles[J/OL]. Nature Nanotechnology, 1-7. https://www.nature.com/articles/s41565-024-01843-7

[83] Xin H B, Sim W J, Namgung B et al. Quantum biological tunnel junction for electron transfer imaging in live cells[J]. Nature Communications, 10, 3245(2019).

[84] Lu D Y, Zhu G S, Li X et al. Dynamic monitoring of oscillatory enzyme activity of individual live bacteria via nanoplasmonic optical antennas[J]. Nature Photonics, 17, 904-911(2023).

[85] Afzalinia A, Mirzaee M. Ultrasensitive fluorescent miRNA biosensor based on a “sandwich” oligonucleotide hybridization and fluorescence resonance energy transfer process using an ln(Ⅲ)-MOF and Ag nanoparticles for early cancer diagnosis: application of central composite design[J]. ACS Applied Materials & Interfaces, 12, 16076-16087(2020).

[86] Li H, Wang M, Wang C Z et al. Silver nanoparticle-enhanced fluorescence resonance energy transfer sensor for human platelet-derived growth factor-BB detection[J]. Analytical Chemistry, 85, 4492-4499(2013).

[87] Qin Z P, Chan W C W, Boulware D R et al. Significantly improved analytical sensitivity of lateral flow immunoassays by using thermal contrast[J]. Angewandte Chemie International Edition, 51, 4358-4361(2012).

[88] Trakoolwilaiwan T, Takeuchi Y, Leung T S et al. Development of a thermochromic lateral flow assay to improve sensitivity for dengue virus serotype 2 NS1 detection[J]. Nanoscale, 15, 12915-12925(2023).

[89] Zhao Y F, Huang Y, Zhao X W et al. Nanoparticle-based photoacoustic analysis for highly sensitive lateral flow assays[J]. Nanoscale, 8, 19204-19210(2016).

[90] Zhao Y F, Cao M F, McClelland J F et al. A photoacoustic immunoassay for biomarker detection[J]. Biosensors and Bioelectronics, 85, 261-266(2016).

[91] Almassian D R, Cockrell L M, Nelson W M. Portable nucleic acid thermocyclers[J]. Chemical Society Reviews, 42, 8769-8798(2013).

[92] Richardson H H, Carlson M T, Tandler P J et al. Experimental and theoretical studies of light-to-heat conversion and collective heating effects in metal nanoparticle solutions[J]. Nano Letters, 9, 1139-1146(2009).

[93] Roche P J R, Beitel L K, Khan R et al. Demonstration of a plasmonic thermocycler for the amplification of human androgen receptor DNA[J]. Analyst, 137, 4475-4481(2012).

[94] Son J H, Cho B, Hong S et al. Ultrafast photonic PCR[J]. Light: Science & Applications, 4, e280(2015).

[95] Ahrberg C D, Choi J W, Lee J M et al. Plasmonic heating-based portable digital PCR system[J]. Lab on a Chip, 20, 3560-3568(2020).

[96] Huang X J, Zhang W L, Guan G Q et al. Design and functionalization of the NIR-responsive photothermal semiconductor nanomaterials for cancer theranostics[J]. Accounts of Chemical Research, 50, 2529-2538(2017).

[97] Zhou C Y, Zhang L, Sun T et al. Activatable NIR-II plasmonic nanotheranostics for efficient photoacoustic imaging and photothermal cancer therapy[J]. Advanced Materials, 33, 2006532(2021).

[98] Ye J M, Li Z, Fu Q R et al. Quantitative photoacoustic diagnosis and precise treatment of inflammation in vivo using activatable theranostic nanoprobe[J]. Advanced Functional Materials, 30, 2001771(2020).

[99] Riley R S, Day E S. Gold nanoparticle-mediated photothermal therapy: applications and opportunities for multimodal cancer treatment[J]. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 9, e1449(2017).

[100] Ali M R K, Wu Y, El-Sayed M A. Gold-nanoparticle-assisted plasmonic photothermal therapy advances toward clinical application[J]. The Journal of Physical Chemistry C, 123, 15375-15393(2019).

[101] Chen Z G, Wang Q, Wang H L et al. Ultrathin PEGylated W18O49 nanowires as a new 980 nm-laser-driven photothermal agent for efficient ablation of cancer cells in vivo[J]. Advanced Materials, 25, 2095-2100(2013).

[102] Song G S, Shen J, Jiang F R et al. Hydrophilic molybdenum oxide nanomaterials with controlled morphology and strong plasmonic absorption for photothermal ablation of cancer cells[J]. ACS Applied Materials & Interfaces, 6, 3915-3922(2014).

[103] Yu N, Hu Y, Wang X Y et al. Dynamically tuning near-infrared-induced photothermal performances of TiO2 nanocrystals by Nb doping for imaging-guided photothermal therapy of tumors[J]. Nanoscale, 9, 9148-9159(2017).

[104] Kriegel I, Jiang C Y, Rodríguez-Fernández J et al. Tuning the excitonic and plasmonic properties of copper chalcogenide nanocrystals[J]. Journal of the American Chemical Society, 134, 1583-1590(2012).

[105] Dorfs D, Härtling T, Miszta K et al. Reversible tunability of the near-infrared valence band plasmon resonance in Cu(2-x)Se nanocrystals[J]. Journal of the American Chemical Society, 133, 11175-11180(2011).

[106] Balitskii O A, Sytnyk M, Stangl J et al. Tuning the localized surface plasmon resonance in Cu2-xSe nanocrystals by postsynthetic ligand exchange[J]. ACS Applied Materials & Interfaces, 6, 17770-17775(2014).

[107] Hsu S W, On K, Tao A R. Localized surface plasmon resonances of anisotropic semiconductor nanocrystals[J]. Journal of the American Chemical Society, 133, 19072-19075(2011).

[108] Chen Q, Zheng Z L, He X J et al. A tumor-targeted theranostic nanomedicine with strong absorption in the NIR-II biowindow for image-guided multi-gradient therapy[J]. Journal of Materials Chemistry B, 8, 9492-9501(2020).

[109] Moore C, Jokerst J V. Strategies for image-guided therapy, surgery, and drug delivery using photoacoustic imaging[J]. Theranostics, 9, 1550-1571(2019).

[110] Liu Y, Duan X D, Huang Y et al. Two-dimensional transistors beyond graphene and TMDCs[J]. Chemical Society Reviews, 47, 6388-6409(2018).

[111] Chen Y S, Frey W, Aglyamov S et al. Environment-dependent generation of photoacoustic waves from plasmonic nanoparticles[J]. Small, 8, 47-52(2012).

[112] Wang L V, Hu S. Photoacoustic tomography: in vivo imaging from organelles to organs[J]. Science, 335, 1458-1462(2012).

[113] Yim W, Zhou J J, Mantri Y et al. Gold nanorod-melanin hybrids for enhanced and prolonged photoacoustic imaging in the near-infrared-II window[J]. ACS Applied Materials & Interfaces, 13, 14974-14984(2021).

[114] Yan H X, Chen J Q, Li Y et al. Ultrasmall hybrid protein-copper sulfide nanoparticles for targeted photoacoustic imaging of orthotopic hepatocellular carcinoma with a high signal-to-noise ratio[J]. Biomaterials Science, 7, 92-103(2019).

[115] Ku G, Zhou M, Song S L et al. Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging at 1064 nm[J]. ACS Nano, 6, 7489-7496(2012).

[116] Bradac C. Nanoscale optical trapping: a review[J]. Advanced Optical Materials, 6, 1800005(2018).

[117] Zhang J C, Lu F F, Zhang W D et al. Optical trapping of single nano-size particles using a plasmonic nanocavity[J]. Journal of Physics: Condensed Matter, 32, 475301(2020).

[118] Crozier K B. Quo vadis, plasmonic optical tweezers?[J]. Light: Science & Applications, 8, 35(2019).

[119] Samadi M, Alibeigloo P, Aqhili A et al. Plasmonic tweezers: towards nanoscale manipulation[J]. Optics and Lasers in Engineering, 154, 107001(2022).

[120] Ozbay E. Plasmonics: merging photonics and electronics at nanoscale dimensions[J]. Science, 311, 189-193(2006).

[121] Berthelot J, Aćimović S S, Juan M L et al. Three-dimensional manipulation with scanning near-field optical nanotweezers[J]. Nature Nanotechnology, 9, 295-299(2014).

[122] Kang Z W, Chen J J, Wu S Y et al. Trapping and assembling of particles and live cells on large-scale random gold nano-island substrates[J]. Scientific Reports, 5, 9978(2015).

[123] Lee S Y, Kim H M, Park J et al. Enhanced plasmonic particle trapping using a hybrid structure of nanoparticles and nanorods[J]. ACS Applied Materials & Interfaces, 10, 41655-41663(2018).

[124] Hill E H, Li J G, Lin L H et al. Opto-thermophoretic attraction, trapping, and dynamic manipulation of lipid vesicles[J]. Langmuir, 34, 13252-13262(2018).

[125] Kang S Y, Nisar M S, Lu Y et al. A 3D biocompatible plasmonic tweezer for single cell manipulation[J]. Small Methods, 7, 2201379(2023).

[126] Fu W H, Chi H Y, Dai X et al. Efficient optical plasmonic tweezer-controlled single-molecule SERS characterization of pH-dependent amylin species in aqueous milieus[J]. Nature Communications, 14, 6996(2023).

[127] Shoji T, Itoh K, Saitoh J et al. Plasmonic manipulation of DNA using a combination of optical and thermophoretic forces: separation of different-sized DNA from mixture solution[J]. Scientific Reports, 10, 3349(2020).

[128] Zhao X T, Shi Y, Pan T et al. In situ single-cell surgery and intracellular organelle manipulation via thermoplasmonics combined optical trapping[J]. Nano Letters, 22, 402-410(2022).

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Yu Lu, Qifan Zhou, Ao Li, Xiangwei Zhao. Advances in Applications of Plasmonics in Biomedical Field (Invited)[J]. Acta Optica Sinica (Online), 2025, 2(7): 0716001

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Paper Information

Category: Biological, Medical Optics and Photonics

Received: Jan. 9, 2025

Accepted: Feb. 17, 2025

Published Online: Apr. 1, 2025

The Author Email: Xiangwei Zhao (xwzhao@seu.edu.cn)

DOI:10.3788/AOSOL250430

CSTR:32394.14.AOSOL250430

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology