NUCLEAR TECHNIQUES, Volume. 47, Issue 10, 100301(2024)
Synthesis and preliminary biological evaluation of a novel PET tracer for α-synuclein PET imaging
Figures & Tables(6)
Fig. 2. (a) HPLC radiochromatogram of 18/19F-YM, (b) HPLC radiochromatogram of 18F-YM in PBS and Serum at 37 ℃ for 2 h respectively
Fig. 3. (a) PET images of the whole body of mice at different time points after i.v. injection of 18F-YM, (b) Brain uptake -time curve of 18F-YM in mice at different time points after intravenous injection (color online)
Fig. 4. Major organ uptake-time curve of 18F-YM in mice at different time points after intravenous injection
Fig. 5. (a) Immunohistochemistry of main brain regions in C57BL/6J mice or A53T mice, (b) autoradiography of brain slices from A53T mice (color online)
Table 1. Biodistribution of radioactivity in normal C57BL/6J mice after 18F-YM injection (n=6)
View tableView in ArticleTable 1. Biodistribution of radioactivity in normal C57BL/6J mice after 18F-YM injection (n=6)
%ID/g 注射后时间Time after injection / min 组织Tissue 5 15 30 60 血Blood 3.19±0.37 1.62±0.27 0.77±0.08 0.35±0.11 脑Brain 2.34±0.41 1.96±0.18 0.82±0.02 0.42±0.03 心Heart 4.63±0.83 1.45±0.05 0.86±0.07 0.81±0.07 肝Liver 15.72±2.11 6.95±0.45 3.46±0.37 1.99±0.28 肾Kidney 12.16±2.76 4.80±0.52 2.83±0.58 1.40±0.17 肌肉Muscle 1.64±0.28 0.66±0.23 0.57±0.15 0.33±0.02
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Ce WANG, Donghui PAN, Siyi TAN, Lizhen WANG, Xinyu WANG, Junjie YAN, Chongyang CHEN, Yuping XU, Lianghua ZOU. Synthesis and preliminary biological evaluation of a novel PET tracer for α-synuclein PET imaging[J]. NUCLEAR TECHNIQUES, 2024, 47(10): 100301
Paper Information
Category: NUCLEAR CHEMISTRY, RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE
Received: Feb. 22, 2024
Accepted: --
Published Online: Dec. 13, 2024
The Author Email: XU Yuping (XUYuping), ZOU Lianghua (ZOULianghua)
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