Novel design of a NIR fiber optic probe for in situ detection of osteoarthritis

Fig. 2. （a）Schematic diagrams of the top end of the exit and entrance optical fibers，（b）the end face arrangement of 6 exit optical fibers，（c）the end face arrangement of 13 incident optical fibers

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Fig. 3. Setting photo of NIR fiber probe coupled with FTNIR system

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Fig. 4. (a) Conventional transmission FTNIR spectra and optical fiber - FTNIR spectra of sucrose powder, (b) optical fiber -FTNIR spectra of sucrose powder by 10-time repeated measurement at same position

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Fig. 5. Average in-situ NIR spectra of articular cartilage (Health and OA tissues) BC (a) and second derivative (2^nd-3-25SG) (b)

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Table 1. The simulation results of gradient-index (grin) lens with different distances to the top of fiber bundle

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Table 1. The simulation results of gradient-index (grin) lens with different distances to the top of fiber bundle

纤芯直径/mm	涂覆层直径/mm	光纤束与自聚焦透镜的距离/mm	6根出射光纤出射端的总能量/W
0.2	0.32	0	0.533
0.2	0.32	2	0.285
0.2	0.32	5	0.011
0.2	0.245	0	0.566
0.2	0.245	2	0.294
0.2	0.245	5	0.012
0.3	0.52	0	0.733
0.3	0.52	2	0.552
0.3	0.52	5	0.103

Table 2. The relationships between NIR spectral characteristic bands and main components, functional groups of articular cartilage ^[18]

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Table 2. The relationships between NIR spectral characteristic bands and main components, functional groups of articular cartilage ^[18]

主成分	波数/cm^-1	官能团
胶原蛋白胶原蛋白胶原蛋白	4 890 4 610 4 050	N-H面内弯曲振动 C-H反对称伸缩振动和变形振动蛋白分子的C-H组合和C-H-C对称伸缩震动的一级倍频
多糖	4 310	C-H伸缩振动和 CH₂ 变形振动
自由水	6 890	N-H、水伸缩振动的一级倍频和C=O伸缩振动的三级倍频
自由水和结合水	5 150	O-H的伸缩振动和变形震动

Table 3. FDA results of in-situ NIR spectra of healthy and OA tissues after 1^st -2-21SG pretreatment
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Table 3. FDA results of in-situ NIR spectra of healthy and OA tissues after 1^st -2-21SG pretreatment
类别判别结果识别率识别率（总）
健康 OA
初始案例健康 27 1 96.43% 97.62%
OA 1 55 98.21%
交叉验证健康 25 3 89.29% 90.47%
OA 5 51 91.07%
预测集健康 14 0 100% 96.43%
OA 1 13 92.86%

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Juan-Juan FU, Jin-Lan TANG, Yi-Lin BAO, Hui SHANG, Jin-Jin WU, Xiao WANG, Jian-Hua YIN. Novel design of a NIR fiber optic probe for in situ detection of osteoarthritis[J]. Journal of Infrared and Millimeter Waves, 2021, 40(6): 784

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Paper Information

Category: Research Articles

Received: Nov. 9, 2020

Accepted: --

Published Online: Feb. 16, 2022

The Author Email: Jian-Hua YIN (yin@nuaa.edu.cn)

DOI:10.11972/j.issn.1001-9014.2021.06.012

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology

Table 1. The simulation results of gradient-index (grin) lens with different distances to the top of fiber bundle

Table 1. The simulation results of gradient-index (grin) lens with different distances to the top of fiber bundle

Table 2. The relationships between NIR spectral characteristic bands and main components, functional groups of articular cartilage [18]

Table 2. The relationships between NIR spectral characteristic bands and main components, functional groups of articular cartilage [18]

Table 3. FDA results of in-situ NIR spectra of healthy and OA tissues after 1st -2-21SG pretreatment

Table 3. FDA results of in-situ NIR spectra of healthy and OA tissues after 1st -2-21SG pretreatment

Table 2. The relationships between NIR spectral characteristic bands and main components, functional groups of articular cartilage ^[18]

Table 2. The relationships between NIR spectral characteristic bands and main components, functional groups of articular cartilage ^[18]

Table 3. FDA results of in-situ NIR spectra of healthy and OA tissues after 1^st -2-21SG pretreatment

Table 3. FDA results of in-situ NIR spectra of healthy and OA tissues after 1^st -2-21SG pretreatment