Acta Laser Biology Sinica, Volume. 32, Issue 3, 272(2023)

Effects of Extract of Yacon on Nrf2/HO-1/NLRP3 Pathway on Acute Liver Injury in Rats

CHENG Shunzhi1, FENG Ling2, YANG Qi2, ZHANG Ziyu2, WU Zhengli2, and ZHANG Yongqina1
Author Affiliations
  • 1[in Chinese]
  • 2[in Chinese]
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    References(10)

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    [2] [2] MITCHELLR M, HARTUT J. Animal models of drug-induced liver injury[J] . Biochimica et Biophysica Acta-Molecular Basis of Disease, 2018, 1865(5): 1031-1039.

    [9] [9] XIANGFU J, YU L, DONGDONG F, et al. Caveolin-1 amelio-rates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/ NLRP3 pathway[J] . International Immunopharmacology, 2022, 114: 109558.

    [10] [10] YU L, ZIWEI G, JIAN L, et al. Insight into the regulation of NLRP3 inflammasome activation by mitochondria in liver injury and the protective role of natural products[J] . Pharmacotherapie, 2022, 156: 113968.

    [11] [11] ABDULLH A M, AFROZA A,SUKRIA H, et al. Role of NLRP3 inflammasome in liver disease[J] . Journal of Digestive Diseases, 2020, 21(8): 430-436.

    [12] [12] YANPING D, XIAOQING D, YIFAN M-A, et al. Astragaloside IV plays a role in reducing radiation-induced liver inflammation in mice by inhibiting thioredoxin-interacting protein/nod-like recep-tor protein 3 signaling pathway[J] . Journal of traditional Chinese Medicine, 2023,(1): 87-94.

    [22] [22] XIN Y, XINGKANG H, LINGYUN W, et al. Chlorogenic acid, the main antioxidant in coffee, reduces radiation-induced apoptosis and DNA damage via NF-E2-related factor 2 (Nrf2) activation in hepatocellular carcinoma[J] . Oxidative Medicine and Cellular Longevity, 2022, 2022: 4566949.

    [24] [24] FENG C, YINGXIA L, QIANHUI L, et al. Inhibition of hepatic NLRP3 inflammasome ameliorates non-alcoholic steatohepati-tis/hepatitis B-induced hepatic injury[J] . Clinics and Research in Hepatology and Gastroenterology, 2022, 47(1): 102056.

    [25] [25] FERNANDO L R, ALLEJANDRO P F, JOSE A P, et al. Emerging role of NLRP3 inflammasome and pyroptosis in liver transplan-tation[J] . International Journal of Molecular Sciences, 2022, 23(22): 14396.

    [27] [27] SHI A, SHI H, WANG Y, et al. Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury[J] . Int Immunopharmacol, 2018, 54: 125-130.

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    CHENG Shunzhi, FENG Ling, YANG Qi, ZHANG Ziyu, WU Zhengli, ZHANG Yongqina. Effects of Extract of Yacon on Nrf2/HO-1/NLRP3 Pathway on Acute Liver Injury in Rats[J]. Acta Laser Biology Sinica, 2023, 32(3): 272

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    Paper Information

    Received: Feb. 6, 2023

    Accepted: --

    Published Online: Jan. 17, 2024

    The Author Email:

    DOI:10.3969/j.issn.1007-7146.2023.03.010

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