Chinese Journal of Lasers, Volume. 45, Issue 12, 1207001(2018)

Large Field-of-View and Deep Tissue Optical Micro-Imaging Based on Parallel Wavefront Correction Algorithm

Qi Zhao1、*, Xin Shi1, Wei Gong2, Lejia Hu1, Yao Zheng1, Xinpei Zhu2, and Ke Si1,2、*
Author Affiliations
  • 1 State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China
  • 2 Center for Neuroscience, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
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    Figures & Tables(5)
    Schematic of conjugate adaptive optical correction system
    Schematic of parallel conjugate adaptive optical correction algorithm
    Phase residue distributions after the correction of different algorithms. (a) Conventional conjugate adaptive optical algorithm; (b) parallel conjugate adaptive optical algorithm
    Imaging results of fluorescent beads with diameter of 4 μm in 200 μm×200 μm field of view and luminous intensity profiles along white dotted lines 1, 2, and 3 after the correction of different algorithms. (a) Imaging result without scattering medium; (b) imaging result after random phase screen scattering; (c) imaging result after correction by conventional conjugate adaptive optical algorithm; (d) imaging result corrected by parallel conjugate adaptive optical algorithm; (e) luminous intensity
    Schematic of scattering medium configuration, imaging results of fluorescent beads with diameter of 4 μm in 200 μm×200 μm field of view, and luminous intensity profiles along white dotted lines after the correction of different algorithms. (a) Schematic of scattering medium configuration; (b) imaging result without scattering medium; (c) imaging result after mouse brain slice scattering; (d) imaging result corrected by conventional conjugate adaptive optical algorithm; (e) imaging result correct
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    Qi Zhao, Xin Shi, Wei Gong, Lejia Hu, Yao Zheng, Xinpei Zhu, Ke Si. Large Field-of-View and Deep Tissue Optical Micro-Imaging Based on Parallel Wavefront Correction Algorithm[J]. Chinese Journal of Lasers, 2018, 45(12): 1207001

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    Paper Information

    Category: biomedical photonics and laser medicine

    Received: Jul. 4, 2018

    Accepted: Aug. 5, 2018

    Published Online: May. 9, 2019

    The Author Email:

    DOI:10.3788/CJL201845.1207001

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