Nanopore technique is a label-free, high-throughput detection method at the single-molecule level. However, nanopore ionic current sensing, which reflects changes in ionic conductivity within the nanopore, serves as an indirect characterization method. This technique encounters significant challenges in distinguishing subtle differences between various molecules. The integrated nanopore electrochemistry-Raman spectroscopy technology could enable simultaneous electrochemical and spectral characterization of analytes. Therefore, this review systematically presents preparation methods of plasmonic nanopores for integrated nanopore electrochemistry-Raman spectroscopy technology and provides a route for optical-electrochemical nanopore measurement system. Emphasis will be put on the applications of single entity electrochemistry analysis, single nucleotide discrimination, and analysis of protein structure. Additionally, the challenges and development of integrated nanopore electrochemistry-Raman spectroscopy technology are discussed. Finally, we hope this review will provide a comprehensive overview of the integrated nanopore electrochemistry-Raman spectroscopy technology.