Chinese Journal of Lasers, Volume. 50, Issue 9, 0907105(2023)

High‑Accuracy Quantitative Functional Imaging Technique for Retinal Opto‑Physiology with Optical Coherence Tomography

Yanhong Ma and Pengfei Zhang*
Author Affiliations
  • School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian 116024, Liaoning, China
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    Figures & Tables(3)
    Visual fields of patients with retinopathy and structure of retina. (a) Visual manifestations of normal retina and three common blinding retinal diseases; (b) multilayered structure of retina[3]
    Expressions of function signals in human cone and mouse rod photoreceptors. (a) Optical stimulus-induced cone outer segment optical path length change and its projection on retina enface with stimulus pattern shown in lower left inset[50]; (b) square-shape stimulus-induced cone outer segment optical path length change and (c) temporal measurement results[50]; (d) dark-adapted mouse retina OCT image[51]; (e) changes of retinal contour in mice within 2 min after light stimulation[51]; (f) 3-5 times scattering enhancement in rod outer segments[51]; (g) scattering changes of Bruch’s membrane and sclera[51]; (h) ~2 μm position changes of external limiting membrane and inner/outer segment junction[51]
    Nanoscale visual photophysiological measurements of individual cone cells in human eye by AO-OCT[61]. (a) Detecting outer segment optical path length change (∆OPL) of dark-adapted cone cell stimulated with visible flash using phase information by AO-OCT; (b) en face intensity image of cone mosaic; (c) responses of cone cells to 637 nm visible light stimulus; (d) classifying cone cells into three types according to intensity of ∆OPL
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    Yanhong Ma, Pengfei Zhang. High‑Accuracy Quantitative Functional Imaging Technique for Retinal Opto‑Physiology with Optical Coherence Tomography[J]. Chinese Journal of Lasers, 2023, 50(9): 0907105

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    Paper Information

    Category: Biomedical Optical Imaging

    Received: Oct. 8, 2022

    Accepted: Nov. 25, 2022

    Published Online: Apr. 25, 2023

    The Author Email: Zhang Pengfei (pfzhang@dlut.edu.cn)

    DOI:10.3788/CJL221304

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