Fig. 1. Schematics of (a) principle of laser spot scanning confocal microscopy and (b) spot scanning process of confocal microscopy

Fig. 2. Spot scanning diagrams of objective pixel. (a) Fluorophore sparse area; (b) fluorophore dense area

Fig. 3. Process of feedback judgment in CLE-CM. (a) Fluorophore with extremely sparse density; (b) fluorophore with high density; (c) fluorophore with medium density

Fig. 4. Schematic of time subsection in upper threshold judgment

Fig. 5. (a) Pixel light-exposure time distribution; (b) real pixel value; (c) reconstructed image of CLE-CM

Fig. 6. Diagram of CLE-CM imaging system

Fig. 7. (a) Standard confocal contrast images; (b) distribution of pixel light-exposure time; (c) distribution of real pixel value; (d) reconstructed images of CLE-CM

Fig. 8. (a) Standard confocal images; (b) reconstructed images of CLE-CM

Fig. 9. Curves of fluorescence intensity