International Journal of Extreme Manufacturing, Volume. 7, Issue 2, 22001(2025)

Modular strategy with autologous bioreactor: a potential way for organ engineering

Bai Qingfeng, Tang Hai, Chen Yi, Pan Ziyin, Lin Weikang, Wang Lei, Hu Yulong, Xu Boyu, Yang Minglei, Zhao Guofang, Sun Weiyan, He Yong, and Chen Chang
References(175)

[1] [1] Elisseeff J, Badylak S F and Boeke J D 2021 Immune and genome engineering as the future of transplantable tissueNew Engl. J. Med.3852451–62

[2] [2] Ulasi I I and Ijoma C K 2016 Organ transplantation in NigeriaTransplantation100695–7

[3] [3] Giwa Set al2017 The promise of organ and tissue preservation to transform medicineNat. Biotechnol.35530–42

[4] [4] Xu K L, Han Y, Huang Y Y, Wei P, Yin J and Jiang J H 2022 The application of 3D bioprinting in urological diseasesMater. Today Bio16100388

[5] [5] Komae H, Ono M and Shimizu T 2018 Cell sheet-based vascularized myocardial tissue fabricationEur. Surg. Res.59276–85

[6] [6] Han J J 2023 Three-dimensional bioprinting of artificial organs: how close are we to its clinical application?Artif. Organs47912–3

[7] [7] Kim Y S and Mikos A G 2021 Emerging strategies in reprogramming and enhancing the fate of mesenchymal stem cells for bone and cartilage tissue engineeringJ. Control. Release330565–74

[8] [8] Luo Cet al2018 Anin vivocomparative study of the gelatin microtissue-based bottom-up strategy and top-down strategy in bone tissue engineering applicationJ. Biomed. Mater. Res.A107678–88

[9] [9] Wang X W, Wang Z, Zhai W Y, Wang F Y, Ge Z X, Yu H B and Yang W G 2021 Engineering biological tissues from the bottom-up: recent advances and future prospectsMicromachines1375

[10] [10] Kesireddy V and Kasper F K 2016 Approaches for building bioactive elements into synthetic scaffolds for bone tissue engineeringJ. Mater. Chem.B46773–86

[11] [11] Gu Q C, Sun L, Ji X Y, Wang H L, Yu J S and Zhou X G 2023 High-performance and high-precision Al2O3 architectures enabled by high-solid-loading, graphene-containing slurries for top-down DLP 3D printingJ. Eur. Ceram. Soc.43130–42

[12] [12] Peng X R, Kuang X, Roach D J, Wang Y Q, Hamel C M, Lu C L and Qi H J 2021 Integrating digital light processing with direct ink writing for hybrid 3D printing of functional structures and devicesAddit. Manuf.40101911

[13] [13] Santoliquido O, Colombo P and Ortona A 2019 Additive manufacturing of ceramic components by digital light processing: a comparison between the “bottom-up” and the “top-down” approachesJ. Eur. Ceram. Soc.392140–8

[14] [14] Schmidt T, Xiang Y, Bao X J and Sun T 2021 A paradigm shift in tissue engineering: from a top–down to a bottom–up strategyProcesses9935

[15] [15] Gauvin R, Chen Y C, Lee J W, Soman P, Zorlutuna P, Nichol J W, Bae H, Chen S C and Khademhosseini A 2012 Microfabrication of complex porous tissue engineering scaffolds using 3D projection stereolithographyBiomaterials333824–34

[16] [16] Mueller M, Rasoulinejad S, Garg S and Wegner S V 2020 The importance of cell–cell interaction dynamics in bottom-up tissue engineering: concepts of colloidal self-assembly in the fabrication of multicellular architecturesNano Lett.202257–63

[17] [17] Nichol J W and Khademhosseini A 2009 Modular tissue engineering: engineering biological tissues from the bottom upSoft Matter51312–9

[18] [18] Skylar-Scott M A, Uzel S G M, Nam L L, Ahrens J H, Truby R L, Damaraju S and Lewis J A 2019 Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channelsSci. Adv.5eaaw2459

[19] [19] Lai B-Qet al2018 A modular assembly of spinal cord-like tissue allows targeted tissue repair in the transected spinal cordAdv. Sci.51800261

[20] [20] Noor N, Shapira A, Edri R, Gal I, Wertheim L and Dvir T 2019 3D printing of personalized thick and perfusable cardiac patches and heartsAdv. Sci.61900344

[21] [21] Shao L, Gao Q, Xie C Q, Fu J Z, Xiang M X and He Y 2020 Directly coaxial 3D bioprinting of large-scale vascularized tissue constructsBiofabrication12035014

[22] [22] Koffler Jet al2019 Biomimetic 3D-printed scaffolds for spinal cord injury repairNat. Med.25263–9

[23] [23] Choi Set al2023 Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventriclesNat. Mater.221039–46

[24] [24] Baptista L S, Kronemberger G S, Crtes I, Charelli L E, Matsui R A M, Palhares T N, Sohier J, Rossi A M and Granjeiro J M 2018 Adult stem cells spheroids to optimize cell colonization in scaffolds for cartilage and bone tissue engineeringInt. J. Mol. Sci.191285

[25] [25] Bolaos Quiones V A, Zhu H, Solovev A A, Mei Y F and Gracias D H 2018 Origami biosystems: 3D assembly methods for biomedical applicationsAdv. Biosyst.21800230

[26] [26] Datta P, Vyas V, Dhara S, Chowdhury A R and Barui A 2019 Anisotropy properties of tissues: a basis for fabrication of biomimetic anisotropic scaffolds for tissue engineeringJ. Bionics Eng.16842–68

[27] [27] Harmansa S, Erlich A, Eloy C, Zurlo G and Lecuit T 2023 Growth anisotropy of the extracellular matrix shapes a developing organNat. Commun.141220

[28] [28] Chansoria Pet al2022 Rationally designed anisotropic and auxetic hydrogel patches for adaptation to dynamic organsAdv. Funct. Mater.322207590

[29] [29] Khuu N, Kheiri S and Kumacheva E 2021 Structurally anisotropic hydrogels for tissue engineeringTrends Chem.31002–26

[30] [30] Jana S, Levengood S K L and Zhang M Q 2016 Anisotropic materials for skeletal-muscle-tissue engineeringAdv. Mater.2810588–612

[31] [31] Sano K, Ishida Y and Aida T 2018 Synthesis of anisotropic hydrogels and their applicationsAngew. Chem., Int. Ed.572532–43

[32] [32] Li Y H, Huang G Y, Zhang X H, Wang L, Du Y N, Lu T J and Xu F 2014 Engineering cell alignmentin vitro Biotechnol. Adv.32347–65

[33] [33] Prang P, Mller R, Eljaouhari A, Heckmann K, Kunz W, Weber T, Faber C, Vroemen M, Bogdahn U and Weidner N 2006 The promotion of oriented axonal regrowth in the injured spinal cord by alginate-based anisotropic capillary hydrogelsBiomaterials273560–9

[34] [34] Marelli B, Ghezzi C E, James-Bhasin M and Nazhat S N 2015 Fabrication of injectable, cellular, anisotropic collagen tissue equivalents with modular fibrillar densitiesBiomaterials37183–93

[35] [35] Simitzi C, Vlahovic M, Georgiou A, Keskin-Erdogan Z, Miller J and Day R M 2020 Modular orthopaedic tissue engineering with implantable microcarriers and canine adipose-derived mesenchymal stromal cellsFront. Bioeng. Biotechnol.8816

[36] [36] Ni R P, Luo C, Ci H, Sun D, An R, Wang Z X, Yang J, Li Y Q and Sun J M 2023 Construction of vascularized tissue-engineered breast with dual angiogenic and adipogenic micro-tissuesMater. Today Bio18100539

[37] [37] Jang J W, Min K E, Kim C, Shin J, Lee J and Yi S 2023 Review: scaffold characteristics, fabrication methods, and biomaterials for the bone tissue engineeringInt. J. Precis. Eng. Manuf.24511–29

[38] [38] Richards D, Jia J, Yost M, Markwald R and Mei Y 2017 3D bioprinting for vascularized tissue fabricationAnn. Biomed. Eng.45132–47

[39] [39] Masson-Meyers D S and Tayebi L 2021 Vascularization strategies in tissue engineering approaches for soft tissue repairJ. Tissue Eng. Regen. Med.15747–62

[40] [40] Budharaju H, Subramanian A and Sethuraman S 2021 Recent advancements in cardiovascular bioprinting and bioprinted cardiac constructsBiomater. Sci.91974–94

[41] [41] Jain R K, Au P, Tam J, Duda D G and Fukumura D 2005 Engineering vascularized tissueNat. Biotechnol.23821–3

[42] [42] Leferink A M, Tibbe M P, Bossink E G B M, De Heus L E, Van Vossen H, Van Den Berg A, Moroni L and Truckenmller R K 2019 Shape-defined solid micro-objects from poly (d, l-lactic acid) as cell-supportive counterparts in bottom-up tissue engineeringMater. Today Bio4100025

[43] [43] Heo D N, Ayan B, Dey M, Banerjee D, Wee H, Lewis G S and Ozbolat I T 2021 Aspiration-assisted bioprinting of co-cultured osteogenic spheroids for bone tissue engineeringBiofabrication13015013

[44] [44] Pang Y, Sutoko S, Wang Z T, Horimoto Y, Montagne K, Horiguchi I, Shinohara M, Danoy M, Niino T and Sakai Y 2020 Organization of liver organoids using raschig ring-like micro-scaffolds and triple co-culture: toward modular assembly-based scalable liver tissue engineeringMed. Eng. Phys.7669–78

[45] [45] Pang Yet al2019 Biodegradable and hollowed micro-scaffolds for improved modular assembly-based tissue engineering: design, 3D fabrication, and feasibility in randomly packed perfusion cultureBiochem. Eng. J.149107239

[46] [46] Huang Y Q, Karsai A, Sambre P D, Su W C, Faller R, Parikh A N and Liu G Y 2023 Production of lipid constructs by design via three-dimensional nanoprintingMicromachines14372

[47] [47] Liu Zet al2023 High-resolution 3D printing of angle-ply annulus fibrosus scaffolds for intervertebral disc regenerationBiofabrication15015015

[48] [48] Murphy C A, Lim K S and Woodfield T B F 2022 Next evolution in organ-scale biofabrication: bioresin design for rapid high-resolution vat polymerizationAdv. Mater.342107759

[49] [49] Lim K Set al2018 Bio-resin for high resolution lithography-based biofabrication of complex cell-laden constructsBiofabrication10034101

[50] [50] Xing J Y, Liu N, Xu N N, Chen W J and Xing D M 2022 Engineering complex anisotropic scaffolds beyond simply uniaxial alignment for tissue engineeringAdv. Funct. Mater.322110676

[51] [51] Liu J S and Gartner Z J 2012 Directing the assembly of spatially organized multicomponent tissues from the bottom upTrends Cell Biol.22683–91

[52] [52] Ouyang L L, Armstrong J P K, Chen Q, Lin Y Y and Stevens M M 2020 Void-free 3D bioprinting forin situendothelialization and microfluidic perfusionAdv. Funct. Mater.301909009

[53] [53] Fang H M, Ju J Y, Chen L F, Zhou M R, Zhang G, Hou J F, Jiang W B, Wang Z X and Sun J M 2024 Clay Sculpture-inspired 3D printed microcage module using bioadhesion assembly for specific-shaped tissue vascularization and regenerationAdv. Sci.112308381

[54] [54] Ahmad T, Byun H, Lee J, Perikamana S K M, Shin Y M, Kim E M and Shin H 2020 Stem cell spheroids incorporating fibers coated with adenosine and polydopamine as a modular building blocks for bone tissue engineeringBiomaterials230119652

[55] [55] Rago A P, Dean D M and Morgan J R 2009 Controlling cell position in complex heterotypic 3D microtissues by tissue fusionBiotechnol. Bioeng.1021231–41

[56] [56] Haraguchi Yet al2012 Fabrication of functional three-dimensional tissues by stacking cell sheetsin vitro Nat. Protocols7850–

[57] [57] De Souza N 2018 OrganoidsNat. Methods1523

[58] [58] Tian A L, Xue J S and Sun N F 2022 Advantages of self-assembled Nano peptide hydrogels in biological tissue engineeringCurr. Protein Pept. Sci.23395–401

[59] [59] Tang Het al2023 A bioengineered trachea-like structure improves survival in a rabbit tracheal defect modelSci. Transl. Med.15eabo4272

[60] [60] Mi S L, Yang S T, Liu T K, Du Z C, Xu Y Y, Li B H and Sun W 2019 A novel controllable cell array printing technique on microfluidic chipsIEEE Trans. Biomed. Eng.662512–20

[61] [61] Morimoto Y, Kiyosawa M and Takeuchi S 2018 Three-dimensional printed microfluidic modules for design changeable coaxial microfluidic devicesSens. ActuatorsB274491–500

[62] [62] Zhu Wet al2017 Direct 3D bioprinting of prevascularized tissue constructs with complex microarchitectureBiomaterials124106–15

[63] [63] Kamperman T, Karperien M, Le Gac S and Leijten J 2018 Single-cell microgels: technology, challenges, and applicationsTrends Biotechnol.36850–65

[64] [64] Yu Y R, Shang L R, Guo J H, Wang J and Zhao Y J 2018 Design of capillary microfluidics for spinning cell-laden microfibersNat. Protocols132557–79

[65] [65] Leng L, McAllister A, Zhang B Y, Radisic M and Gnther A 2012 Mosaic hydrogels: one-step formation of multiscale soft materialsAdv. Mater.243650–8

[66] [66] Ouyang L L, Yao R, Mao S S, Chen X, Na J and Sun W 2015 Three-dimensional bioprinting of embryonic stem cells directs highly uniform embryoid body formationBiofabrication7044101

[67] [67] Giandomenico S Let al2019 Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional outputNat. Neurosci.22669–79

[68] [68] Gantumur E, Kimura M, Taya M, Horie M, Nakamura M and Sakai S 2019 Inkjet micropatterning through horseradish peroxidase-mediated hydrogelation for controlled cell immobilization and microtissue fabricationBiofabrication12011001

[69] [69] McGuigan A P, Leung B and Sefton M V 2006 Fabrication of cells containing gel modules to assemble modular tissue-engineered constructsNat. Protocols12963–9

[70] [70] Nokhbatolfoghahaei H, Bastami F, Farzad-Mohajeri S, Rad M R, Dehghan M M, Bohlouli M, Farajpour H, Nadjmi N and Khojasteh A 2022 Prefabrication technique by preserving a muscular pedicle from masseter muscle as anin vivobioreactor for reconstruction of mandibular critical-sized bone defects in canine modelsJ. Biomed. Mater. Res.1101675–86

[71] [71] Khorramirouz R, Kameli S M, Eftekharzadeh S and Kajbafzadeh A M 2017 Application of omentum as anin vivobioreactor for regeneration of decellularized human internal mammary arteryJ. Biomed. Mater. Res.1052685–93

[72] [72] Bouyer C, Chen P, Gven S, DemirtaT T, Nieland T J F, Padilla F and Demirci U 2016 A bio-acoustic levitational (BAL) assembly method for engineering of multilayered, 3D brain-like constructs, using human embryonic stem cell derived neuro-progenitorsAdv. Mater.28161–7

[73] [73] Lewis E E L, Wheadon H, Lewis N, Yang J L, Mullin M, Hursthouse A, Stirling D, Dalby M J and Berry C C 2016 A quiescent, regeneration-responsive tissue engineered mesenchymal stem cell bone marrow niche model via magnetic levitationACS Nano108346–54

[74] [74] Kang D, Hong S, Kim S J, Choi H, Kim K and Jang J 2024 Robotics-assisted modular assembly of bioactive soft materials for enhanced organ fabricationVirtual Phys. Prototyp.19e2390484

[75] [75] Tatara A M, Wong M E and Mikos A G 2014In vivobioreactors for mandibular reconstructionJ. Dent. Res.931196–202

[76] [76] Yap K K, Yeoh G C, Morrison W A and Mitchell G M 2018 The vascularised chamber as anin vivobioreactorTrends Biotechnol.361011–24

[77] [77] Tatara A Met al2019 Biomaterials-aided mandibular reconstruction usingin vivobioreactorsProc. Natl Acad. Sci. USA1166954–63

[78] [78] Holt G E, Halpern J L, Dovan T T, Hamming D and Schwartz H S 2005 Evolution of anin vivobioreactorJ. Orthop. Res.23916–23

[79] [79] Xu Y Yet al2020 Bioengineered carina reconstruction usingin-vivobioreactor technique in human: proof of concept studyTransl. Lung Cancer Res.9705–12

[80] [80] Cheng M H, Brey E M, Ulusal B G and Wei F C 2006 Mandible augmentation for osseointegrated implants using tissue engineering strategiesPlast. Reconstr. Surg.1181e–4e

[81] [81] Huang R L, Tremp M, Ho C K, Sun Y B, Liu K and Li Q F 2017 Prefabrication of a functional bone graft with a pedicled periosteal flap as anin vivobioreactorSci. Rep.718038

[82] [82] Zhang H F, Mao X Y, Zhao D Y, Jiang W B, Du Z J, Li Q F, Jiang C H and Han D 2017 Three dimensional printed polylactic acid-hydroxyapatite composite scaffolds for prefabricating vascularized tissue engineered bone: anin vivobioreactor modelSci. Rep.715255

[83] [83] Tatara A M, Shah S R, Demian N, Ho T, Shum J, Van Den Beucken J J, Jansen J A, Wong M E and Mikos A G 2016 Reconstruction of large mandibular defects using autologous tissues generated fromin vivobioreactorsActa Biomater.4572–84

[84] [84] Liu Y M, Mller B, Wiltfang J, Warnke P H and Terheyden H 2014 Tissue engineering of a vascularized bone graft of critical size with an osteogenic and angiogenic factor-basedin vivobioreactorTissue Eng.A203189–97

[85] [85] Abu-Shahba A G, Wilkman T, Kornilov R, Adam M, Salla K M, Lindn J, Lappalainen A K, Bjrkstrand R, Seppnen-Kaijansinkko R and Mannerstrm B 2022 Periosteal flaps enhance prefabricated engineered bone reparative potentialJ. Dent. Res.101166–76

[86] [86] Huang R L, Kobayashi E, Liu K and Li Q F 2016 Bone graft prefabrication following thein vivobioreactor principleEBioMedicine1243–54

[87] [87] Huang R L, Chen G, Wang W J, Herller T, Xie Y, Gu B and Li Q F 2015 Synergy between IL-6 and soluble IL-6 receptor enhances bone morphogenetic protein-2/absorbable collagen sponge-induced bone regeneration via regulation of BMPRIA distribution and degradationBiomaterials67308–22

[88] [88] Sun W Y, Zhang J H, Qin Y C, Tang H, Chen Y, Lin W K, She Y L, Zhang K X, Yin J B and Chen C 2022 A simple and efficient strategy for preparing a cell-spheroid-based bioinkAdv. Healthcare Mater.112200648

[89] [89] Yang Y Pet al2021 Investigation of a prevascularized bone graft for large defects in the ovine tibiaTissue Eng.A271458–69

[90] [90] Horch R E, Beier J P, Kneser U and Arkudas A 2014 Successful human long-term application ofin situbone tissue engineeringJ. Cell Mol. Med.181478–85

[91] [91] Baumert H, Simon P, Hekmati M, Fromont G, Levy M, Balaton A, Molini V and Malavaud B 2007 Development of a seeded scaffold in the great omentum: feasibility of anin vivobioreactor for bladder tissue engineeringEur. Urol.52884–92

[92] [92] Park H S, Lee J S, Jung H, Kim D Y, Kim S W, Sultan M T and Park C H 2018 An omentum-cultured 3D-printed artificial trachea:in vivobioreactorArtif. Cells Nanomed. Biotechnol.461131–40

[93] [93] Rogers S A, Lowell J A, Hammerman N A and Hammerman M R 1998 Transplantation of developing metanephroi into adult ratsKidney Int.5427–37

[94] [94] Chung E J, Ju H W, Yeon Y K, Lee J S, Lee Y J, Seo Y B and Hum P C 2018 Development of an omentum-cultured oesophageal scaffold reinforced by a 3D-printed ring: feasibility of anin vivobioreactorArtif. Cells Nanomed. Biotechnol.46885–95

[95] [95] Sameti M and Bashur C A 2022 Peritoneal pre-conditioning method forin vivovascular graft maturation utilizing a porous pouchVascular Tissue Engineering: Methods and Protocolsed F Zhao and K W Leong (Springer) pp 91–99

[96] [96] Imberti Bet al2015 Renal primordia activate kidney regenerative events in a rat model of progressive renal diseasePLoS One10e0120235

[97] [97] Yang M Let al2023 Scaffold-free tracheal engineering via a modular strategy based on cartilage and epithelium sheetsAdv. Healthcare Mater.122202022

[98] [98] Sun Y Yet al2024 Instant trachea reconstruction using 3D-bioprinted C-shape biomimetic trachea based on tissue-specific matrix hydrogelsBioact. Mater.3252–65

[99] [99] Radisic M, Malda J, Epping E, Geng W L, Langer R and Vunjak-Novakovic G 2006 Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissueBiotechnol. Bioeng.93332–43

[100] [100] Wilson R L, Connell J P and Grande-Allen K J 2019 Monitoring oxygen levels within large, tissue-engineered constructs using porphyin-hydrogel microparticlesACS Biomater. Sci. Eng.54522–30

[101] [101] Miller J S 2014 The billion cell construct: will three-dimensional printing get us there?PLoS Biol.12e1001882

[102] [102] Sun X, Yao F L, Zhang H and Li J H 2022 Oxygen-generating materials and their biomedical applications: a reviewJ. Mater. Sci.579077–103

[103] [103] Wang Y Het al2022 3D printed integrated bionic oxygenated scaffold for bone regenerationACS Appl. Mater. Interfaces1429506–20

[104] [104] Augustine R, Gezek M, Bostanci N S, Nguyen A and Camci-Unal G 2023 Oxygen-generating scaffolds: one step closer to the clinical translation of tissue engineered productsChem. Eng. J.455140783

[105] [105] Morgan K Y, Sklaviadis D, Tochka Z L, Fischer K M, Hearon K, Morgan T D, Langer R and Freed L E 2016 Multi-material tissue engineering scaffold with hierarchical pore architectureAdv. Funct. Mater.265873–83

[106] [106] Li Z Q, Guo X L and Guan J J 2012 An oxygen release system to augment cardiac progenitor cell survival and differentiation under hypoxic conditionBiomaterials335914–23

[107] [107] Li H Y, Iyer K S, Bao L, Zhai J L and Li J J 2023 Advances in the development of granular microporous injectable hydrogels with non-spherical microgels and their applications in tissue regenerationAdv. Healthcare Mater.132301597

[108] [108] Song J E, Tripathy N, Cha S R, Jeon S H, Kwon S Y, Suh D S and Khang G 2017 Three-dimensional duck's feet collagen/PLGA scaffold for chondrification: role of pore size and porosityJ. Biomater. Sci., Polym. Ed.29932–41

[109] [109] Fiedler T, Belova I V, Murch G E, Poologasundarampillai G, Jones J R, Roether J A and Boccaccini A R 2014 A comparative study of oxygen diffusion in tissue engineering scaffoldsJ. Mater. Sci., Mater. Med.252573–8

[110] [110] Hwang S-Cet al2019 Development of bone regeneration strategies using human periosteum-derived osteoblasts and oxygen-releasing microparticles in mandibular osteomyelitis model of miniature pigJ. Biomed. Mater. Res.1072183–94

[111] [111] Abdullah T, Gauthaman K, Hammad A H, Joshi Navare K, Alshahrie A A, Bencherif S A, Tamayol A and Memic A 2020 Oxygen-releasing antibacterial nanofibrous scaffolds for tissue engineering applicationsPolymers121233

[112] [112] Nejati S, Karimi Soflou R, Khorshidi S and Karkhaneh A 2020 Development of an oxygen-releasing electroconductivein-situcrosslinkable hydrogel based on oxidized pectin and grafted gelatin for tissue engineering applicationsColloids Surf.B196111347

[113] [113] Agarwal Tet al2021 Oxygen releasing materials: towards addressing the hypoxia-related issues in tissue engineeringMater. Sci. Eng.C122111896

[114] [114] Ashammakhi N, Darabi M A, Kehr N S, Erdem A, Hu S K, Dokmeci M R, Nasr A S and Khademhosseini A 2020 Advances in controlled oxygen generating biomaterials for tissue engineering and regenerative therapyBiomacromolecules2156–72

[115] [115] Sawyer S W, Zhang K R, Horton J A and Soman P 2020 Perfusion-based co-culture model system for bone tissue engineeringAIMS Bioeng.791–105

[116] [116] Takei T, Sakai S, Yokonuma T, Ijima H and Kawakami K 2007 Fabrication of artificial endothelialized tubes with predetermined three-dimensional configuration from flexible cell-enclosing alginate fibersBiotechnol. Prog.23182–6

[117] [117] Kang H W, Lee S J, Ko I K, Kengla C, Yoo J J and Atala A 2016 A 3D bioprinting system to produce human-scale tissue constructs with structural integrityNat. Biotechnol.34312–9

[118] [118] Kreuels K, Schemmer C, Flesch M F and Gillner A 2023 3D-printed scaffolds with perfusable channels for low-cost large construct 3D cell cultureCurr. Dir. Biomed. Eng.9662–5

[119] [119] Parkhideh S, Calderon G A, Janson K D, Mukherjee S, Mai A K, Doerfert M D, Yao Z R, Sazer D W and Veiseh O 2023 Perfusable cell-laden matrices to guide patterning of vascularizationin vivo Biomater. Sci.11461–71

[120] [120] Zhao Y T, Zhang J, Gao Y, Liu X F, Liu J J, Wang X X, Xiang H F and Long Y Z 2020 Self-powered portable melt electrospinning forin situwound dressingJ. Nanobiotechnol.18111

[121] [121] Oh S H, Ward C L, Atala A, Yoo J J and Harrison B S 2009 Oxygen generating scaffolds for enhancing engineered tissue survivalBiomaterials30757–62

[122] [122] Ren B, Song K D, Chen Y X, Murfee W L and Huang Y 2023 Laponite nanoclay-modified sacrificial composite ink for perfusable channel creation via embedded 3D printingCompositesB263110851

[123] [123] Guo G P, Ma Y, Guo Y, Zhang C B, Guo X S, Tu J, Yu A C H, Wu J R and Zhang D 2017 Enhanced porosity and permeability of three-dimensional alginate scaffolds via acoustic microstreaming induced by low-intensity pulsed ultrasoundUltrason. Sonochem.37279–85

[124] [124] Paciello A, Amalfitano G, Garziano A, Urciuolo F and Netti P A 2016 Hemoglobin-conjugated gelatin microsphere as a smart oxygen releasing biomaterialAdv. Healthcare Mater.52655–66

[125] [125] Hu J L, Wang Q, Wang Y, You G X, Li P L, Zhao L and Zhou H 2020 Polydopamine-based surface modification of hemoglobin particles for stability enhancement of oxygen carriersJ. Colloid Interface Sci.571326–36

[126] [126] Wang X S, Lin M H and Kang Y Q 2019 Engineering porous -tricalcium phosphate (-TCP) scaffolds with multiple channels to promote cell migration, proliferation, and angiogenesisACS Appl. Mater. Interfaces119223–32

[127] [127] Dong Y, Chen A N, Yang T, Gao S, Liu S N, Jiang H Y, Shi Y S and Hu C L 2023 Ultra-lightweight ceramic scaffolds with simultaneous improvement of pore interconnectivity and mechanical strengthJ. Mater. Sci. Technol.137247–58

[128] [128] Ma Tet al2020 Oxygen carrier in core-shell fibers synthesized by coaxial electrospinning enhances Schwann cell survival and nerve regenerationTheranostics108957–73

[129] [129] Gao B T, Jing H, Gao M C, Wang S B, Fu W, Zhang X Y, He X M and Zheng J H 2019 Long-segmental tracheal reconstruction in rabbits with pedicled Tissue-engineered trachea based on a 3D-printed scaffoldActa Biomater.97177–86

[130] [130] Szklanny A Aet al2021 3D bioprinting of engineered tissue flaps with hierarchical vessel networks (VesselNet) for direct host-to-implant perfusionAdv. Mater.332102661

[131] [131] Avolio E, Alvino V V, Ghorbel M T and Campagnolo P 2017 Perivascular cells and tissue engineering: current applications and untapped potentialPharmacol. Ther.17183–92

[132] [132] Mastrullo V, Cathery W, Velliou E, Madeddu P and Campagnolo P 2020 Angiogenesis in tissue engineering: as nature intended?Front. Bioeng. Biotechnol.8188

[133] [133] Rouwkema J and Khademhosseini A 2016 Vascularization and angiogenesis in tissue engineering: beyond creating static networksTrends Biotechnol.34733–45

[134] [134] Shah Mohammadi M, Buchen J T, Pasquina P F, Niklason L E, Alvarez L M and Jariwala S H 2021 Critical considerations for regeneration of vascularized composite tissuesTissue Eng.B27366–81

[135] [135] Rademakers T, Horvath J M, Blitterswijk C A and LaPointe V L S 2019 Oxygen and nutrient delivery in tissue engineering: approaches to graft vascularizationJ. Tissue Eng. Regen. Med.131815–29

[136] [136] Son J, Mohamed H J, Ha W N, Naren A, Choi C, Kwon Y H, Park S, Joung H C and Kang H W 2023 Bioprinting of pre-vascularized constructs for enhancedin vivoneo-vascularizationBiofabrication15034101

[137] [137] Xu J, Shen J J, Sun Y C, Wu T Y, Sun Y X, Chai Y M, Kang Q L, Rui B Y and Li G 2022In vivoprevascularization strategy enhances neovascularization of -tricalcium phosphate scaffolds in bone regenerationJ. Orthop. Transl.37143–51

[138] [138] Wang H Ket al2023 Neural tissue-engineered prevascularizationin vivoenhances peripheral neuroregeneration via rapid vascular inosculationMater. Today Bio21100718

[139] [139] Wang L, Fan H B, Zhang Z Y, Lou A J, Pei G X, Jiang S, Mu T W, Qin J J, Chen S Y and Jin D 2010 Osteogenesis and angiogenesis of tissue-engineered bone constructed by prevascularized -tricalcium phosphate scaffold and mesenchymal stem cellsBiomaterials319452–61

[140] [140] Mastrullo V, Van Der Veen D R, Gupta P, Matos R S, Johnston J D, McVey J H, Madeddu P, Velliou E and Campagnolo P 2022 Pericytes' circadian clock affects endothelial cells'synchronization and angiogenesis in a 3D tissue engineered scaffoldFront. Pharmacol.13867070

[141] [141] Wu J, Wu Z, Xue Z Q, Li H Y and Liu J B 2017 PHBV/bioglass composite scaffolds with co-cultures of endothelial cells and bone marrow stromal cells improve vascularization and osteogenesis for bone tissue engineeringRSC Adv.722197–07

[142] [142] Wan X Z, Li P F, Jin X X, Su F, Shen J and Yuan J 2019 Poly (-caprolactone)/keratin/heparin/VEGF biocomposite mats for vascular tissue engineeringJ. Biomed. Mater. Res.A108292–300

[143] [143] Ding M H, Lozoya E G, Rico R N and Chew S A 2020 The role of angiogenesis-inducing microRNAs in vascular tissue engineeringTissue Eng.A261283–302

[144] [144] Koike N, Fukumura D, Gralla O, Au P, Schechner J S and Jain R K 2004 Creation of long-lasting blood vesselsNature428138–9

[145] [145] Tsigkou Oet al2010 Engineered vascularized bone graftsProc. Natl Acad. Sci. USA1073311–6

[146] [146] Sun J X, Wang Y L, Qian Z Y and Hu C B 2011 An approach to architecture 3D scaffold with interconnective microchannel networks inducing angiogenesis for tissue engineeringJ. Mater. Sci., Mater. Med.222565–71

[147] [147] Xia P and Luo Y X 2022 Vascularization in tissue engineering: the architecture cues of pores in scaffoldsJ. Biomed. Mater. Res.1101206–14

[148] [148] Shen J J, Wang J Y, Liu X Z, Sun Y, Yin A L, Chai Y M, Zhang K H, Wang C Y and Zheng X Y 2021In situprevascularization strategy with three-dimensional porous conduits for neural tissue engineeringACS Appl. Mater. Interfaces1350785–801

[149] [149] Druecke D, Langer S, Lamme E, Pieper J, Ugarkovic M, Steinau H U and Homann H H 2004 Neovascularization of poly (ether ester) block-copolymer scaffoldsin vivo: long-term investigations using intravital fluorescent microscopyJ. Biomed. Mater. Res.A6810–18

[150] [150] Zieber L, Or S, Ruvinov E and Cohen S 2014 Microfabrication of channel arrays promotes vessel-like network formation in cardiac cell construct and vascularizationin vivo Biofabrication6024102

[151] [151] Barreto-Ortiz S F, Fradkin J, Eoh J, Trivero J, Davenport M, Ginn B, Mao H Q and Gerecht S 2015 Fabrication of 3-dimensional multicellular microvascular structuresFASEB J.293302–14

[152] [152] Gui L Q and Niklason L E 2014 Vascular tissue engineering: building perfusable vasculature for implantationCurr. Opin. Chem. Eng.368–74

[153] [153] Shao L, Gao Q, Xie C Q, Fu J Z, Xiang M X and He Y 2020 Synchronous 3D bioprinting of large-scale cell-laden constructs with nutrient networksAdv. Healthcare Mater.91901142

[154] [154] Ghosh U, Ning S, Wang Y Z and Kong Y L 2018 Addressing unmet clinical needs with 3D printing technologiesAdv. Healthcare Mater.71800417

[155] [155] Murphy S V and Atala A 2014 3D bioprinting of tissues and organsNat. Biotechnol.32773–85

[156] [156] Liu S Y, Liu S, Li S M, Liang B R, Han X, Liang Y H and Wei X 2023 Nerves within bone and their application in tissue engineering of bone regenerationFront. Neurol.131085560

[157] [157] Banerjee D, Nayakawde N B, Antony D, Deshmukh M, Ghosh S, Sihlbom C, Berger E, Ul Haq U and Olausson M 2022 Characterization of decellularized implants for extracellular matrix integrity and immune response elicitationTissue Eng.A28621–39

[158] [158] Wiles K, Fishman J M, De Coppi P and Birchall M A 2016 The host immune response to tissue-engineered organs: current problems and future directionsTissue Eng.B22208–19

[159] [159] Ochando J, Charron D, Baptista P M and Uygun B E 2017 Immune responses to bioengineered organsCurr. Opin. Organ Transplant.2279–85

[160] [160] Angeletti A, Cantarelli C and Cravedi P 2019 Immune responses towards bioengineered tissues and strategies to control themCurr. Opin. Organ Transplant.24582–9

[161] [161] Zhang Z, Hao Z C, Xian C H, Fang Y F, Cheng B, Wu J and Xia J 2022 Neuro-bone tissue engineering: multiple potential translational strategies between nerve and boneActa Biomater.1531–12

[162] [162] Sugiura T, Matsumura G, Miyamoto S, Miyachi H, Breuer C K and Shinoka T 2018 Tissue-engineered vascular grafts in children with congenital heart disease: intermediate term follow-upSemin. Thoracic Cardiovascular Surg.30175–9

[163] [163] Llames Set al2006 Clinical results of an autologous engineered skinCell Tissue Bank747–53

[164] [164] Menasch Pet al2018 Transplantation of human embryonic stem cell-derived cardiovascular progenitors for severe ischemic left ventricular dysfunctionJ. Am. Coll. Cardiol.71429–38

[165] [165] Ferrarotti F, Romano F, Gamba M N, Quirico A, Giraudi M, Audagna M and Aimetti M 2018 Human intrabony defect regeneration with micrografts containing dental pulp stem cells: a randomized controlled clinical trialJ. Clin. Periodontol.45841–50

[166] [166] Grigoryan Bet al2019 Multivascular networks and functional intravascular topologies within biocompatible hydrogelsScience364458–64

[167] [167] Sarkiri M, Fox S C, Fratila-Apachitei L E and Zadpoor A A 2019 Bioengineered skin intended for skin disease modelingInt. J. Mol. Sci.201407

[168] [168] Pountos I, Tellisi N and Ashammakhi N 2019 Three-dimensional bioprinting: safety, ethical, and regulatory considerations3D Bioprinting in Medicine: Technologies, Bioinks, and Applicationsed M Guvendiren (Springer) pp 191–203

[169] [169] Boehler R M, Graham J G and Shea L D 2011 Tissue engineering tools for modulation of the immune responseBioTechniques51239–54

[170] [170] Pullen L C 2022 Bioengineered organs: not a matter of “if”Am. J. Transplant.221–2

[171] [171] Birchall M A 2009 Cell-and tissue-engineered organ replacementsBr. J. Surg.96565–6

[172] [172] Hirayama M, Oshima M and Tsuji T 2013 Development and prospects of organ replacement regenerative therapyCornea32S13–21

[173] [173] Seetapun D and Ross J J 2017 Eliminating the organ transplant waiting list: the future with perfusion decellularized organsSurgery1611474–8

[174] [174] Goyer B, Larouche D, Kim D H, Veillette N, Pruneau V, Bernier V, Auger F A and Germain L 2019 Immune tolerance of tissue-engineered skin produced with allogeneic or xenogeneic fibroblasts and syngeneic keratinocytes grafted on miceActa Biomater.90192–204

[175] [175] Reuther M and Watson D 2016 Tissue engineering and the future of facial volumizationFacial Plast. Surg.32565–8

Tools

Get Citation

Copy Citation Text

Bai Qingfeng, Tang Hai, Chen Yi, Pan Ziyin, Lin Weikang, Wang Lei, Hu Yulong, Xu Boyu, Yang Minglei, Zhao Guofang, Sun Weiyan, He Yong, Chen Chang. Modular strategy with autologous bioreactor: a potential way for organ engineering[J]. International Journal of Extreme Manufacturing, 2025, 7(2): 22001

Download Citation

EndNote(RIS)BibTexPlain Text
Save article for my favorites
Paper Information

Category:

Received: May. 20, 2024

Accepted: May. 29, 2025

Published Online: May. 29, 2025

The Author Email:

DOI:10.1088/2631-7990/ad92c9

Topics