Local-Connection-Network-Based Reconstruction Method for Cerenkov Luminescence Tomography

Weitong Li; Haolin Wang; Kang Li; Guohua Geng; Mingquan Zhou; Xin Cao

doi:10.3788/LOP202259.0617031

Laser & Optoelectronics Progress, Volume. 59, Issue 6, 0617031(2022)

Local-Connection-Network-Based Reconstruction Method for Cerenkov Luminescence Tomography

Weitong Li¹, Haolin Wang¹, Kang Li¹, Guohua Geng¹, Mingquan Zhou², and Xin Cao^1、*

Author Affiliations

¹School of Information Science & Technology, Northwest University, Xi'an , Shaanxi 710127, China

²College of Information Science and Technology, Beijing Normal University, Beijing 100875, China

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Figures & Tables(12)

Fig. 1. FES-LCN structure

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Fig. 2. Research object of inhomogeneous cylinder simulation experiment. (a) Inhomogeneous cylinder model; (b) example of grid model of inhomogeneous cylinder; (c) example of forward simulation result of inhomogeneous cylinder

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Fig. 3. Reconstructed results in inhomogeneous cylinder simulation experiment with single light source. (a) Stereogram reconstructed by IVTCG; (b) stereogram reconstructed by MFCNN; (c) stereogram reconstructed by FES-LCN; (d) two-dimensional section of reconstructed result for IVTCG; (e) two-dimensional section of reconstructed result for MFCNN; (f) two-dimensional section of reconstructed result for FES-LCN

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Fig. 4. Reconstruction results in inhomogeneous cylinder simulation experiment with dual light source. (a) Stereogram reconstructed by IVTCG; (b) stereogram reconstructed by MFCNN; (c) stereogram reconstructed by FES-LCN; (d) two-dimensional section of reconstructed result for IVTCG; (e) two-dimensional section of reconstructed result for MFCNN; (f) two-dimensional section of reconstructed result for FES-LCN

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Fig. 5. Research object of digital mouse simulation experiment. (a) Digital mouse model; (b) example of grid model of digital mouse; (c) example of forward simulation result of digital mouse

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Fig. 6. Reconstruction results in digital mouse simulation experiment with single light source. (a) Stereogram reconstructed by IVTCG; (b) stereogram reconstructed by MFCNN; (c) stereogram reconstructed by FES-LCN; (d) two-dimensional section of reconstructed result for IVTCG; (e) two-dimensional section of reconstructed result for MFCNN; (f) two-dimensional section of reconstructed result for FES-LCN

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Fig. 7. Reconstruction results in digital mouse simulation experiment with dual light source. (a) Stereogram reconstructed by IVTCG; (b) stereogram reconstructed by MFCNN; (c) stereogram reconstructed by FES-LCN; (d) two-dimensional section of reconstructed result for IVTCG; (e) two-dimensional section of reconstructed result for MFCNN; (f) two-dimensional section of reconstructed result for FES-LCN

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Table 1. Optical parameters of inhomogeneous cylinder
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Table 1. Optical parameters of inhomogeneous cylinder
Material $μ_{a x}$ /mm^-1 $μ_{s x}$ /mm^-1
Muscle 0.0052 10.8
Heart 0.0083 6.733
Lung 0.0133 19.7
Liver 0.0329 7.0
Bone 0.0060 60.09

Table 2. Results of three reconstruction methods in inhomogeneous cylinder simulation experiment with single light source

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Table 2. Results of three reconstruction methods in inhomogeneous cylinder simulation experiment with single light source

Method	Coordinate of the center of reconstructed light source	Coordinate of the point with maximum energy	$E_{C}$	$E_{L}$	$R_{T V}$
IVTCG	（-1.65，3.18，10.87）	（-1.60，2.95，11.01）	0.682	0.603	0.57
MFCNN	（-1.12，2.92，11.08）	（-1.60，2.95，11.01）	0.171	0.603	1.23
FES-LCN	（-1.12，2.92，11.08）	（-0.87，3.45，11.05）	0.171	0.469	0.68

Table 3. Results of three reconstruction methods in inhomogeneous cylinder simulation experiment with dual light source

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Table 3. Results of three reconstruction methods in inhomogeneous cylinder simulation experiment with dual light source

Method

Coordinate of center of reconstructed light source

Coordinate of the point with maximum energy

E_{C}

E_{L}

R_{T V}

IVTCG

（-5.61，2.74，8.12）

（-3.02，2.91，9.60）

（-4.31，3.20，8.62）

（-3.37，2.87，9.09）

1.472

2.429

1.52

MFCNN

（-5，65，2.85，8.08）

（-1.07，2.95，10.79）

（-5.48，2.35，8.26）

（-1.6，2.95，11.01）

0.309

0.735

1.06

FES-LCN

（-5，65，2.85，8.08）

（-1.07，2.95，10.79）

（-5.48，2.35，8.26）

（-0.87，3.45，11.05）

0.309

0.668

1.00

Table 4. Results of three reconstruction methods in digital mouse simulation experiment with single light source

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Table 4. Results of three reconstruction methods in digital mouse simulation experiment with single light source

Method	Coordinate of the center of reconstructed light source	Coordinate of the point with maximum energy	$E_{C}$	$E_{L}$	$R_{T V}$
IVTCG	（18.89，7.98，19.24）	（19.40，8.36，19.15）	1.672	1.081	0.43
MFCNN	（18.58，7.21，19.23）	（18.14，7.18，18.61）	0.346	0.981	1
FES-LCN	（18.58，7.21，19.23）	（17.97，6.35，19.35）	0.345	0.852	1

Table 5. Results of three reconstruction methods in digital mouse simulation experiment with dual light source

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Table 5. Results of three reconstruction methods in digital mouse simulation experiment with dual light source

Method

Coordinate of the center of reconstructed light source

Coordinate of the point with maximum energy

E_{C}

E_{L}

R_{T V}

IVTCG

（18.46，11.79，14.67）

（17.98，13.25，22.16）

（18.46，11.79，14.67）

（18.21，13.05，21.68）

0.916

1.065

0.49

MFCNN

（18.42，11.39，15.42）

（18.92，14.98，22.96）

（18.28，10.69，22.96）

（18.72，14.05，23.11）

0.610

0.882

1.54

FES-LCN

（18.42，11.39，15.42）

（18.92，14.98，22.96）

（18.28，10.69，22.96）

（18.08，14.44，22.36）

0.610

0.706

1.53

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Weitong Li, Haolin Wang, Kang Li, Guohua Geng, Mingquan Zhou, Xin Cao. Local-Connection-Network-Based Reconstruction Method for Cerenkov Luminescence Tomography[J]. Laser & Optoelectronics Progress, 2022, 59(6): 0617031

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Paper Information

Category: Medical Optics and Biotechnology

Received: Jun. 22, 2021

Accepted: Sep. 13, 2021

Published Online: Mar. 2, 2022

The Author Email: Xin Cao (xin_cao@163.com)

DOI:10.3788/LOP202259.0617031

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology

Table 1. Optical parameters of inhomogeneous cylinder

Table 1. Optical parameters of inhomogeneous cylinder

Table 2. Results of three reconstruction methods in inhomogeneous cylinder simulation experiment with single light source

Table 2. Results of three reconstruction methods in inhomogeneous cylinder simulation experiment with single light source

Table 3. Results of three reconstruction methods in inhomogeneous cylinder simulation experiment with dual light source

Table 3. Results of three reconstruction methods in inhomogeneous cylinder simulation experiment with dual light source

Table 4. Results of three reconstruction methods in digital mouse simulation experiment with single light source

Table 4. Results of three reconstruction methods in digital mouse simulation experiment with single light source

Table 5. Results of three reconstruction methods in digital mouse simulation experiment with dual light source

Table 5. Results of three reconstruction methods in digital mouse simulation experiment with dual light source