Chinese Journal of Lasers, Volume. 45, Issue 3, 307010(2018)

Photoacoustic Elastography for Biological Tissue

Wang Cheng1, Dong Xiaona1, Cai Gan1, Xiang Huazhong1, Zheng Gang1, and Zhang Dawei2、*
Author Affiliations
  • 1[in Chinese]
  • 2[in Chinese]
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    Figures & Tables(12)
    Structural diagrams of (a) confocal annular array transducer and (b) vibro-acoustography system[7]
    Structural diagram of resonant ARF-OCE system based on spectral-domain OCT system[10]
    Experimental setup of photoacoustic elastography system[11]
    Photoacoustic viscoelasticity imagings of three samples (muscle, fat and liver). (a) Photograph of sample; (b) photoacoustic viscoelasticity imaging of sample[11]
    Detection process of amplitude and phase of photoacoustic signal based on lock-in measurement[18]
    Optical absorption and viscoelasticity images of murine EMT6 tumor. (a) Optical absorption image of the tumor; (b) viscoelasticity image of the tumor; (c) photograph of the tumor; (d) averaged amplitude and phase delay of the photoacoustic signal from the marked tumor region compared to the normal tissue; (e) normal tissue and (f) tumor with hematoxylin-eosin stain[18]
    Schematic of QPAE system. (a) Lateral and front view of photoacoustic imaging probe; (b) QPAE system setup[24]
    QPAE images of the human musculus biceps in vivo at different loadings. (a) 0 kg; (b) 2.5 kg; (c) 5.0 kg; (d) 7.5 kg; (e) 10.0 kg; (f) averaged Young's modulus value in each layer as a function of load[24]
    (a) Photoacoustic elastography images of vertical and en-face expansion scanned by 360° in the interior of the sample; (b) photoacoustic elastography image and the corresponding histology image and phase distribution at z=0.8 mm[27]
    • Table 1. Comparison of various elastography

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      Table 1. Comparison of various elastography

      CharacteristicUEOCEPhotoacousticelastography
      ContrastBadExcellentGood
      SpatialresolutionBadExcellentGood
      Maximumimaging depthExcellentBadGood
    • Table 2. Quantitative characterization of two kinds of tissues[20]

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      Table 2. Quantitative characterization of two kinds of tissues[20]

      ParameterTissue 1 (benign)Tissue 2 (malignant)
      Tr5.6 μs3.5 μs
      Pn52
      Pr6.230.7
    • Table 3. Comparison of photoacoustic elastography methods

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      Table 3. Comparison of photoacoustic elastography methods

      Imaging contrastRelation to photoacoustic signalImaging method
      Phase delay timePhase delay between photoacoustic signal and laser pulseas a function of viscosity-elasticity ratioViscoelasticity
      Relaxation time peaknumbers and peak ratioRelaxation time, peak numbers and peak ratio of photoacousticsignal as a function of viscosityViscoelasticity
      Main frequencyRelation between photoacoustic signal and elastic modulusElastography
      Young's modulusLocal strain measurement gained from photoacoustic imaging'sdifferent displacements before and after compressionElastography
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    Wang Cheng, Dong Xiaona, Cai Gan, Xiang Huazhong, Zheng Gang, Zhang Dawei. Photoacoustic Elastography for Biological Tissue[J]. Chinese Journal of Lasers, 2018, 45(3): 307010

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    Paper Information

    Special Issue:

    Received: Jun. 2, 2017

    Accepted: --

    Published Online: Mar. 6, 2018

    The Author Email: Dawei Zhang (usstoe@vip.163.com)

    DOI:10.3788/CJL201845.0307010

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