To develop an efficient antibacterial coating material, the basic formulas for epoxy acrylate 6215-100 and triepropanediol diacrylate are derived using silicone quaternary ammonium salt (QAC) as an antibacterial agent and fluorine-containing acrylate as a hydrophobic monomer. Different ultraviolet (UV)-photocuring formulations are established based on different proportions of antibacterial agents and hydrophobic monomers. The surface morphology, double-bond transformation, thermal stability, mechanical properties, and antibacterial properties of coatings containing different proportions of additives are investigated. The results showed that the higher the QAC content in the coating, the better was the antibacterial effect. Moreover, the antibacterial-zone diameter of the coating reached 4.05 mm when 25% 1UV-F:9QAC was added. The double-bond conversion rate of all samples exceeded 80%. The mechanical properties deteriorated with the increase in the additives. The maximum water contact angle of the 1UV-F:9QAC coating was 91.1°. The 3UV-F:7QAC additive demonstrated the best comprehensive performance when the additive amount was 15%; it exhibited a bacteriostatic range of 1.3 mm against Staphylococcus aureus, a maximum tensile strength of 3.06 MPa, and an elongation at break of 44.0%. The coating exhibited a double-bond conversion rate exceeding 90%, and its thermal stability did not degrade significantly.