Simulation of Bioluminescence Tomography Based on Improved Half Threshold Algorithm

Fig. 1. Simulation experiment with single-source. (a) Digital mouse model containing source; (b) surface intensity distribution obtained by forward simulation

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Fig. 2. Cross-sectional views of reconstruction results on the XY plane at Z=9.2 mm center of the real light source obtained by three algorithms in single-source case. (a) PHTPA; (b) HTA ; (c) IRW-L1/2. Black circle represents real light source

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Fig. 3. Simulation experiments with double-light source. (a) Digital mouse model containing source; (b) surface intensity distribution when the density ratio is 1∶1; (c) surface intensity distribution when density ratio is 1∶2

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Fig. 4. Cross-sectional views of reconstruction results on the XY plane at Z=17.0 mm center of the real light source obtained by three algorithms in double-source case. (a)-(c) Reconstruction results of PHTPA, HTA, and IRW-L_1/2 when the density ratio is 1∶1; (d)-(f) reconstruction results of PHTPA, HTA, and IRW-L_1/2 when the density ratio is 1∶2. Black circle represents the real light source

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Fig. 5. Comparison of convergence rates of PHTPA(k=40) and HTA(k=50)

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Fig. 6. E_LE of PHTPA and HTA varying with sparse parameter k

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Table 1. Optical parameters of digital mouse organs at 670 nm wavelength
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Table 1. Optical parameters of digital mouse organs at 670 nm wavelength
Parameter Muscle Heart Stomach Liver Kidney Lung
${μ_{a}}_{}$ /mm^-1 0.10 0.21 0.01 0.126 0.066 0.22
${μ_{s}}_{}$ /mm^-1 1.20 2.00 1.74 0.563 2.250 2.30

Table 2. Reconstruction results in single-source case
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Table 2. Reconstruction results in single-source case
Method Reconstruction position center /mm ${E_{LE}}_{}$ /mm
PHTPA (11.15,6.14,9.66) 0.66
HTA (11.15,6.17,9.75) 0.73
IRW-L_1/2 (12.20,7.03,8.99) 1.21

Table 3. Reconstruction results in the double-source case when density ratio is 1∶1

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Table 3. Reconstruction results in the double-source case when density ratio is 1∶1

Method	Target	Reconstruction position center /mm	E_LE /mm
PHTPA	source 1	(11.60,7.73,18.51)	1.58
PHTPA	source 2	(12.24, 11.75,16.33)	0.75
HTA	source 1	(10.79,8.02,18.27)	1.74
HTA	source 2	(12.21,11.76,16.31)	0.75
IRW-L_1/2	source 1	(12.61,9.22,17.01)	1.37
IRW-L_1/2	source 2	(12.14,10.74 ,16.37)	1.40

Table 4. Reconstruction results in the double-source case with density ratio of 1∶2

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Table 4. Reconstruction results in the double-source case with density ratio of 1∶2

Method	Target	Reconstruction position center /mm	E_LE /mm
PHTPA	source 1	(11.60,7.73,18.52)	1.59
PHTPA	source 2	(12.24,11.75,16.33)	0.75
HTA	source 1	(10.76,8.03,18.26)	1.76
HTA	source 2	(12.21,11.76,16.31)	0.75
IRW-L_1/2	source 1	(12.57,9.09,16.86)	1.24
IRW-L_1/2	source 2	(12.14,10.06,16.15)	1.60

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Ziye Fang, Jingjing Yu. Simulation of Bioluminescence Tomography Based on Improved Half Threshold Algorithm[J]. Acta Optica Sinica, 2019, 39(10): 1017001

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Paper Information

Category: Medical Optics and Biotechnology

Received: Mar. 25, 2019

Accepted: Jun. 21, 2019

Published Online: Oct. 9, 2019

The Author Email: Yu Jingjing (yujj@snnu.edu.cn)

DOI:10.3788/AOS201939.1017001

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology

Table 1. Optical parameters of digital mouse organs at 670 nm wavelength

Table 1. Optical parameters of digital mouse organs at 670 nm wavelength

Table 2. Reconstruction results in single-source case

Table 2. Reconstruction results in single-source case

Table 3. Reconstruction results in the double-source case when density ratio is 1∶1

Table 3. Reconstruction results in the double-source case when density ratio is 1∶1

Table 4. Reconstruction results in the double-source case with density ratio of 1∶2

Table 4. Reconstruction results in the double-source case with density ratio of 1∶2