Advancements in implantable temperature sensors: Materials, mechanisms, and biological applications

Zhuofan Yang; Hongcheng Song; He Ding

doi:10.1088/1674-4926/24100003

Journal of Semiconductors, Volume. 46, Issue 1, 011609(2025)

Advancements in implantable temperature sensors: Materials, mechanisms, and biological applications

Zhuofan Yang¹, Hongcheng Song^2、*, and He Ding^1、**

¹Beijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optics and Photonics, Beijing Institute of Technology, Beijing 100081, China

²Department of Urology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China

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References(65)

[1] H C Koydemir, A Ozcan. Wearable and implantable sensors for biomedical applications. Annual Rev Anal Chem, 11, 127(2018).

[2] C Pang, C Lee, K Y Suh. Recent advances in flexible sensors for wearable and implantable devices. J Appl Polym Sci, 130, 1429(2013).

[3] E A Kiyatkin, P L Brown, R A Wise. Brain temperature fluctuation: A reflection of functional neural activation. Eur J Neurosci, 16, 164(2002).

[4] D Sim, M C Brothers, J M Slocik et al. Biomarkers and detection platforms for human health and performance monitoring: A review. Adv Sci, 9, 2104426(2022).

[5] M N Cramer, D Gagnon, O Laitano et al. Human temperature regulation under heat stress in health, disease, and injury. Physiol Rev, 102, 1907(2022).

[6] R Niedermann, E Wyss, S Annaheim et al. Prediction of human core body temperature using non-invasive measurement methods. Int J Biometeorol, 58, 7(2014).

[7] B B Lahiri, S Bagavathiappan, T Jayakumar et al. Medical applications of infrared thermography: A review. Infrared Phys Technol, 55, 221(2012).

[8] R Singh, M J Bathaei, E Istif et al. A review of bioresorbable implantable medical devices: Materials, fabrication, and implementation. Adv Healthcare Mater, 9, 2000790(2020).

[9] N Ashammakhi, A L Hernandez, B D Unluturk et al. Biodegradable implantable sensors: Materials design, fabrication, and applications. Adv Funct Mater, 31, 2104149(2021).

[10] D Lu, Y Yan, R Avila et al. Bioresorbable, wireless, passive sensors as temporary implants for monitoring regional body temperature. Adv Healthcare Mater, 9, 2000942(2020).

[11] M N Dakurah, C Koo, W Choi et al. Implantable bladder sensors: A methodological review. Int Neurourol J, 19, 133(2015).

[12] K Scholten, E Meng. Materials for microfabricated implantable devices: A review. Lab Chip, 15, 4256(2015).

[13] J H Koo, J K Song, S Yoo et al. Unconventional device and material approaches for monolithic biointegration of implantable sensors and wearable electronics. Adv Mater Technol, 5, 2000407(2020).

[14] T Yang, W L Deng, X Chu et al. Hierarchically microstructure-bioinspired flexible piezoresistive bioelectronics. ACS Nano, 15, 11555(2021).

[15] Y Qin, J L Mo, Y H Liu et al. Stretchable triboelectric self-powered sweat sensor fabricated from self-healing nanocellulose hydrogels. Adv Funct Mater, 32, 2201846(2022).

[16] M He, W W Du, Y M Feng et al. Flexible and stretchable triboelectric nanogenerator fabric for biomechanical energy harvesting and self-powered dual-mode human motion monitoring. Nano Energy, 86, 106058(2021).

[17] J Andreu-Perez, D R Leff, H M D Ip et al. From wearable sensors to smart implants−toward pervasive and personalized healthcare. IEEE Trans Biomed Eng, 62, 2750(2015).

[18] Y Q Liu, Q Yu, L Yang et al. Materials and biomedical applications of implantable electronic devices. Adv Mater Technol, 8, 2200853(2023).

[19] Z J Liu, B Tian, X Fan et al. A temperature sensor based on flexible substrate with ultra-high sensitivity for low temperature measurement. Sens Actuat A Phys, 315, 112341(2020).

[20] F Mailly, A Giani, R Bonnot et al. Anemometer with hot platinum thin film. Sens Actuat A Phys, 94, 32(2001).

[21] M S Ali, M S Ali, S Mallick et al. Dual parameter smart sensor for nitrogen and temperature sensing based on defect-engineered 1T-MoS2. Sci Rep, 14, 21469(2024).

[22] X Sun, Z C Li, W Y Fu et al. Li/Fe modified Zn0.3Ni0.7O NTC thermistors with adjustable resistivities and temperature sensitivity. J Mater Sci Mater Electron, 29, 343(2018).

[23] C Paladiya, A Kiani. Nano structured sensing surface: Significance in sensor fabrication. Sens Actuat B Chem, 268, 494(2018).

[24] S Chatterjee, M Saxena, D Padmanabhan et al. Futuristic medical implants using bioresorbable materials and devices. Biosens Bioelectron, 142, 111489(2019).

[25] J Q Wang, H Xie, T Chung et al. Neural probes with integrated temperature sensors for monitoring retina and brain implantation and stimulation. IEEE Trans Neural Syst Rehabil Eng, 25, 1663(2017).

[26] Y Moser, M A M Gijs. Miniaturized flexible temperature sensor. J Microelectromech Syst, 16, 1349(2007).

[27] S Y Xiao, L F Che, X X Li et al. A novel fabrication process of MEMS devices on polyimide flexible substrates. Microelectron Eng, 85, 452(2008).

[28] Q Li, L N Zhang, X M Tao et al. Review of flexible temperature sensing networks for wearable physiological monitoring. Adv Healthcare Mater, 6, 1601371(2017).

[29] Z C Shao, S Pala, Y Liang et al. Non-contact surface temperature sensing based on a single bimorph pMUTS array. 2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS), 861(2020).

[30] M D Han, L Chen, K Aras et al. Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery. Nat Biomed Eng, 4, 997(2020).

[31] D H Kim, N S Lu, R Ghaffari et al. Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy. Nat Mater, 10, 316(2011).

[32] S P Lee, L E Klinker, L Ptaszek et al. Catheter-based systems with integrated stretchable sensors and conductors in cardiac electrophysiology. Proc IEEE, 103, 682(2015).

[33] Y Kim, G A Parada, S D Liu et al. Ferromagnetic soft continuum robots. Sci Robot, 4, eaax7329(2019).

[34] T Yokota, P Zalar, M Kaltenbrunner et al. Ultraflexible organic photonic skin. Sci Adv, 2, e1501856(2016).

[35] D J Arndt-Jovin, M Robert-Nicoud, S J Kaufman et al. Fluorescence digital imaging microscopy in cell biology. Science, 230, 247(1985).

[36] M Cho, J K Han, J Suh et al. Fully bioresorbable hybrid opto-electronic neural implant system for simultaneous electrophysiological recording and optogenetic stimulation. Nat Commun, 15, 2000(2024).

[37] N Jiang, X H Chang, D W Hu et al. Flexible, transparent, and antibacterial ionogels toward highly sensitive strain and temperature sensors. Chem Eng J, 424, 130418(2021).

[38] Y Y Cui, M W Sun, C B Liu et al. All-inorganic ultrathin high-sensitivity transparent temperature sensor based on a Mn–Co–Ni–O nanofilm. Microsyst Nanoeng, 10, 70(2024).

[39] K J Yu, Z Yan, M D Han et al. Inorganic semiconducting materials for flexible and stretchable electronics. NPJ Flex Electron, 1, 4(2017).

[40] G Liu, Z Y Lv, S Batool et al. Biocompatible material-based flexible biosensors: From materials design to wearable/implantable devices and integrated sensing systems. Small, 19, 2207879(2023).

[41] K Kwon, J U Kim, S M Won et al. A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature. Nat Biomed Eng, 7, 1215(2023).

[42] N Milani-Nejad, P M L Janssen. Small and large animal models in cardiac contraction research: Advantages and disadvantages. Pharmacol Ther, 141, 235(2014).

[43] S Coffey, R Roberts-Thomson, A Brown et al. Global epidemiology of valvular heart disease. Nat Rev Cardiol, 18, 12(2021).

[44] J Charthad, M J Weber, T C Chang et al. A mm-sized implantable medical device (IMD) with ultrasonic power transfer and a hybrid bi-directional data link. IEEE J Solid State Circuits, 50, 1741(2015).

[45] S Lee, A J Cortese, A P Gandhi et al. A 250 μm × 57 μm microscale opto-electronically transduced electrodes (MOTEs) for neural recording. IEEE Trans Biomed Circuits Syst, 12, 1256(2018).

[46] A J Cortese, C L Smart, T Y Wang et al. Microscopic sensors using optical wireless integrated circuits. Proc Natl Acad Sci USA, 117, 9173(2020).

[47] M Xu, X M Zou, Q Q Su et al. Ratiometric nanothermometer in vivo based on triplet sensitized upconversion. Nat Commun, 9, 2698(2018).

[48] G Y Chen, H L Qiu, P N Prasad et al. Upconversion nanoparticles: Design, nanochemistry, and applications in theranostics. Chem Rev, 114, 5161(2014).

[49] M V Chernov, S V Gushchin, A M Kuzmin et al. Infrared to visible up-conversion luminescence of SrF2: Ho particles upon excitation of the 5I7 level of Ho3+ ions. J Lumin, 261, 119942(2023).

[50] G H Lee, H Moon, H Kim et al. Multifunctional materials for implantable and wearable photonic healthcare devices. Nat Rev Mater, 5, 149(2020).

[51] H Ding, G Q Lv, X Cai et al. An Optoelectronic thermometer based on microscale infrared-to-visible conversion devices. Light Sci Appl, 11, 130(2022).

[52] J Shin, Z H Liu, W B Bai et al. Bioresorbable optical sensor systems for monitoring of intracranial pressure and temperature. Sci Adv, 5, eaaw1899(2019).

[53] C X Zhu, H C Wu, G Nyikayaramba et al. Intrinsically stretchable temperature sensor based on organic thin-film transistors. IEEE Electron Device Lett, 40, 1630(2019).

[54] T Someya, Z N Bao, G G Malliaras. The rise of plastic bioelectronics. Nature, 540, 379(2016).

[55] T Yokota, Y Inoue, Y Terakawa et al. Ultraflexible, large-area, physiological temperature sensors for multipoint measurements. Proc Natl Acad Sci USA, 112, 14533(2015).

[56] Y Chen, A Pépin. Nanofabrication: Conventional and nonconventional methods. Electrophoresis, 22, 187(2001).

[57] M Mittal, S Sardar, A Jana. Nanofabrication techniques for semiconductor chemical sensors. Handbook of Nanomaterials for Sensing Applications. Amsterdam: Elsevier, 119(2021).

[58] S Ahmad. Organic semiconductors for device applications: Current trends and future prospects. J Polym Eng, 34, 279(2014).

[59] M Eslamian. Inorganic and organic solution-processed thin film devices. Nanomicro Lett, 9, 3(2017).

[60] A Vishwakarma, N S Bhise, M B Evangelista et al. Engineering immunomodulatory biomaterials to tune the inflammatory response. Trends Biotechnol, 34, 470(2016).

[61] D H Zhang, Q Chen, C Shi et al. Dealing with the foreign-body response to implanted biomaterials: Strategies and applications of new materials. Adv Funct Mater, 31, 2007226(2021).

[62] Y Ding, R C Ma, G H Liu et al. Fabrication of a new hyaluronic acid/gelatin nanocomposite hydrogel coating on titanium-based implants for treating biofilm infection and excessive inflammatory response. ACS Appl Mater Interfaces, 15, 13783(2023).

[63] T V Basova, E S Vikulova, S I Dorovskikh et al. The use of noble metal coatings and nanoparticles for the modification of medical implant materials. Mater Des, 204, 109672(2021).

[64] A Kros, M Gerritsen, V S I Sprakel et al. Silica-based hybrid materials as biocompatible coatings for glucose sensors. Sens Actuat B Chem, 81, 68(2001).

[65] K Chen, J Y Ren, C Y Chen et al. Safety and effectiveness evaluation of flexible electronic materials for next generation wearable and implantable medical devices. Nano Today, 35, 100939(2020).

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Zhuofan Yang, Hongcheng Song, He Ding. Advancements in implantable temperature sensors: Materials, mechanisms, and biological applications[J]. Journal of Semiconductors, 2025, 46(1): 011609

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Paper Information

Category: Research Articles

Received: Oct. 4, 2024

Accepted: --

Published Online: Mar. 6, 2025

The Author Email: Song Hongcheng (HCSong), Ding He (HDing)

DOI:10.1088/1674-4926/24100003

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