Chinese Journal of Lasers, Volume. 45, Issue 2, 207018(2018)

Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing

Li Conghui1,2, Cao Ruofan1,2、*, Xu Xiayu1,2, Li Fei2,3, Zhang Zhenxi1, and Xu Feng1,2
Author Affiliations
  • 1[in Chinese]
  • 2[in Chinese]
  • 3[in Chinese]
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    Figures & Tables(6)
    Schematic of lensless imaging technology[27-29]. (a) Shadow lensless microscopic imaging; (b) fluorescence lenslessmicroscopic imaging; (c) transmission digital holography lensless microscopic imaging; (d) reflective digital holography lensless microscopic imaging
    Principle of super-resolution algorithm
    3D structures of acini analyzed by lensless digital holography microscopic imaging technology. (a) Schematic of the device for the detection of acinar morphology; (b) normal acini; (c) acini lack of polarity
    Application of lensless imaging technology for (a) cardiotoxicity detection; (b) sperm shape analysis[57]
    Application of lensless imaging technology for bacteria detection. (a) Bacteria detection device of lensless digital coaxial holography microscopy based on wetting thin film[59]; (b) whole cell biosensor biochip based on biological luminescence[63]
    • Table 1. Comparison of three types of lensless imaging technology

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      Table 1. Comparison of three types of lensless imaging technology

      SystemLight sourceStructure requirementReconstructionRange of field
      Shadow imagingMonochrome orwhite light LEDSample must beclose to CCDSuper-resolution[47-50]Semitransparent oropaque samples
      Fluorescence imagingMonochromeLED or laserFiltersSuper-resolution[47-50],compressive sampling[33]Fluorescent samples
      Holographic imagingLaserPinholePhase retrieval[40-41],twin image elimination[42],angular spectrum[43]Transparent orsemitransparent samples
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    Li Conghui, Cao Ruofan, Xu Xiayu, Li Fei, Zhang Zhenxi, Xu Feng. Application Progress of Lensless Microscopy Imaging Technology for Point-of-Care Testing[J]. Chinese Journal of Lasers, 2018, 45(2): 207018

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    Paper Information

    Special Issue:

    Received: Mar. 30, 2017

    Accepted: --

    Published Online: Feb. 28, 2018

    The Author Email: Ruofan Cao (caoruofan66@163.com)

    DOI:10.3788/CJL201845.0207018

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